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Somatic Cell and Molecular Genetics

, Volume 11, Issue 2, pp 149–155 | Cite as

Chromosomal localization of three humanras genes by in situ molecular hybridization

  • N. C. Popescu
  • S. C. Amsbaugh
  • J. A. DiPaolo
  • S. R. Tronick
  • S. A. Aaronson
  • D. C. Swan
Article

Abstract

Three human rasfamily protooncogenes, c-Ki-ras-1, and c-Ki-ras-2, and N-ras,have been mapped to chromosome bands 6p11–12, 12p11.1–12.1, and 1p11–13, respectively by in situ molecular hybridization. Certain human cancers display consistent and specific alterations involving chromosomes 1, 6, and 12. The precise chromosomal localization of ras genes will permit evaluation of thepossible effect of these chromosome changes on the structure and activities of ras protooncogenes in human neoplasia.

Keywords

Human Cancer Chromosomal Localization Chromosome Band Chromosome Change Specific Alteration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • N. C. Popescu
    • 1
  • S. C. Amsbaugh
    • 1
  • J. A. DiPaolo
    • 1
  • S. R. Tronick
    • 2
  • S. A. Aaronson
    • 2
  • D. C. Swan
    • 2
  1. 1.Laboratory of Biology, National Cancer InstituteNational Institutes of HealthBethesda
  2. 2.Cellular and Molecular Biology, National Cancer InstituteNational Institutes of HealthBethesda

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