Human gene coding for granulocyte-colony stimulating factor is assigned to the q21-q22 region of chromosome 17
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- Kanda, N., Fukushige, S., Murotsu, T. et al. Somat Cell Mol Genet (1987) 13: 679. doi:10.1007/BF01534488
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Granulocyte-colony stimulating factor (G-CSF) is a member of colony stimulating factors which regulate the proliferation and differentiation of hematopoietic progenitor cells. A full-length cDNA clone coding human G-CSF was used as a hybridization probe to detect homologous sequence in human-mouse somatic cell hybrids, flow-sorted human chromosomes, and in situ human metaphase chromosomes. The results indicate that the gene encoding human G-CSF is on the q21–q22 region of chromosome 17, which is involved in translocation of t(15;17) (q23;21) in human acutepromyelocytic leukemia.