Human gene coding for granulocyte-colony stimulating factor is assigned to the q21-q22 region of chromosome 17
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Granulocyte-colony stimulating factor (G-CSF) is a member of colony stimulating factors which regulate the proliferation and differentiation of hematopoietic progenitor cells. A full-length cDNA clone coding human G-CSF was used as a hybridization probe to detect homologous sequence in human-mouse somatic cell hybrids, flow-sorted human chromosomes, and in situ human metaphase chromosomes. The results indicate that the gene encoding human G-CSF is on the q21–q22 region of chromosome 17, which is involved in translocation of t(15;17) (q23;21) in human acutepromyelocytic leukemia.
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- 4.Le Beau, M.M., Westbrook, C.A., Diaz, M.O., Larson, R.A., Rowley, J.D., Gasson, J.C., Golde, D.W., and Sherr, C.J. (1986).Science 231:981–987.Google Scholar
- 7.Maniatis, T., Fritsch, E.F., and Sambrook, J. (1982).Molecular Cloning, A Laboratory Manual (Cold Spring Harbor Laboratory, New York).Google Scholar
- 9.Yoshida, M.C., Ikeuchi, T., and Sasaki, M. (1975).Proc. Jpn. Acad. 51:184–187.Google Scholar