Somatic Cell and Molecular Genetics

, Volume 15, Issue 2, pp 143–152 | Cite as

TheIL-4 andIL-5 genes are closely linked and are part of a cytokine gene cluster on mouse chromosome 11

  • Janet S. Lee
  • Hugh D. Campbell
  • Christine A. Kozak
  • Ian G. Young


The murine IL-4and IL-5genes encode hemopoietic growth factors involved in the stimulation, proliferation, and differentiation of cells of the T lymphocyte, B lymphocyte, and granulocyte lineages. We have mapped the Il-4 and Il-5 loci representing the structural genes for IL-4and IL-5,respectively, to mouse chromosome 11 using Chinese hamster ×mouse and rat × mouse somatic cell hybrids. Physical linkage studies of the IL-4and IL-5genes by pulsed field gel electrophoresis have shown that they are closely linked, being 110–180 kb apart. Since the Il-5 locus maps to the interface of bands A5 and B1 in the same location as the genes for IL-3and GM-CSF, this places these three cytokine genes, as well as the IL-4 gene, within a region of about 5000–10,000 kb. The present physical linkage studies indicate that the IL-4and IL-5genes are a minimum of 600 kb apart from the closely linked IL-3and GM-CSFgenes. The gene clustering, together with similarities in gene structure, regulation, and biological function, raises the possibility that the four genes may be part of a distantly related cytokine gene family.


Gene Family Gene Cluster Biological Function Somatic Cell Gene Structure 
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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Janet S. Lee
    • 1
  • Hugh D. Campbell
    • 1
  • Christine A. Kozak
    • 2
  • Ian G. Young
    • 1
  1. 1.Medical Molecular Biology, John Curtin School of Medical ResearchAustralian National UniversityCanberraAustralia
  2. 2.Laboratory of Viral DiseasesNational Institute of Allergy and Infectious Diseases, National Cancer InstituteBethesda

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