Advertisement

Digestive Diseases and Sciences

, Volume 33, Issue 9, pp 1096–1102 | Cite as

Zinc plasma levels after oral zinc tolerance test in nonalcoholic cirrhosis

  • S. Karayalcin
  • A. Arcasoy
  • O. Uzunalimoglu
Original Articles

Abstract

Zinc absorption was examined in 25 nonalcoholic cirrhotic patients using the oral zinc tolerance test and comparing results to a healthy control group. With 22.5 mg elementary zinc, the increase in plasma zinc was significantly lower in the cirrhotic patients than in the control group with P<0.01 in the first and second hours and P<0.05 in the fourth hour. The zinc malabsorption may result from an abnormal small intestinal mucosa. Indeed small intestinal biopsies in all patients showed partial shortening and prominent distension of villi and intense stromal edema with inflammatory cell infiltration of the lamina propria. However, it is not clear whether these intestinal changes are due to zinc deficiency or to portal hypertension. Thus zinc malabsorption appears to contribute to zinc deficiency in nonalcoholic cirrhotics and seems to result, in part, from pathological changes in the mucosa.

Key words

zinc absorption nonalcoholic cirrhosis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Vallee BL, Wacker WEC, Bartholomay AF, Hoch FL: Zinc metabolism in hepatic dysfunction. II. Correlation of metabolic patterns with biochemical findings. N Engl J Med 257:1055–1065, 1957PubMedGoogle Scholar
  2. 2.
    Fredericks RE, Tanaka KR, Valentine WN: Zinc in human blood cells: Normal values and abnormalities associated with liver disease. J Clin Invest 39:1651–1656, 1960PubMedGoogle Scholar
  3. 3.
    Boyett JD, Sullivan JF: Zinc and collagen content of cirrhotic liver. Dig Dis Sci 15:797–802, 1970Google Scholar
  4. 4.
    Sullivan JF, Jetton MM, Burch RE: Zinc ingestion in cirrhotic patients. Am J Clin Nutr 31:718, 1978Google Scholar
  5. 5.
    Mills PR, Fell GS, Bessent RG, Nelson LM, Rusell RI: A study of zinc metabolism in alcoholic cirrhosis. Clin Sci 64:527–535, 1983PubMedGoogle Scholar
  6. 6.
    Milman N, Hvid-Jacobsen K, Hegnhoj J, Sorensen SS: Zinc absorption in patients with compensated alcoholic cirrhosis. Scand J Gastroenterol 18(7):871–875, 1983PubMedGoogle Scholar
  7. 7.
    Valberg LS, Flanagan PR, Ghent CN, Chamberlain MJ: Zinc absorption and leukocyte zinc in alcoholic and nonalcoholic cirrhosis. Dig Dis Sci 30:329–333, 1985PubMedGoogle Scholar
  8. 8.
    Solomons NW, Jacob RA: Studies on the bioavailability of zinc in humans: Effect of heme and nonheme iron on the absorption of zinc. Am J Clin Nutr 34:475–482, 1983Google Scholar
  9. 9.
    Perkin E: Clinical method for atomic absorption spectroscopy. Perkin Elmer Co., Connecticut, 1973Google Scholar
  10. 10.
    Sullivan JF: Effect of alcohol on urinary zinc excretion. Q J Stud Alcohol 23:216–220, 1962PubMedGoogle Scholar
  11. 11.
    Sullivan JF, Lankford HG: Urinary excretion of zinc in alcoholism and postalcoholic cirrhosis. Am J Clin Nutr 10:153–157, 1962PubMedGoogle Scholar
  12. 12.
    Kahn AM, Helwig HL, Redecker AG, Reynolds TB: Urine and serum zinc abnormalities in disease of the liver. Am J Clin Nutr 44:426–435, 1965Google Scholar
  13. 13.
    Evans GW, Grace CI: Homeostatic regulation of zinc absorption in the rat. Proc Soc Exp Biol Med 143:723–725, 1973PubMedGoogle Scholar
  14. 14.
    Sullivan JF, Jetton MM, Burch RE: A zinc tolerance test. J Lab Clin Med 93:485–492, 1979PubMedGoogle Scholar
  15. 15.
    Fickel JJ, Freeland-Graves JH: Zinc tolerance tests in normal and zinc depleted humans. Fed Proc 42:392–397, 1983Google Scholar
  16. 16.
    Valberg LS, Flanagan PR, Brennan J, Chamberlain MJ: Does the oral zinc tolerance test measure zinc absorption. Am J Clin Nutr 41:37–42, 1985PubMedGoogle Scholar
  17. 17.
    Crofton RW, Glower SC, Ewan SWB, Aggett PJ, Mowat NAG, Mills CF: Zinc absorption in celiac disease and dermatitis herpetiformis: A test of small intestinal function. Am J Clin Nutr 38:706–712, 1983PubMedGoogle Scholar
  18. 18.
    Freeland-Graves JH, Ebangit ML, Hendrikson RJ: Alterations in zinc absorption and salivary sediment zinc after a lacto-ovovegetarian diet. Am J Clin Nutr 33:1757–1766, 1980PubMedGoogle Scholar
  19. 19.
    Astaldi G, Strosselli E: Peroral biopsy of the small intestinal mucosa in hepatic cirrhosis. Am J Dig Dis 5:603–612, 1960PubMedGoogle Scholar
  20. 20.
    Sun DCH, Albacete RA, Chen JK: Malabsorption studies on cirrhosis of liver. Arch Intern Med 119:567–572, 1967PubMedGoogle Scholar
  21. 21.
    Kelly R, Davidson GP, Townley RRW, Campbell PE: Reversible intestinal mucosal abnormality in acrodermatitis enteropathica. Arch Dis Child 51:219–222, 1976PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1988

Authors and Affiliations

  • S. Karayalcin
    • 1
  • A. Arcasoy
    • 1
  • O. Uzunalimoglu
    • 1
  1. 1.Department of Gastroenterology, Faculty of MedicineAnkara UniversityAnkaraTurkey

Personalised recommendations