Digestive Diseases and Sciences

, Volume 33, Issue 12, pp 1601–1614 | Cite as

Clinical use of serum enzymes in liver disease

  • Jacques J. Reichling
  • Marshall M. Kaplan
Review Article


Some of the many enzymes found in hepatocytes can be measured in the serum and are used as tests of liver function. We now review the current knowledge of their physiology and pathophysiology and outline their clinical usefulness. We divide them into two categories: enzymes that primarily reflect cholestasis, such as the alkaline phosphatase, the 5-nucleotidase, and the gamma-glutamyl transpeptidase, and those that primarily reflect hepatocellular necrosis, such as the aminotransferases. We also briefly discuss several enzymes of more limited usefulness.

Key words

serum enzymes liver disease 


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Copyright information

© Plenum Publishing Corporation 1988

Authors and Affiliations

  • Jacques J. Reichling
    • 1
  • Marshall M. Kaplan
    • 1
  1. 1.Gastroenterology Division, Department of MedicineNew England Medical CenterBoston

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