Somatic Cell and Molecular Genetics

, Volume 15, Issue 4, pp 297–307

Human gene for proliferating cell nuclear antigen has pseudogenes and localizes to chromosome 20

  • De-Hui Ku
  • Salvatore Travali
  • Bruno Calabretta
  • Kay Huebner
  • Renato Baserga


We have isolated from a human genomic library a pseudogene of the proliferating cell nuclear antigen (PCNA)gene. Its sequence shows a 78% similarity with the human PCNA/cDNA. The PCNAgene is located on human chromosome 20, while the pseudogene maps to chromosome region Xpter→Xq13. An additional locus detected by the full-length PCNA cDNA, but not by intron probes, segregates concordantly with chromosome region 6p12→6pter and probably represents a second pseudogene.


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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • De-Hui Ku
    • 1
  • Salvatore Travali
    • 1
  • Bruno Calabretta
    • 1
  • Kay Huebner
    • 1
  • Renato Baserga
    • 1
  1. 1.Department of Pathology and Fels Institute for Cancer Research and Molecular BiologyTemple University School of MedicinePhiladelphia

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