Response to stimulant drug treatment in hyperactive children: Prediction from EEG and neurological findings
- 126 Downloads
A study of neurological examinations, EEG findings, and behavioral responses to methylphenidate treatment in 57 hyperactive boys, 5 to 10 years of age, is reported and discussed. The results indicated that subjects with minor neurological abnormalities in 4 or more categories responded with significantly more improvement (p<.01) to methylphenidate treatment than subjects without abnormalities. Subjects with abnormal EEGs had significantly more improvement (p<.001) than those with normal EEGs. A significant correlation was found between the degree of evidence of brain dysfunction (obtained from EEG and neurological examinations) and the probability of response to methylphenidate treatment. It is suggested that both the neurological and the EEG examinations play a significant role in the assessment of hyperactive children.
KeywordsSignificant Role Drug Treatment Behavioral Response Neurological Examination Methylphenidate
Unable to display preview. Download preview PDF.
- Clements, S. D.Minimal brain dysfunction in children. NINDB Monograph #3, U.S. Public Health Service, Washington, D.C., 1966.Google Scholar
- Hoffman, H.Der Struwelpeter: Oder Lustige Geschichten und Drollige Bilder. Leipzig: Insel Vorlag, 1844.Google Scholar
- Hughes, J. R. Electroencephalography and learning disability. In H. R. Mykelbust (Ed.),Progress in learning disabilities. Vol. II. New York: Grune & Stratton, 1971.Google Scholar
- Millichap, J. G. Drugs in the management of minimal brain dysfunction.Annals of New York Academy of Sciences, 1973,205, 321–334.Google Scholar
- Paine, R. S. Syndromes of minimal cerebral damage.Pediatric Clinic of North America, 1968,15, 779–799.Google Scholar
- Paine, R. S., & Oppe, T. E. Neurological examination of children.Clinics in developmental medicine No. 20/21. London: Spastics International Medical Publications & Wm. Heinemann, 1966.Google Scholar
- Rutter, M., Graham, P., & Yule, W. A neuropsychiatric study in childhood.Clinics in Developmental Medicine No. 35/36. London: Spastics International Medical Publications & Wm. Heinemann, 1970.Google Scholar
- Satterfield, J. H., Atoian, G. E., Brashears, G. C., Burleigh, A. C., & Dawson, M. E. Electrodermal studies of minimal brain dysfunction in children.Exerpta Medica, 1973, in press.Google Scholar
- Satterfield, J. H., Lesser, L. I., Saul, R. E., & Cantwell, D. P. EEG aspects in the diagnosis and treatment of minimal brain dysfunction.Annals. of New York Academy of Sciences, 1973,205, 274–282.Google Scholar