Digestive Diseases and Sciences

, Volume 35, Issue 1, pp 121–132

Postoperative ileus

  • Edward H. Livingston
  • Edward P. PassaroJR
Review Article

Key words

paralytic ileus gastrointestinal motility surgical complications anesthesia 

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References

  1. 1.
    Wangensteen OH: The early diagnosis of acute intestinal obstruction with comments on pathology and treatment: With a report on successful decompression of three cases of mechanical small bowel obstruction by nasal catheter siphonage. West J Surg Obstet Gynecol 40:1–17, 1932Google Scholar
  2. 2.
    Moss G, Regal ME, Lichtig LK: Reducing postoperative pain, narcotics and length of hospitalization. Surgery 90:206–210, 1986Google Scholar
  3. 3.
    Neely J, Catchpole B: Ileus: The restoration of alimentary tract motility by pharmacological means. Br J Surg 58:21–28, 1971PubMedGoogle Scholar
  4. 4.
    Pal J: Uber den einfluss des bauchschnittes auf die darmbewegung. Zentralbl Physiol 4:338, 1890Google Scholar
  5. 5.
    Bayliss WM, Starling EH: The movements and innervations of the small intestine. J Physiol (London) 24:99–143, 1899Google Scholar
  6. 6.
    Cannon WB, Murphy FT: The movement of the stomach and intestine in some surgical conditions. Ann Surg 43:512–536, 1906Google Scholar
  7. 7.
    Cannon WB, Murphy FT: Physiologic observations on experimentally produced ileus. JAMA 49:840–843, 1907Google Scholar
  8. 8.
    Elliot TR, Barclay-Smith E: Antiperistalsis and other muscular activities in the colon. J Physiol (London) 31:272–304, 1904Google Scholar
  9. 9.
    Olivecrona H: An experimental study of postoperative, so called paralytic ileus. Acta Chir Scand 61:485–534, 1927Google Scholar
  10. 10.
    Oshsner A, Gage IM, Cutting RA: Treatment of ileus by splanchnic anesthesia: Preliminary report of experimental study. JAMA 90:1847–1853, 1928Google Scholar
  11. 11.
    Mackay ME: The action of histamine on the motility of different parts of the intestinal tract. Am J Physiol 1030:527–536, 1930Google Scholar
  12. 12.
    McSwiney BA: Innervation of the stomach. Physiol Rev 11:478–514, 1931Google Scholar
  13. 13.
    Garry RC: The movements of the large intestine. Physiol Rev 14:103–132, 1934Google Scholar
  14. 14.
    Sealy WB, Witcher SL: Sympathetic denervation upon peristalsis of the cat small intestine in situ. Proc Soc Exp Biol Med 34:806–807, 1936Google Scholar
  15. 15.
    Ratkoczy N: Neue grundsteine zur fuhktionellen röntgendiagnostik des magens. Fortschr Röntgenstr 43:343–353, 1936Google Scholar
  16. 16.
    Morin G, Kofman T, Dugal PJ: Des relations du transit gastrique et de la sympathectomie abdominale totale chez le chien. CR Soc Biol 124:772–776, 1937Google Scholar
  17. 17.
    Bisgard JD, Johnson EK: The influence of certain drugs and anesthetics upon gastro-intestinal tone and motility. Ann Surg 110:802–822, 1939Google Scholar
  18. 18.
    Wakim KG, Mann FC: The effects of some intra-abdominal procedures on intestinal activity. Gastroenterology 1:513–517, 1943Google Scholar
  19. 19.
    Douglas DM, Mann FC: The effect of peritoneal irritation on the activity of the intestine. Br Med J 1:227–231, 1941Google Scholar
  20. 20.
    Wells C, Rawlinson K, Tinckler L, Jones H, Saunders J: Ileus and postoperative intestinal motility. Lancet 2:136–137, 1961PubMedGoogle Scholar
  21. 21.
    Arai K: Experimentelle Untersuchungen über die Meagen-Darmbewegungen bei akuter Peritonitis. Arch Exp Path Pharmakol 94:149–189, 1922Google Scholar
  22. 22.
    King CE: Studies on intestinal inhibitory reflexes. Am J Physiol 70:183–193, 1924Google Scholar
  23. 23.
    Hotz G: Beitrage zur Pathologie der Darmbewegunen. Mitt Grenzgeb Med Chir 20:257–318, 1909Google Scholar
  24. 24.
    Youmans WB, Waisman RC: Effect of beta-methylcholineurethane on normal and on reflexly inhibited intestine. Proc Soc Exp Biol Med 39:135–140, 1938Google Scholar
  25. 25.
    Youmans WB: Neural regulation of gastric and intestinal motility. Am J Med 13:209–226, 1952PubMedGoogle Scholar
  26. 26.
    Wagner GA: Zur Behandlung des Ileus mit lumbal Anästhesie. Arch Gynaekol 117:336, 1922Google Scholar
  27. 27.
    Markowitz J, Campbell WR: The relief of experimental ileus with spinal anesthesia. Am J Physiol 81:101–106, 1927Google Scholar
  28. 28.
    Garry RC: The nervous control of the caudal region of the large bowel in the cat. J Physiol (London) 77:422–431, 1933Google Scholar
  29. 29.
    Burstein CL: Effect of spinal anesthesia on intestinal activity. Proc Soc Exp Biol Med 42:291–293, 1939Google Scholar
  30. 30.
    Lapointe MA: La rachianesthésie dans l'iléus aigu. Bull Mem Soc Natl Chir 53:474–478, 1927Google Scholar
  31. 31.
    Bisgard JD, Matson GM, Hirschmann J: Adynamic ileus and thermal influences on gastric and intestinal motor activity. JAMA 118:447–451, 1942Google Scholar
  32. 32.
    Wallin G, Cassuto J, Hogstrom S, Rimback G, Faxen A: Failure of epidural anesthesia to prevent postoperative paralytic ileus: Anesthesiology 65:292–297, 1986PubMedGoogle Scholar
  33. 33.
    Wagner GA: Behandlung der paralytischen Ileus. Berl Klin Wochenschr 56:1221–1222, 1919Google Scholar
  34. 34.
    Ochsner A, Gage IM, Cutting RA: The value of drugs in the relief of ileus. Arch Surg Chicago 21:924–928, 1930Google Scholar
  35. 35.
    Catchpole BN: Ileus: Use of sympathetic blocking agents in its treatment. Surgery 66:811–820, 1969PubMedGoogle Scholar
  36. 36.
    Baker, LW, Dudley HA: Auscultation of the abdomen in surgical patients. Lancet 2:517–519, 1961PubMedGoogle Scholar
  37. 37.
    Farrar JJ, Ingelfinger FJ: Gastrointestinal motility as revealed by study of abdominal sounds. Gastroenterology 29:789–799, 1955PubMedGoogle Scholar
  38. 38.
    Dahlgren S, Selking O: Postoperative motility of the small intestine. Upsala J Med Sci 77:202, 1972PubMedGoogle Scholar
  39. 39.
    Tinckler LF: Surgery and intestinal motility. Br J Surg 52:140–150, 1965PubMedGoogle Scholar
  40. 40.
    Carmichael MJ, Weisbrodt NW, Copeland EM: Effect of abdominal surgery on myoelectric activity in the dog. Am J Surg 133:34–38, 1977PubMedGoogle Scholar
  41. 41.
    Sabiston DC: Textbook of Surgery: The Biological Basis of Modern Surgical Practice. Philadelphia, WB Saunders, 1986Google Scholar
  42. 42.
    McPhail JL, Hardy JD, Conn JH, Shor J, Robinson S: Studies of postoperative ileus: intestinal motility as reflected in the propulsion of radiopaque materials. Surg Forum 2:471–473, 1958Google Scholar
  43. 43.
    Rothnie NG, Harper RA, Catchpole BN: Early postoperative gastrointestinal activity. Lancet 2:64–67, 1963PubMedGoogle Scholar
  44. 44.
    Harrower LW: Postoperative ileus. Am J Surg 116:369–374, 1968PubMedGoogle Scholar
  45. 45.
    Devine JA: A concept of paralytic ileus. Br J Surg 7:159–179, 1946Google Scholar
  46. 46.
    Graber JN, Schulte WJ, Condon RE: The duration of postoperative ileus related to the extent and site of operative dissection. Surg Forum 31:141–144, 1980Google Scholar
  47. 47.
    Rimback G, Cassuto J, Faxen A, Hogstrom S, Wallin G: Effect of intra-abdominal bupivicaine instillation on postoperative colonic motility. Gut 27:170–175, 1986PubMedGoogle Scholar
  48. 48.
    Condon RE, Cowles VE, Schulte WJ, Frantzides CT, Mahoney JL, Sarna SK: Resolution of postoperative ileus in humans. Ann Surg 203:574–581, 1986PubMedGoogle Scholar
  49. 49.
    Kewenter J, Kock NG: Studies on intestinal motility the first few days after partial gastrectomy and after cholecystectomy. Acta Chir Scand 125:248–253, 1963PubMedGoogle Scholar
  50. 50.
    Noer T: Roentgenological transit time through the small intestine in the immediate postoperative period. Acta Chir Scand 124:557–580, 1968Google Scholar
  51. 51.
    Smith J, Kelly KA, Weinshillboum RM: Pathophysiology of postoperative ileus. Arch Surg 112:203–209, 1977PubMedGoogle Scholar
  52. 52.
    Bernstein A, Wright AC, Spencer D: Pheochromocytoma as a cause of gastrointestinal distension. Postgrad Med J 43:180–183, 1967PubMedGoogle Scholar
  53. 53.
    Landman MD, Longmire WP Jr: Neural and hormonal influences of peritonitis on paralytic ileus. Am Surg 33:756–762, 1967PubMedGoogle Scholar
  54. 54.
    Dubois A, Henry DP, Kopin IJ: Plasma catecholamines and postoperative gastric emptying and small bowel propulsion in the rat. Gastroenterology 68:466–469, 1975PubMedGoogle Scholar
  55. 55.
    Weiskopf RB, Reid IA, Fisher DM, Holmes MA, Rosen JI, Keil LC: Effects of fentanyl on vasopressin human subjects. J Pharmacol Exp Ther 242:970–973, 1987PubMedGoogle Scholar
  56. 56.
    Cochrane JPS, Forsling ML, Gow NM, LeQuesne LP: Arginine vasopressin release following surgical operations. Br J Surg 68:209–213, 1981PubMedGoogle Scholar
  57. 57.
    Mitchell A, Collin J: Vasopressin effect on the small intestine: A possible factor in paralytic ileus? Br J Surg 72:462–465, 1985PubMedGoogle Scholar
  58. 58.
    Sarna SK: Small and large bowel motility and postoperative disorders.In Surgical Care II. RE Condon, J DeCosse (eds). Philadelphia, Lea & Febiger, 1985Google Scholar
  59. 59.
    Sato, Y, Terui N: Changes in duodenal motility produced by noxious mechanical stimulation of the skin in rats. Neurosci Lett 2:189–193, 1976Google Scholar
  60. 60.
    Kewenter J: The vagal control of duodenal and ileal motility and blood flow. Acta Physiol Scand 63:1–68, 1965Google Scholar
  61. 61.
    Furness JB, Costa M: Adynamic ileus, its pathogenesis and treatment. Med Biol 52:82–89, 1974PubMedGoogle Scholar
  62. 62.
    Furness JB, Costa M: The adrenergic innervation of the gastrointestinal tract. Ergeb Physiol 69:1–51, 1973Google Scholar
  63. 63.
    Kuntz A, Sacomanno G: Reflex inhibition of intestinal motility through decentralized prevertebral ganglia. J Neurophysiol 7:163–170, 1944Google Scholar
  64. 64.
    Youmans WB: Nervous and Neurohumerol Regulation of Intestinal Motility. New York, Interscience Publishers, 1949Google Scholar
  65. 65.
    Youmans WB: Innervation of the gastrointestinal tract.In Handbook of Physiology, Vol 4. CF Code (ed). Washington, DC, American Physiology Society, 1968Google Scholar
  66. 66.
    Fasano M, Waldvogel HH, Muller CA: Prevention of paralytic ileus after colonic surgery by continuous peridural sympathetic block. Preliminary report. Hel Chirurg Acta 46:245–248, 1979Google Scholar
  67. 67.
    Dubois A, Kopin IJ, Pettigrew KD, Jacobowitz MD: Chemical and histochemical studies of postoperative sympathetic activity in the digestive tract of the rat. Gastroenterology 66:403–407, 1974PubMedGoogle Scholar
  68. 68.
    Nilsson F, Jung B: Gastric evacuation and small propulsion after laparotomy. Acta Chir Scand 139:724–730, 1973PubMedGoogle Scholar
  69. 69.
    Dubois A, Weise VK, Kopin IJ: Postoperative ileus in the rat: Physiology, etiology and treatment. Ann Surg 178:781–786, 1973PubMedGoogle Scholar
  70. 70.
    Dubois A, Watanabe AM, Kopin IJ: Postoperative gastric ileus. Am J Dig Dis 18:39–42, 1973PubMedGoogle Scholar
  71. 71.
    Holzer, P, Lippe IT, Holzer Petsche U: Inhibition of gastrointestinal transit due to surgical trauma or peritoneal irritation is reduced in capsaicin-treated rats. Gastroenterology 91:360–363, 1986PubMedGoogle Scholar
  72. 72.
    Glise H, Lindahl BO, Abrahamson H: Reflex adrenergic inhibition of gastric motility by nociceptive intestinal stimulation and peritoneal irritation in the cat. Scand J Gastroenterol 15:673–681, 1981Google Scholar
  73. 73.
    Maggi CA, Manzini S, Meli A: Contribution of neurogenic and myogenic factors in the response of rat proximal colon to distension. Am J Physiol 252:G447-G457, 1987PubMedGoogle Scholar
  74. 74.
    Gillis RA, Souza JD, Hicks KA, Mangel AW, Pagani FD, Hamilton BL, Garvey TQ, Pace DG, Browne RK, Norman WP: Inhibitory control of proximal colonic motility by the sympathetic system. Am J Physiol 253:G531-G539, 1987PubMedGoogle Scholar
  75. 75.
    Fleischman RW, McCracken D, Forbes W: Adynamic ileus in the rat induced by chloral hydrate. Lab Anim Sci 27:238–243, 1977PubMedGoogle Scholar
  76. 76.
    Wright JW, Healy TEJ, Balfour TW, Hardcastle JD: Effects of inhalational anesthetic agents on the electrical and mechanical activity of the rat duodenum. Br J Anesth 54:1223–1229, 1982Google Scholar
  77. 77.
    Emmerson GA: Intestinal motility in rats anesthetized with ether. Am J Dig Dis 4:255–256, 1937Google Scholar
  78. 78.
    Reynell PC, Spray GH: The effect of ether and pentobarbitone sodium on gastrointestinal function in the intact rat. Br J Pharmacol 12:104–106, 1957PubMedGoogle Scholar
  79. 79.
    Ohrn PG, Johansson H, Nilsson F: Influence of ether anesthesia and oro-gastric intubation on gastric evacuation and small bowel propulsion after laparotomy. Acta Chir Scand (Suppl) 461:5–16, 1976Google Scholar
  80. 80.
    Marshall FN, Pittinger CB, Long JP: Effects of halothane on gastrointestinal motility. Anesthesiology 22:363–366, 1961PubMedGoogle Scholar
  81. 81.
    Konturek SJ, Thor P, Krol R, Dembinski A, Schall: Influence of methionine-enkephalin and morphine on electrical activity of the small bowel. Am J Physiol 238:G384-G389, 1980PubMedGoogle Scholar
  82. 82.
    Terawaki Y, Takayanagi I, Takagi K: Effects of 5-hydroxytryptamine and morphine on the stomach motility in situ. Jpn J Pharmacol 26:7–12, 1976Google Scholar
  83. 83.
    Weisbrodt NW, Sussman SE, Stewart JJ, Burks TF: Effect of morphine sulfate on intestinal transit and myoelectric activity of the small intestine of the rat. J Pharmacol Exp Ther 214:333–338, 1980PubMedGoogle Scholar
  84. 84.
    Howd RA, Adamovics J, Palekar A: Naloxone and intestinal motility. Experientia 34:1310–1311, 1978PubMedGoogle Scholar
  85. 85.
    Frey S: Experimenteller Beitrag zur Prophylaxe und Therapie der Darmlahmung. Arch Klin Chir 142:445–457, 1926Google Scholar
  86. 86.
    Zimmerman LM, Frank R, Necheles H: Effect of acetylcholine and of physostigmine on gastrointestinal motility. Observations of normal animals and of animals with experimental peritonitis. Arch Surg 33:187–196, 1936Google Scholar
  87. 87.
    Szurszewski JH: A migrating electric complex of the canine small intestine. Am J Physiol 217:1757–1763, 1969PubMedGoogle Scholar
  88. 88.
    Sarna SK: Cyclic motor activity; migrating motor complex: 1985. Gastroenterology 89:894–913, 1985PubMedGoogle Scholar
  89. 89.
    Code CF, Schlegel J: The gastrointestinal interdigestive housekeeper: motor correlates of the interdisgestive myoelectric complex of the dog.In Proceedings of the Fourth International Symposium on GI Motility. EE Daniel (ed). Vancouver, Mitchell Press, 1973Google Scholar
  90. 90.
    Bueno L, Ferre JP, Ruckebusch Y: Effects of anesthesia and surgical procedures on intestinal myoelectric activity in rats. Am J Dig Dis 23:690–695, 1978PubMedGoogle Scholar
  91. 91.
    Condon RE, Cowles V, Ekbom GA, Schulte WJ, Hess G: Effects of halothane, enflurane and nitrous oxide on colon motility. Surgery 101:81–85, 1987PubMedGoogle Scholar
  92. 92.
    Bueno L, Fioramonti J, Ruckebusch Y: Postoperative intestinal motility in dogs and sheep. Am J Dig Dis 23:682–689, 1978PubMedGoogle Scholar
  93. 93.
    Gelman S, Feigenberg Z, Dintzman M, Levy E: Electroenterography after cholecystectomy. The role of high epidural anesthesia. Arch Surg 112:580–583, 1977PubMedGoogle Scholar
  94. 94.
    Baker LW, Webster DR: Postoperative intestinal motility: An experimental study on dogs. Br J Surg 55:374–378, 1968PubMedGoogle Scholar
  95. 95.
    Wells C, Tinckler L, Rawlinson K, Jones H, Saunders J: Post-operative gastrointestinal motility. Lancet 1:4–10, 1964Google Scholar
  96. 96.
    Dauchel J, Schang JC, Kachelhoffer J, Eloy R, Grenier JF: Gastrointestinal myoelectric activity during the postoperative period in man. Digestion 14:293–303, 1976PubMedGoogle Scholar
  97. 97.
    Sarna SK, Bowes KL, Daniel EE: Postoperative gastric electrical control activity (ECA) in man.In Proceedings of the Fourth Annual International Symposium on Gastrointestinal Motility. EE Daniel (ed). Vancouver, Mitchell Press, 1973, pp 73–83Google Scholar
  98. 98.
    McCoy EJ, Baker RD: Effect of feeding on electrical activity of dog's small intestine. Am J Physiol 214:1291–1295, 1968PubMedGoogle Scholar
  99. 99.
    Anonymous: Postoperative ileus. Lancet 2:1186-1187, 1978Google Scholar
  100. 100.
    Sarna SK, Bardakjian BE, Waterfall WE, Lind JF: Human electrical control activity (ECA). Gastroenterology 78:1526–1536, 1980PubMedGoogle Scholar
  101. 101.
    Woods JH, Erickson LW, Condon RE, Schulte WJ, Sillin LF: Postoperative ileus: A colonic problem? Surgery 84:527–533, 1978PubMedGoogle Scholar
  102. 102.
    Kussmaul CA: Heilung von ileus durch Magenaüsspulung. Berl Klin Wochenschr 21:669–685, 1884Google Scholar
  103. 103.
    Eade GG, Metheny D, Lundmark VO: An evaluation of the practice of routine postoperative nasogastric suction. Surg Gynecol Obstet 101:275–279, 1955PubMedGoogle Scholar
  104. 104.
    Colvin DB, Lee W, Eisenstat TE, Rubin RJ, Salvati EP: The role of nasointestinal intubation in elective colonic surgery. Dis Colon Rectum 29:295–299, 1986PubMedGoogle Scholar
  105. 105.
    Richter HM, Kelly KA: Effect of transection and pacing on human jejunal pacesetter potentials. Gastroenterology 91:1380–1385, 1986PubMedGoogle Scholar
  106. 106.
    Bilgutay AM, Wingrove R, Griffen WO, Bannabeau RC, Lillehei CW: Gastrointestinal pacing. A new concept in the treatment of ileus. Ann Surg 58:338–348, 1963Google Scholar
  107. 107.
    Berger T, Kewenter J, Kock NG: Response to gastrointestinal pacing: Antral, duodenal and jejunal motility in control and postoperative patients. Ann Surg 164:139–144, 1966PubMedGoogle Scholar
  108. 108.
    Quast DC, Beall AC, De Bakey ME: Clinical evaluation of the gastrointestinal pacer. Surg Gynecol Obstet 120:35–37, 1965PubMedGoogle Scholar
  109. 109.
    Barker P, Allcutt D, McCollum CN: Pulsed electromagnetic energy fails to prevent postoperative ileus. J R Coll Surg Edinburgh 29:147–150, 1984Google Scholar
  110. 110.
    Smith MK, Jepson RP, Catchpole BN: Ileus: an experimental study. Br J Surg 52:381–386, 1965PubMedGoogle Scholar
  111. 111.
    Heimbach DM, Crout JR: Treatment of paralytic ileus with adrenergic neuronal blocking drugs. Surgery 69:582–587, 1971PubMedGoogle Scholar
  112. 112.
    Rada O, Stoicu G, Russo I: Influence of alpha and beta blocking agents on recovery of intestinal transit and postoperative complications in aged patients. Rev Chir 27:71–77, 1979Google Scholar
  113. 113.
    Catchpole BN: Treatment of ileus. Surgery 71:313–314, 1972Google Scholar
  114. 114.
    Thorup J, Wille Jorgensen P, Jorgensen T, Kjaergaard J: Dyhydroergotamine in postoperative ileus. Clin Pharm Ther 34:54–55, 1983Google Scholar
  115. 115.
    Petri G, Szenohradszky J, Porszasz-Gibiszer K: Sympatholytic treatment of paralytic ileus. Surgery 70:359–367, 1971PubMedGoogle Scholar
  116. 116.
    Ruwart MJ, Klepper MS, Rush BD: Mechanism of stimulation of gastrointestinal propulsion in postoperative ileus rats of 16, 16-dimethyl PGE2. Adv Prostaglandin Thromboxane Res 8:1609–1610, 1980PubMedGoogle Scholar
  117. 117.
    Ruwart MJ, Klepper MS, Rush BD: Prostaglandin stimulation of gastrointestinal transit in post-operative ileus rats. Prostaglandins 19:415–426, 1980PubMedGoogle Scholar
  118. 118.
    Gromljez PF, Kaminski DL, Willman VL: The effects of prostaglandins on experimental paralytic ileus. Surg Forum 26:400, 1977Google Scholar
  119. 119.
    Fiedler L: PGF—a new therapy for paralytic ileus? Adv Prostaglandin Thromboxane Res 8:1609–1610, 1980PubMedGoogle Scholar
  120. 120.
    Ruwart MJ, Klepper MS, Rush BD: Carbachol stimulation of gastrointestinal transit in the postoperative ileus rat. J Surg Res 26:18–26, 1979PubMedGoogle Scholar
  121. 121.
    Kleinfeld D: Edrophonium used for vagotonic action. JAMA 223:922–923, 1973Google Scholar
  122. 122.
    Polacek MA, Close AS, Ellison EH: Double blind study of the effect of pantothenyl alcohol on experimental postoperative ileus. Surg Forum 11:325–327, 1960PubMedGoogle Scholar
  123. 123.
    Garvey RF, Wilson BJ: Clinical appraisal ofd-pantothenyl alcohol in postoperative ileus: A double-blind study. Arch Surg 83:916–920, 1961PubMedGoogle Scholar
  124. 124.
    Wayne AL, Mendoza C, Rosen R, Nadler S, Case R: The role of dexanthenol in postoperative ileus. JAMA 181:827–830, 1962PubMedGoogle Scholar
  125. 125.
    Ingram DM, Catchpole BN: Effect of opiates on gastroduodenal motility following surgical operation. Dig Dis Sci 26:989–992, 1981PubMedGoogle Scholar
  126. 126.
    Yukioka H, Bogod DG, Rosen M: Recovery of bowel motility after surgery. Detection of time of first flatus from carbon dioxide concentration and patient estimate after nalbuphine and placebo. Br J Anesth 59:581–584, 1987Google Scholar
  127. 127.
    Albibi R, McCallum RW: Metoclopramide: Pharmacology and clinical application. Ann Intern Med 98:86–95, 1983PubMedGoogle Scholar
  128. 128.
    Rennie JA, Christofides ND, Mitchenere P, Fletcher D, Stockley-Leathard HL, Bloom SR, Johnson AG, Harding-Rains AJ: Neural and humerol factors in postoperative ileus. Br J Surg 67:694–698, 1980PubMedGoogle Scholar
  129. 129.
    Ruppin H, Kirndorfer D, Domschke S, Schwemmle K, Wunsch E, Demling L: Effect of 13-Nle-motilin in postoperative ileus patients: A double blind trial. Scand J Gastroenterol 39:89–92, 1976Google Scholar
  130. 130.
    Achem Karem SR, Funakoshi A, Vinik AI, Owyang C: Plasma motilin concentration and interdigestive migrating motor complex in diabetic gastroparesis: Effect of metoclopramide. Gastroenterology 88:492–499, 1985PubMedGoogle Scholar
  131. 131.
    Brevick H, Lind B: Anti-emetic and propulsive peristaltic properties of metoclopramide. Br J Anesth 43:400–402, 1971Google Scholar
  132. 132.
    Davidson ED, Hersh T, Brinner RA, Barnett SM, Boyle LP: The effects of metoclopramide on postoperative ileus. A randomized double-blind study. Ann Surg 190:27–30, 1979PubMedGoogle Scholar
  133. 133.
    Jepsen S, Klaerke A, Nielson PH, Simonsen O: Negative effect of Metoclopramide in postoperative adynamic ileus. A prospective randomized, double blind study. Br J Surg 73:290–291, 1986PubMedGoogle Scholar
  134. 134.
    Smout AJPM, Bogaard JW, Grade AC, Ten Thije OJ, Akkermans LMA, Wittebol P: Effects of cisapride, a new gastrointestinal prokinetic substance, on interdigestive and postprandial motor activity of the distal oesopahagus in man. Gut 26:246–251, 1985PubMedGoogle Scholar
  135. 135.
    Stacher G, Steinringer H, Schneider C, Winklehner S, Mittelbach G, Gaupmann G: Effects of Cisapride on jejunal motor activity in fasting healthy humans. Gastroenterology 90:1210–1226, 1986PubMedGoogle Scholar
  136. 136.
    Verlinden M, Michiels G, Boghaert A, de Coster M, Dehertog P: Treatment of postoperative gastrointestinal atony. Br J Surg 74:614–617, 1987PubMedGoogle Scholar
  137. 137.
    Bertaccini G, Agosti A: Action of Caerulein on intestinal motility in man. Gastroenterology 60:55–63, 1971PubMedGoogle Scholar
  138. 138.
    Agosti A, Bertaccini G, Paulucci R, et al: Caerulein treatment for paralytic ileus. Lancet 1:395, 1971Google Scholar
  139. 139.
    Watkins DT, Robertson CL: Water-soluble radiocontrast material in the treatment of postoperative ileus. Am J Obstet Gynecol 152:450–455, 1985PubMedGoogle Scholar
  140. 140.
    Moss G: Discharge within twenty-four hours of elective cholecystectomy. Arch Surg 121:1159–1161, 1986PubMedGoogle Scholar
  141. 141.
    Moss G: Postoperative ileus is an avoidable complication. Surg Gynecol Obstet 148:81–82, 1979PubMedGoogle Scholar
  142. 142.
    Frankel AM, Horowitz GD: Nasoduodenal tubes in shortstay cholecystectomy. Surg Gynecol Obstet 168:433–436, 1989PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1990

Authors and Affiliations

  • Edward H. Livingston
    • 1
    • 2
  • Edward P. PassaroJR
    • 1
    • 2
  1. 1.Surgical Service, West Los Angeles Veterans Administration Medical CenterUCLALos Angeles
  2. 2.Center for Ulcer Research and EducationLos Angeles

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