Effect of antacid treatment on endogenous prostaglandin synthesis in human antral and duodenal mucosa
Using14C-labeled arachidonic acid as precursor for in vitro prostaglandin synthesis, the effect of an antacid containing Al (OH)3, Mg(OH)2 and CaCO3 on endogenous prostaglandin synthesis was investigated in antral and duodenal mucosa of healthy volunteers. After three weeks of treatment with a high-dose antacid, there was no detectable change in the total capacity of the mucosa for prostaglandin synthesis, but the prostaglandin profile was markedly altered. The relative amounts of PGE2 and PGF2α synthesized by antral and duodenal mucosa increased at the expense of the prostaglandinsA2/B2, thromboxane A2, and prostacyclin. In a short-term study, this change was not observed following a single antacid dose within 1 hr after application. It is concluded that long-term antacid treatment may alter the prostaglandin pattern formed by gastroduodenal mucosa and this may be related to its therapeutic effect.
Key wordshuman stomach duodenum mucosa prostaglandin synthesis antacids
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- 1.Isenberg JI, Peterson WL, Elashoff JD, Sandersfeld MA, Reedy TJ, Ippoliti AF, Van Deventer GM, Frankl H, Longstreth GF, Anderson DS: Healing of benign gastric ulcer with low-dose antacid or cimetidine. A double-blind, randomized, placebo-controlled trial. N Engl J Med 308:1319–1324, 1983PubMedGoogle Scholar
- 2.Englert E, Freston JW, Graham DY, Finkelstein W, Kruss DM, Priest RJ, Raskin JB, Rhodes JB, Rogers AI, Wenger J, Wilcox LL, Crossley RJ: Cimetidine, antacid, and hospitalization in the treatment of benign gastric ulcer. A multicenter double blind study. Gastroenterology 74:416–425, 1978PubMedGoogle Scholar
- 5.Etienne A, Fimmel CJ, Rey JP, Blum AL: Long-lasting effect of an Al/Mg liquid antacid on nocturnal intragastric acidity recorded by continuous pH-metry. Gastroenterology 86:1071, 1984Google Scholar
- 6.Berstad A, Rydning A, Aadland E, Kolstad B, Frislid K, Aaseth J: Controlled clinical trial of duodenal ulcer healing with antacid tablets. Scan J Gastroenterol 17:953–959, 1982Google Scholar
- 7.Lam SK, Lam KC, Lai CL, Yeung CK, Yam LYC, Wong WS: Treatment of duodenal ulcer with antacid and Sulpiride. A double-blind controlled study. Gastroenterology 76:315–322, 1978Google Scholar
- 8.Hagel J, Renner H, Hirsch M, Weig G, Kaduk B, Ruppin H, Domschke W: Gastric cytoprotection by antacids and Papaverine in rats. Hepato-Gastroenterol 29:271–274, 1982Google Scholar
- 11.Reimann H-J, Schmidt U, Wendt P, Dorsch W, Von Sanden H, Von der Ohe M, Lewin J, Ultsch B: Die Wirkung von Antazida auf den Gehalt von Gewebshistamin und Prostaglandinen (PGE2) in der Magenmukosa. Fortschr Med 102:25–26, 1984Google Scholar
- 18.Preclik G, Stange EF, Kraft O, Arnold D, Schneider A, Ditschuneit H: An optimized assay for endogenous prostaglandin synthesis in rabbit and human gastrointestinal mucosa. Eur J Clin Invest 16:A29, 1986Google Scholar
- 19.Goswami SK, Kinsella JE: Separation of prostaglandins A, B, D, E, F, thromboxane and 6-keto prostaglandin F1α by thin-layer chromatography. J Chromatogr 209:334–336, 1981Google Scholar
- 20.Korte K, Casey ML: Separation of prostanoids by one-dimensional thin-layer chromatography. J Chromatogr 6:55–62, 1983Google Scholar
- 21.Stange EF, Preclik G, Ditschuneit H: Prostaglandin biosynthesis in gastroduodenal mucosa: Methodological difficulties and their implications. Scand J Gastroenterol 21:121–125, 1986Google Scholar
- 24.Whittle BJR: Cellular mediators in gastric damage: Actions of thromboxane A2 and its inhibitors.In Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract. A Allen, et al (eds). New York, Raven Press, pp 295–301, 1984Google Scholar