Somatic Cell and Molecular Genetics

, Volume 13, Issue 6, pp 679–684

Human gene coding for granulocyte-colony stimulating factor is assigned to the q21-q22 region of chromosome 17

  • Naotoshi Kanda
  • Shin-ichi Fukushige
  • Tomoaki Murotsu
  • Michihiro C. Yoshida
  • Masayuki Tsuchiya
  • Shigetaka Asano
  • Yoshito Kaziro
  • Shigekazu Nagata
Brief Communication

Abstract

Granulocyte-colony stimulating factor (G-CSF) is a member of colony stimulating factors which regulate the proliferation and differentiation of hematopoietic progenitor cells. A full-length cDNA clone coding human G-CSF was used as a hybridization probe to detect homologous sequence in human-mouse somatic cell hybrids, flow-sorted human chromosomes, and in situ human metaphase chromosomes. The results indicate that the gene encoding human G-CSF is on the q21–q22 region of chromosome 17, which is involved in translocation of t(15;17) (q23;21) in human acutepromyelocytic leukemia.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature cited

  1. 1.
    Metcalf, D. (1985).Science 229:16–22.PubMedGoogle Scholar
  2. 2.
    Metcalf, D. (1986).Blood 67:257–267.PubMedGoogle Scholar
  3. 3.
    Huebner, K., Isobe, M., Croce, C.M., Golde, D.W., Kaufman, S.E., and Gasson, J.C. (1985).Science 230:1282–1285.PubMedGoogle Scholar
  4. 4.
    Le Beau, M.M., Westbrook, C.A., Diaz, M.O., Larson, R.A., Rowley, J.D., Gasson, J.C., Golde, D.W., and Sherr, C.J. (1986).Science 231:981–987.Google Scholar
  5. 5.
    Larson, R.A., Kondo, K., Vardiman, J.W., Butler, A.E., Golombo, H.M., and Rowley, J.D. (1984).Am. J. Med. 76:827–841.PubMedGoogle Scholar
  6. 6.
    Nagata, S., Tsuchiya, M., Asano, S., Kaziro, Y., Yamazaki, T., Yamamoto, O., Hirata, Y., Kubota, N., Oheda, M., Nomura, H., and Ono, M. (1986).Nature 319:415–418.PubMedGoogle Scholar
  7. 7.
    Maniatis, T., Fritsch, E.F., and Sambrook, J. (1982).Molecular Cloning, A Laboratory Manual (Cold Spring Harbor Laboratory, New York).Google Scholar
  8. 8.
    Semba, K., Yamanashi, Y., Nishizawa, M., Sukegawa, J., Yoshida, M., Sasaki, M., Yamamoto, T., and Toyoshima, K. (1985).Science 227:1038–1040.PubMedGoogle Scholar
  9. 9.
    Yoshida, M.C., Ikeuchi, T., and Sasaki, M. (1975).Proc. Jpn. Acad. 51:184–187.Google Scholar
  10. 10.
    Testa, J.R., Rowley, J.D., Hawkins, C., Yu, R.L., Aronson, M.M., Mulivor, R.A., Greene, A.E., and Coriell, L.L. (1980).Cytogenet. Cell Genet. 27:270.PubMedGoogle Scholar
  11. 11.
    Sillar, R., and Young, B.D. (1981).J. Histochem. Cytochem. 29:74–78.PubMedGoogle Scholar
  12. 12.
    Fukushige, S.-I., Murotsu, T., and Matsubara, K.-I. (1986).Biochem. Biophys. Res. Commun. 134:477–483.PubMedGoogle Scholar
  13. 13.
    Kanda, N., Schreck, R., Alt, F., Bruns, G., Baltimore, D., and Latt, S. (1983).Proc. Natl. Acad. Sci. U.S.A. 80:4069–4073.PubMedGoogle Scholar
  14. 14.
    Nagata, S., Tsuchiya, M., Asano, S., Yamamoto, O., Hirata, Y., Kubota, N., Oheda, M., Nomura, H., and Yamazaki, T. (1986).EMBO J. 5:575–581.PubMedGoogle Scholar
  15. 15.
    Tsuchiya, M., Kaziro, Y., and Nagata, S. (1987).Eur. J. Biochem. 165:7–12.PubMedGoogle Scholar
  16. 16.
    Fukushige, S.-I., Matsubara, K.-I., Yoshida, M., Sasaki, M., Suzuki, T., Semba, K., Toyoshima, K., and Yamamoto, T. (1986).Mol. Cell. Biol. 6:955–958.PubMedGoogle Scholar
  17. 17.
    Dayton, A.I., Selden, J.R., Laws, G., Dorney, D.J., Finan, J., Tripputi, P., Emanuel, B.S., Rovera, G., and Nowell, P.C. (1984).Proc. Natl. Acad. Sci. U.S.A. 81:4495–4499.PubMedGoogle Scholar
  18. 18.
    Huebner, K., Isobe, M., Chao, M., Rothwell, M., Ross, A.H., Finan, J., Hoxie, J.A., Sehgal, A., Buck, C.R., Lanahan, A., Nowell, P.C., Koprowski, H., and Croce, C.M. (1986).Proc. Natl. Acad. Sci. U.S.A. 83:1403–1407.PubMedGoogle Scholar
  19. 19.
    Barlow, D.P., Bucan, M., Lehrach, H., Hogan, B.L.M., Gough, N.M. (1987).EMBO J. 6:617–623.PubMedGoogle Scholar
  20. 20.
    Lalley, P.A., and McKusick, U.A. (1985).Cytogenet. Cell Genet. 40:536–566.PubMedGoogle Scholar
  21. 21.
    Tsuchiya, M., Asano, S., Kaziro, Y., and Nagata, S. (1986).Proc. Natl. Acad. Sci. U.S.A. 83:7633–7637.PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • Naotoshi Kanda
    • 1
  • Shin-ichi Fukushige
    • 2
  • Tomoaki Murotsu
    • 2
  • Michihiro C. Yoshida
    • 3
  • Masayuki Tsuchiya
    • 4
  • Shigetaka Asano
    • 4
  • Yoshito Kaziro
    • 4
  • Shigekazu Nagata
    • 4
  1. 1.Tokyo Women's Medical CollegeTokyoJapan
  2. 2.Institute for Molecular and Cellular BiologyOsaka UniversityOsakaJapan
  3. 3.Chromosome Research UnitHokkaido UniversitySapporoJapan
  4. 4.Institute of Medical ScienceUniversity of TokyoTokyoJapan

Personalised recommendations