Advertisement

Uptake and efflux of serotonin from platelets of autistic and nonautistic children

  • Arthur Yuwiler
  • Edward Ritvo
  • Edward Geller
  • Ronald Glousman
  • Gary Schneiderman
  • Diane Matsuno
Articles

Abstract

This study examined, in vitro, the uptake and efflux of serotonin by platelets from autistic children, nonautistic hospitalized comparison cases, and normal children. The autistic patients were carefully selected according to previously established diagnostic criteria. The hospitalized comparison children were utilized to assess possible environmental and dietary influences upon the results. Uptake methods were similar to those used by previous investigators. Two efflux procedures were utilized to explore the possibility that methodological factors accounted for previously reported differences between autistic and comparison groups. The results failed to indicate statistically significant differences in uptake or efflux between the autistic and the hospitalized comparison groups or the normals. Methodologic considerations which could possibly account for the failure to confirm previous findings are discussed in detail.

Keywords

Serotonin Comparison Group Normal Child Autistic Child Methodologic Consideration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bender, L. Childhood schizophrenia: A review.International Journal of Psychiatry, 1968,5, 211.PubMedGoogle Scholar
  2. Boullin, D. J., Coleman, M., & O'Brien, R. A. Abnormalities in platelet 5-hydroxytryptamine efflux in patients with infantile autism.Nature, 1970,226, 371–372.PubMedGoogle Scholar
  3. Boullin, D. J., Coleman, M., O'Brien, R. A., & Rimland, B. Laboratory predictions of infantile autism based on 5-hydroxytryptamine efflux from blood platelets and their correlation with the Rimland E2 score.Journal of Autism and Childhood Schizophrenia, 1971,1, 63–71.PubMedGoogle Scholar
  4. Coleman, M. (Ed.).Serotonin in Down's Syndrome. New York: American Elsevier, 1973. Chap. 9.Google Scholar
  5. Kanner, L. Autistic disturbances of affective contact.Nervous Child, 1943,2, 217–250.Google Scholar
  6. Kattlove, H. E., & Alexander, B. The effect of cold on platelets: Cold-induced platelet aggregation.Blood, 1971,38, 39–48.PubMedGoogle Scholar
  7. Lucas, A. R., Warner, K., & Gottlieb, J. S. Biological studies in childhood schizophrenia.Biological Psychiatry, 1971,3, 123–128.PubMedGoogle Scholar
  8. Ornitz, E. M. Childhood autism: A review of the clinical and experimental literature (medical progress).California Medicine, 1973,118, 21–47.PubMedGoogle Scholar
  9. Ornitz, E. M., & Ritvo, E. R. Perceptual inconstancy in early infantile autism.Archives of General Psychiatry, 1968,18, 76–98.PubMedGoogle Scholar
  10. Pletscher, A. Metabolism, transfer and storage of 5-hydroxytryptamine in blood platelets.British Journal of Pharmacology and Chemotherapy, 1968,32, 1–16.Google Scholar
  11. Rabinovitch, R. D., Lucas, A. R., Ingram, W.,& Shaw, C. R.Childhood schizophrenia: Evolution to adulthood. Presented at American Orthopsychiatric Association Annual Meeting, New York, 1965.Google Scholar
  12. Rimland, B. On the objective diagnosis of infantile autism.Acta Paedopsychiatrica, 1968,35, 1946–1961.Google Scholar
  13. Ritvo, E. R., Yuwiler, A., Geller, E., Ornitz, E. M., Saeger, K., & Plotkin, S. Increased blood serotonin and platelets in early infantile autism.Archives of General Psychiatry, 1970,23, 566–572.PubMedGoogle Scholar
  14. Siva Sankar, D. V., Cates, N., Broer, H., & Sankar, D. B. Biochemical parameters of childhood schizophrenia (autism) and growth. In J. Wortis (Ed.),Recent Advances in Biological Psychiatry (Vol. 5). New York: Plenum, 1963, pp. 76–83.Google Scholar
  15. Umbreit, W. W., Burris, R. H., & Stauffer, T. D.Mannometric techniques. Minneapolis: Burgess, 1949.Google Scholar
  16. Yuwiler, A., Plotkin, S., Geller, E., & Ritvo, E. Rapid accurate procedure for the determination of serotonin in whole human blood.Biochemical Medicine, 1970,3, 426–436.PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • Arthur Yuwiler
    • 1
    • 2
  • Edward Ritvo
    • 1
    • 2
  • Edward Geller
    • 1
    • 2
  • Ronald Glousman
    • 1
    • 2
  • Gary Schneiderman
    • 1
    • 2
  • Diane Matsuno
    • 1
    • 2
  1. 1.Neurobiochemistry Laboratory-T-85Veterans Administration HospitalLos Angeles
  2. 2.Division of Mental Retardation and Child PsychiatryUniversity of California, Los Angeles School of MedicineUSA

Personalised recommendations