Digestive Diseases and Sciences

, Volume 33, Issue 8, pp 993–998 | Cite as

Clinical evaluation of methylcellulose as a bulk laxative

  • John W. Hamilton
  • Joanne Wagner
  • Babette B. Burdick
  • Paul Bass
Original Articles

Abstract

We studied a bulk laxative containing methylcellulose in a group of normal subjects as well as in a group of chronically constipated individuals. The initial study in normal subjects was performed to show that the compound could increase fecal weight without significant side effects. Fifty healthy subjects were studied. Methylcellulose in daily doses of 4 g demonstrated a statistically significant increase in fecal frequency, fecal water, and fecal solids. In the second phase, we studied a group of 59 chronically constipated individuals treated with daily doses of the laxative containing either 1, 2, or 4 g of methylcellulose or 3.4 g psyllium. All of these doses resulted in statistically significant increases in stool frequency, water content, and fecal solids. There was no increase in individual stool weight from any of the laxative doses. Methylcellulose, in a daily dose as low as 1 g, is an effective laxative.

Key words

methyl cellulose constipation bulk laxative psyllium 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Tainter ML: Methylcellulose as a colloid laxative. Proc Soc Exp Biol Med 54:77–79, 1943Google Scholar
  2. 2.
    Knight HF, Hodge HC, Samsei EP, DeLap RE, McCallister DD: Studies on single oral doses of a high gel point methylcellulose. J Am Pharm Assoc 41:427–429, 1953Google Scholar
  3. 3.
    Lehman AJ: The colloidal laxative. Modern Hosp 64:98–102, 1945Google Scholar
  4. 4.
    Laxative drug products for over-the-counter human use: Tentative final monograph. Fed Regist 50:2124-2158, 1985Google Scholar
  5. 5.
    Bass P, Dennis S: The laxative effects of lactulose in normal and constipated subjects. J Clin Gastroenterol 3:23–28, 1981Google Scholar
  6. 6.
    Marlett JA, Li BUK, Patrow CJ, Bass P: Comparative laxation of psyllium with and without senna in an ambulatory constipated population. Am J Gastroenterol 82:333–337, 1987PubMedGoogle Scholar
  7. 7.
    Johnson EJ, Marlett JA: A simple method to estimate neutral detergent fiber (NDF) content in typical daily menus. Am J Clin Nutr 44:127–134, 1986PubMedGoogle Scholar
  8. 8.
    Devroede G: Constipation: Mechanisms and management.In Gastrointestinal Disease, (eds). MH Sleisenger, JS Fordtran. Philadelphia, WB Saunders, 1983, pp 288–308Google Scholar
  9. 9.
    Berger FM; Ludwig BS; Wielich KH: The hydrophilic and acid binding properties of Alginates. Am J Dig Dis 20:39–42, 1953PubMedGoogle Scholar
  10. 10.
    Connell AM, Hilton C, Irvine G, Lennard-Jones JE, Misiewicz JJ: Variation in bowel habit in two population samples. Br Med J 2:1095–1099, 1965Google Scholar
  11. 11.
    Rentorff RC, Kashgarian M: Stool parameters of healthy adult males. Dis Colon Rectum 10:222–228, 1967PubMedGoogle Scholar
  12. 12.
    Shoulder P, Keighley MRB: Changes in colorectal function in severe idiopathic chronic constipation. Gastroenterology 90:414–420, 1986PubMedGoogle Scholar
  13. 13.
    Martelli H, Devroede G, Arhan P, Dugway C, Dornic C, Faverdin C: Some parameters of large bowel motility in normal man. Gastroenterology 75:612–618, 1978PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1988

Authors and Affiliations

  • John W. Hamilton
    • 1
    • 2
  • Joanne Wagner
    • 1
    • 2
  • Babette B. Burdick
    • 1
    • 2
  • Paul Bass
    • 1
    • 2
  1. 1.Department of Medicine and the School of PharmacyUniversity of WisconsinMadison
  2. 2.Merrell Dow Research InstituteCincinnati

Personalised recommendations