Somatic Cell and Molecular Genetics

, Volume 11, Issue 2, pp 149–155 | Cite as

Chromosomal localization of three humanras genes by in situ molecular hybridization

  • N. C. Popescu
  • S. C. Amsbaugh
  • J. A. DiPaolo
  • S. R. Tronick
  • S. A. Aaronson
  • D. C. Swan


Three human rasfamily protooncogenes, c-Ki-ras-1, and c-Ki-ras-2, and N-ras,have been mapped to chromosome bands 6p11–12, 12p11.1–12.1, and 1p11–13, respectively by in situ molecular hybridization. Certain human cancers display consistent and specific alterations involving chromosomes 1, 6, and 12. The precise chromosomal localization of ras genes will permit evaluation of thepossible effect of these chromosome changes on the structure and activities of ras protooncogenes in human neoplasia.


Human Cancer Chromosomal Localization Chromosome Band Chromosome Change Specific Alteration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Literature cited

  1. 1.
    Weinberg, R.A. (1982).Cell 30:3–4.PubMedGoogle Scholar
  2. 2.
    Cooper, G.M. (1982).Science 217:801–806.PubMedGoogle Scholar
  3. 3.
    Pulciani, S., Santos, E., Lauver, A.V., Long, L.K., Aaronson, S.A., and Barbacid, M. (1982).Nature 300:539–542.PubMedGoogle Scholar
  4. 4.
    Santos, E., Tronick, S.R., Aaronson, S.A., Pulciani, S., and Barbacid, M. (1982).Nature 298:343–347.PubMedGoogle Scholar
  5. 5.
    Der, C.J., Krontiris, T.G., and Cooper, G.M. (1982).Proc. Natl. Acad. Sci. U.S.A. 79:3637–3640.PubMedGoogle Scholar
  6. 6.
    Shimizu, K., Goldfarb, M., Perucho, M., and Wigler, M. (1983).Proc. Natl. Acad. Sci. U.S.A. 80:383–387.PubMedGoogle Scholar
  7. 7.
    Parada, L.F., Tabin, C.J., Shih, C., and Weinberg, R.A. (1982).Nature 297:474–478.PubMedGoogle Scholar
  8. 8.
    Eva, A., Tronick, S.R., Gol, R.A., Pierce, J.H., and Aaronson, S.A. (1983).Proc. Natl. Acad. Sci. U.S.A. 80:4926–4930.PubMedGoogle Scholar
  9. 9.
    Chang, E.H., Gonda, M.A., Ellis, R.W., Scolnick, E.M., and Lowy, D.R. (1982).Proc. Natl. Acad. Sci. U.S.A. 79:4848–4852.PubMedGoogle Scholar
  10. 10.
    Taparowsky, E., Shimizu, K., Goldfarb, M., and Wigler, M. (1983).Cell 34:581–586.PubMedGoogle Scholar
  11. 11.
    Shimizi, K., Birnbaum, D., Ruley, M.A., Fasano, O., Suard, Y., Edlund, L., Taparowsky, E., Goldfarb, M., and Wigler, M. (1983).Nature 304:497–500.PubMedGoogle Scholar
  12. 12.
    Reddy, E.P. (1983).Science 220:1061–1063.PubMedGoogle Scholar
  13. 13.
    Capon, D.J., Seeburg, P.H., McGrath, J.P., Hayflick, J.S., Edman, U., Levinson, A.D., and Goeddel, D.V. (1983).Nature 304:507–513.PubMedGoogle Scholar
  14. 14.
    McGrath, J.P., Capon, D.J., Smith, D.H., Chen, E.Y., Seeburg, P.H., Goeddel, D.V., and Levinson, A.D. (1983).Nature 304:501–506.PubMedGoogle Scholar
  15. 15.
    Yuasa, Y., Gol, R.A., Chang, A., Chiu, I.M., Reddy, E.P., Tronick, S.R., and Aaronson, S.A. (1984).Proc. Natl. Acad. Sci. U.S.A. 81:3670–3674.PubMedGoogle Scholar
  16. 16.
    Santos, E., Martin-Zanca, D., Reddy, E.P., Pierotti, M.A., Della Porta, G.,and Barbacid, M. (1984).Science 223:661–664.PubMedGoogle Scholar
  17. 17.
    Reddy, E.P., Reynolds, R.K., Santos, E., and Barbacid, M. (1982).Nature 300:149–152.PubMedGoogle Scholar
  18. 18.
    Taparowsky, E., Suard, Y., Fasano, O., Shimizu, K., Goldfarb, M., and Wigler, M. (1982).Nature 300:762–765.PubMedGoogle Scholar
  19. 19.
    Tabin, C.J., Bradley, S.M., Bargmann, C.I., Weinberg, R.A., Papageorge, A.G., Scolnick, E.M., Dhar, R., Lowy, D.R., and Chang, E.H. (1982).Nature 300:143–149.PubMedGoogle Scholar
  20. 20.
    Yuasa, Y., Srivastava, S.K., Dunn, C.Y., Rhin, J.S., Reddy, E.P., and Aaronson, S.A. (1983).Nature 303:775–779.PubMedGoogle Scholar
  21. 21.
    Fujita, J., Yoshida, O., Yuasa, Y., Rhim, J., Hatanaka, M., and Aaronson, S.A. (1984).Nature 309:464–466.PubMedGoogle Scholar
  22. 22.
    Kraus, M., Yuasa, Y., and Aaronson, S.A. (1984).Proc. Natl. Acad. Sci. U.S.A. 17:5384–5389.Google Scholar
  23. 23.
    Chang, E.H., Furth, M.E., Scholnick, E.M., and Lowy, D.R. (1982).Nature 297:479–483.PubMedGoogle Scholar
  24. 24.
    Stacey, D.W., and Kung, H.F. (1984).Nature 310:508–511.PubMedGoogle Scholar
  25. 25.
    McBride, O.W., Swan, D.C., Tronick, S.R., Gol, R., Klimanis, D., Moore, D.E., and Aaronson, S.A. (1983).Nucleic Acids Res. 11:8221–8236.PubMedGoogle Scholar
  26. 26.
    Yunis, J.J. and Chandler, M.E. (1977). InProgress in Clinical Pathology, Vol. VII, (eds.) Stefanini, M., Hossaini, A.A., and Isenberg, H.D. (Grune and Stratton, New York), pp. 267–288.Google Scholar
  27. 27.
    Harper, M.E., and Saunders, G.F. (1981).Chromosoma (Berlin) 83:431–439.Google Scholar
  28. 28.
    Chandler, M.E., and Yunis, J.J. (1978).Cytogenet. Cell Genet. 22:352–356.PubMedGoogle Scholar
  29. 29.
    ISCN (1981).An International System for Human Cytogenetic Nomenclature—High-Resolution Banding (1981) Birth Defects: Original Article Series, Vol. 17, No. 5 (March of Dimes Birth Defects Foundation, New York).Google Scholar
  30. 30.
    O'Brien, S.J., Nash, W.G., Goodwin, J.L., Lowy, D.R., and Chang, E.H. (1983).Nature 302:839–842.PubMedGoogle Scholar
  31. 31.
    Ryan, J., Barker, P.E., Shimizu, K., Wigler, M., and Ruddle, F.H. (1983).Proc. Natl. Acad. Sci. U.S.A. 80:4460–4463.PubMedGoogle Scholar
  32. 32.
    Sakaguchi, A.Y., Naylor, S.L., Shows, T.B., Toole, J.J., McCoy, M., and Weinberg, R.A. (1983).Science 219:1081–1083.PubMedGoogle Scholar
  33. 33.
    Jhanwar, S.C., Neel, B.G., Hayward, W.S., and Chaganti, R.S.K. (1983).Proc. Natl. Acad. Sci. U.S.A. 80:4794–4797.PubMedGoogle Scholar
  34. 34.
    Huerre, C., Despoisse, S., Gilgenkrantz, S., Lenoir, G.M., and Junien, C. (1983).Nature 305:638–641.PubMedGoogle Scholar
  35. 35.
    de Martinville, B., Giacalone, J., Shih, C., Weinberg, R.A., and Francke, U. (1983).Science 219:498–501.PubMedGoogle Scholar
  36. 36.
    Fearon, E.R., Antonarakis, S.E., Meyers, D.A., and Levine, M.A. (1984).Am. J. Hum. Genet. 36:329–337.PubMedGoogle Scholar
  37. 37.
    Comings, D.E. (1972).Nature 238:455–457.PubMedGoogle Scholar
  38. 38.
    de Martinville, B., Cunningham, J.M., Murray, M.J., and Francke, U. (1983).Nucleic Acid Res. 11:5267–5275.PubMedGoogle Scholar
  39. 39.
    Hall, A., Marshall, C.J., Spurr, N.K., and Weiss, R.A. (1983).Nature 303:396–400.PubMedGoogle Scholar
  40. 40.
    Davis, M., Malcolm, S., Hall, A., and Marshall, C.J. (1983).EMBO J. 2:2281–2283.PubMedGoogle Scholar
  41. 41.
    Rabin, M., Watson, M., Barker, P.E., Ryan, J., Breg, W.R., and Ruddle, F.H. (1984).Cytogenet. Cell Genet. 38:70–72.PubMedGoogle Scholar
  42. 42.
    Rowley, J.D. (1983).Nature 301:290–291.PubMedGoogle Scholar
  43. 43.
    Lebeau, M.M., and Rowley, J.D. (1984).Nature 308:607–608.PubMedGoogle Scholar
  44. 44.
    Mitelman, F., and Levan, G. (1981).Hereditas 95:79–139.PubMedGoogle Scholar
  45. 45.
    Yunis, J.J. (1983).Science 221:227–236.PubMedGoogle Scholar
  46. 46.
    Balaban, G., and Gilbert, F. (1982).Cancer Res. 42:1832–1842.Google Scholar
  47. 47.
    Babapulle, V.B., and Atkin, N.B. (1981).Cancer Genet. Cytogenet. 4:215–225.PubMedGoogle Scholar
  48. 48.
    Haag, M.M., Soukup, S.W., and Neeley, J.E. (1981).Cancer Res. 41:2995–2999.PubMedGoogle Scholar
  49. 49.
    Brodeur, G.M., Green, A.A., Hayes, F.A., Williams, K.J., Williams, D.L., and Tsiatis, A.A. (1981).Cancer Res. 41:4678–4686.PubMedGoogle Scholar
  50. 50.
    Gilbert, F., Balaban, G., Moorhead, P., Bianchi, D., and Schlesinger, H. (1982).Cancer Genet. Cytogenet. 7:33–42.PubMedGoogle Scholar
  51. 51.
    Benedict, W.F., Banerjee, A., Mark, C., and Murphree, A.L. (1983).Cancer Genet. Cytogenet. 10:311–333.PubMedGoogle Scholar
  52. 52.
    Squire, J., Phillips, R.A., Boyce, S., Godbout, R., Rogers, B., and Gallie, B.L. (1984).Hum. Genet. 66:46–53.PubMedGoogle Scholar
  53. 53.
    Becher, R., Gibas, Z., Karakousis, C., and Sandberg, A.A. (1983).Cancer Res. 43:5010–5016.PubMedGoogle Scholar
  54. 54.
    Becher, R., Gibas, Z. and Sandberg, A.A. (1982).Cancer Genet. Cytogenet. 5:173–179.PubMedGoogle Scholar
  55. 55.
    Lewis, M.G., Ikonopisov, R.L., Nairn, R.C., Phillips, T.M., Fairley, G.H., Bodenham, D.C., and Alexander, P. (1969).Br. Med. J. 3:547–552.PubMedGoogle Scholar
  56. 56.
    Mavligit, G., Gutterman, J.U., McBride, C., and Hersh, E.M. (1974).Prog. Exp. Tumor Res. 19:222–252.PubMedGoogle Scholar
  57. 57.
    Francke, U., and Pellegrino, M.A. (1977).Proc. Natl. Acad. Sci. U.S.A. 74:1147–1151.PubMedGoogle Scholar
  58. 58.
    Schwab, M., Alitalo, K., Varmus, H.E., and Bishop, J.M. (1983).Nature 303:497–501.PubMedGoogle Scholar
  59. 59.
    Reeve, A.E., Housiaux, P.J., Gardner, R.J.M., Chewings, W.E., Grindley, R.M., and Millow, L.J. (1984).Nature 309:174–176.PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • N. C. Popescu
    • 1
  • S. C. Amsbaugh
    • 1
  • J. A. DiPaolo
    • 1
  • S. R. Tronick
    • 2
  • S. A. Aaronson
    • 2
  • D. C. Swan
    • 2
  1. 1.Laboratory of Biology, National Cancer InstituteNational Institutes of HealthBethesda
  2. 2.Cellular and Molecular Biology, National Cancer InstituteNational Institutes of HealthBethesda

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