Digestive Diseases and Sciences

, Volume 34, Issue 8, pp 1185–1192

Cyclic motility in canine colon: Responses to feeding and perfusion

  • Bernard Flourie
  • Sidney Phillips
  • Harry RichterIII
  • Fernando Azpiroz
Original Articles


To further characterize colonic motility in the dog and to examine the effects of intraluminal contents, motor activity in conscious animals was recorded by perfused intraluminal catheters. Animals were studied first with the bowel intact and, later, the colon was fashioned into an isolated loop. In the fasting state, cycles of motility recurred approximately each 30 min. These consisted of sequences of phasic contractions (bursts) that migrated variable distances in either direction; stationary bursts were also recorded. The fasting patterns recorded from intact bowel and isolated loops were not different. Feeding increased colonic motility, and the mean periodicity of cyclic bursts was reduced significantly to approximately 20 min. Moreover, differences were observed between intact bowel and isolated loops in the postprandial period. Diversion of chyme from the colon significantly reduced the motor response to food, but only in the late (2– 4 hr) postprandial period, when the less frequent, fasting cycle returned to the loops. Perfusion of isolated loops with chyme or saline reestablished the postprandial pattern seen in intact bowel. The results suggest that the volume, but not the composition, of luminal contents modify postprandial motility in the canine colon. Additional experiments confirmed that, in particular, volatile fatty acids were probably not important determinants of colonic motility in the dog.

Key words

canine colon cyclic motility response to food colonic transit 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Templeton RD, Lawson H: Studies in the motor activity of the large intestine. I. Normal motility in the dog recorded by the tandem balloon method. Am J Physiol 96:667–676, 1931Google Scholar
  2. 2.
    Welch PB, Plant OH: A graphic study of the muscular activity of the colon, with special reference to its response to feeding. Am J Med Sci 172:261–268, 1926Google Scholar
  3. 3.
    Schuurkes JAJ, Tukker JJ: The interdigestive colonic motor complex of the dog. Arch Int Pharmacodyn Ther 247:329–334, 1980PubMedGoogle Scholar
  4. 4.
    Bueno L, Fioramonti J, Ruckebusch M: Comparative effects of morphine and nalorphine on colonic motility in the conscious dog. Eur J Pharmacol 75:239–245, 1981PubMedGoogle Scholar
  5. 5.
    Fioramonti J, Bueno L: Diurnal changes in colonic motor profile in conscious dogs. Dig Dis Sci 28:257–264, 1983PubMedGoogle Scholar
  6. 6.
    Fioramonti J, Garcia-Villar R, Bueno L, Ruckebusch Y: Colonic myoelectrical activity and propulsion in the dog. Dig Dis Sci 25:641–646, 1980PubMedGoogle Scholar
  7. 7.
    Sarna SK, Condon R, Cowles V: Colonic migrating and nonmigrating motor complexes in dogs. Am J Physiol 246:G355-G360, 1984PubMedGoogle Scholar
  8. 8.
    Sarna SK, Lang JM: Effect of a meal on colonic motor complexes: Gastrocolonic response. Gastroenterology 88: 1571, 1985 (abstract)Google Scholar
  9. 9.
    Sarna SK: Myoelectric correlates of colonic motor complexes and contractile activity. Am J Physiol 250:G213-G220, 1986PubMedGoogle Scholar
  10. 10.
    Burrows CF, Merritt AM: Influence of α-cellulose on myoelectric activity of proximal canine colon. Am J Physiol 245:G301-G306, 1983PubMedGoogle Scholar
  11. 11.
    Fioramonti J, Bueno L: Motor activity in the large intestine of the pig related to dietary fibre and retention time. Br J Nutr 43:155–162, 1980PubMedGoogle Scholar
  12. 12.
    Cherbut G, Ruckebusch Y: Modifications de l'electromyogramme du cÔlon lieés a l'ingestion de particules non digestibles chez le chien. Gastroenterol Clin Biol 8:955–959, 1984PubMedGoogle Scholar
  13. 13.
    Tansy MF, Kendall FM: Experimental and clinical aspects of gastrocolic reflexes. Dig Dis Sci 18:521–531, 1973Google Scholar
  14. 14.
    Collin J, Kelly KA, Phillips SF: Enhancement of absorption from the intact and transected canine small intestine by electrical pacing. Gastroenterology 76:1422–1428, 1979PubMedGoogle Scholar
  15. 15.
    Kamath PS, Hoepfner MT, Phillips SF: Short chain fatty acids stimulate motility of the canine ileum. Am J Physiol 253:G427-G433, 1987PubMedGoogle Scholar
  16. 16.
    Quigley EMM, Phillips SF, Dent J, Taylor BM: Myoelectric activity and intraluminal pressure of the canine ileocolonic sphincter. Gastroenterology 85:1054–1062, 1983PubMedGoogle Scholar
  17. 17.
    Atanassova E, Noeva A, Gachilova S: Relationship between the spike activities of the small and large intestines. Dig Dis Sci 30:757, 1985 (abstract)Google Scholar
  18. 18.
    Christensen J, Anuras S, Hansen RL: Migrating spike bursts and electrical slow waves in the cat colon: Effect of sectioning. Gastroenterology 66:240–247, 1974PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Bernard Flourie
    • 1
  • Sidney Phillips
    • 1
  • Harry RichterIII
    • 1
  • Fernando Azpiroz
    • 1
  1. 1.Gastroenterology UnitMayo ClinicRochester

Personalised recommendations