Somatic Cell and Molecular Genetics

, Volume 13, Issue 6, pp 679–684

Human gene coding for granulocyte-colony stimulating factor is assigned to the q21-q22 region of chromosome 17

  • Naotoshi Kanda
  • Shin-ichi Fukushige
  • Tomoaki Murotsu
  • Michihiro C. Yoshida
  • Masayuki Tsuchiya
  • Shigetaka Asano
  • Yoshito Kaziro
  • Shigekazu Nagata
Brief Communication

DOI: 10.1007/BF01534488

Cite this article as:
Kanda, N., Fukushige, S., Murotsu, T. et al. Somat Cell Mol Genet (1987) 13: 679. doi:10.1007/BF01534488

Abstract

Granulocyte-colony stimulating factor (G-CSF) is a member of colony stimulating factors which regulate the proliferation and differentiation of hematopoietic progenitor cells. A full-length cDNA clone coding human G-CSF was used as a hybridization probe to detect homologous sequence in human-mouse somatic cell hybrids, flow-sorted human chromosomes, and in situ human metaphase chromosomes. The results indicate that the gene encoding human G-CSF is on the q21–q22 region of chromosome 17, which is involved in translocation of t(15;17) (q23;21) in human acutepromyelocytic leukemia.

Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • Naotoshi Kanda
    • 1
  • Shin-ichi Fukushige
    • 2
  • Tomoaki Murotsu
    • 2
  • Michihiro C. Yoshida
    • 3
  • Masayuki Tsuchiya
    • 4
  • Shigetaka Asano
    • 4
  • Yoshito Kaziro
    • 4
  • Shigekazu Nagata
    • 4
  1. 1.Tokyo Women's Medical CollegeTokyoJapan
  2. 2.Institute for Molecular and Cellular BiologyOsaka UniversityOsakaJapan
  3. 3.Chromosome Research UnitHokkaido UniversitySapporoJapan
  4. 4.Institute of Medical ScienceUniversity of TokyoTokyoJapan

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