Genes for human vitamin K-dependent plasma proteins C and S are located on chromosomes 2 and 3, respectively
- Cite this article as:
- Long, G.L., Marshall, A., Gardner, J.C. et al. Somat Cell Mol Genet (1988) 14: 93. doi:10.1007/BF01535052
cDNAs encoding human proteins C and S have been used to screen a panel of mouse-human somatic cell hybrids to determine the chromosomal location of their respective genes. The gene for human protein C is located on chromosome 2, whereas that for protein S is located on chromosome 3. Analysis of human genomic DNA restriction endonuclease fragmentation patterns suggests that the human protein S gene is greater than 40 kb in size and contains a minimum of 11 introns.