Digestive Diseases and Sciences

, Volume 33, Issue 9, pp 1185–1191 | Cite as

Fulminant hepatitis due to reactivation of chronic hepatitis B virus infection after allogeneic bone marrow transplantation

  • E. Alexandre Pariente
  • Alain Goudeau
  • Frédéric Dubois
  • Claude Degott
  • Elaine Gluckman
  • Agnès Devergie
  • Christian Brechot
  • Christine Schenmetzler
  • Jacques Bernuau
Case Report
Received:
Revised:
Accepted:

Summary

A case of hepatitis B reactivation following bone-marrow transplantation for leukemia in a previously healthy HBsAg carrier is reported. A number of changes in HBV serum markers were contemporary to the acute episode. All of them (increase of HBsAg concentration, conversion from anti-HBe to HBeAg, appearance of anti-HBc IgM, and of serum HBV-DNA) were suggestive of a “switching-on” of viral replication. Institution of corticosteroid treatment at the onset of the acute phase did not prevent the fatal outcome.

Key words

hepatitis B fulminant reactivation transplantation 
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Copyright information

© Plenum Publishing Corporation 1988

Authors and Affiliations

  • E. Alexandre Pariente
    • 1
    • 2
    • 3
    • 4
    • 5
  • Alain Goudeau
    • 1
    • 2
    • 3
    • 4
    • 5
  • Frédéric Dubois
    • 1
    • 2
    • 3
    • 4
    • 5
  • Claude Degott
    • 1
    • 2
    • 3
    • 4
    • 5
  • Elaine Gluckman
    • 1
    • 2
    • 3
    • 4
    • 5
  • Agnès Devergie
    • 1
    • 2
    • 3
    • 4
    • 5
  • Christian Brechot
    • 1
    • 2
    • 3
    • 4
    • 5
  • Christine Schenmetzler
    • 1
    • 2
    • 3
    • 4
    • 5
  • Jacques Bernuau
    • 1
    • 2
    • 3
    • 4
    • 5
  1. 1.Unité de recherches de Physiopathologie hépatiqueINSERM U22France
  2. 2.Laboratoire d'Anatomie et de Cytologie pathologiquesHôpital BeaujonClichy CedexFrance
  3. 3.Laboratoire de VirologieCHRU BretonneauTours CedexFrance
  4. 4.Institut de Recherches sur les maladies du sangHôpital Saint-LouisParisFrance
  5. 5.Unité de recombinaison et expression génétiqueINSERM U163, Institut PasteurParisFrance

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