Infantile autism: A total population study of reduced optimality in the pre-, peri-, and neonatal period

  • Christopher Gillberg
  • I. Carina Gillberg
Article

Abstract

Twenty-five autistic children, constituting a total population sample of children with infantile autism, were compared with 25 sex- and maternityclinic-matched controls for occurrence of reduced optimality in the pre-, peri-, and neonatal period, as noted in medical records. Autistic children showed greatly increased scores for reduced optimality, especially with regard to prenatal factors. The findings are at odds with early reports that children with autism had not suffered potential brain injury. The reasons for the discrepancy are discussed.

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Reference notes

  1. 1.
    Kyllerman, M. Non-optimal pre- and perinatal conditions in dyskinetic cerebral palsy. Distribution and comparison to controls.Neuropediatrics, 1982, submitted for publication.Google Scholar
  2. 2.
    Kyllerman, M., & Hagberg, G. Non-optimal pre- and perinatal conditions in a Swedish newborn population.Neuropediatrics, 1982, submitted for publication.Google Scholar

References

  1. 3.
    Bradley, J. W.Distribution-free statistical tests, 68–86. Englewood Cliffs, New Jersey: Prentice-Hall, 1968.Google Scholar
  2. 4.
    Broman, S., Nichols, P., & Kennedy, W.Preschool IQ: Prenatal and developmental correlates. Hillsdale, New Jersey: Erlbaum, 1975.Google Scholar
  3. 5.
    Deykin, E., & MacMahon, G. Pregnancy delivery and neonatal complications among autistic children.American Journal of Diseases of Children, 1980,134, 860–864.PubMedGoogle Scholar
  4. 6.
    Finegan, J-A., & Quarrington, B. Pre-, peri- and neonatal factors and infantile autism.Journal of Child Psychology and Psychiatry, 1979,20, 119–128.PubMedGoogle Scholar
  5. 7.
    Folstein, S., & Rutter, M. Infantile autism: A genetic study of 21 twin pairs.Journal of Child Psychology and Psychiatry, 1977,18, 297–321.PubMedGoogle Scholar
  6. 8.
    Gillberg, C. Maternal age and infantile autism.Journal of Autism and Developmental Disorders, 1980,10, 293–297.PubMedGoogle Scholar
  7. 9.
    Gillberg, C. Infantile autism and other childhood psychoses in a Swedish urban region. Epidemiological aspects.Journal of Child Psychology and Psychiatry, 1983, in press.Google Scholar
  8. 10.
    Gillberg, C., & Rasmussen, P. Perceptual, motor and attentional deficits in seven-year-old children. Background factors.Developmental Medicine and Child Neurology, 1982,24, 752–770.PubMedGoogle Scholar
  9. 11.
    Gillberg, C., & Schaumann, H. Social class and infantile autism.Journal of Autism and Developmental Disorders, 1982,12, 223–228.PubMedGoogle Scholar
  10. 12.
    Gillberg, C., Trygstad, O., & Foss, I. Childhood psychosis and urinary excretion of peptides and protein-associated peptide complexes.Journal of Autism and Developmental Disorders, 1982,12, 229–241.PubMedGoogle Scholar
  11. 13.
    Harper, J., & Williams, S. Early environmental stress and infantile autism.Medical Journal of Australia, 1974,61, 341–346.Google Scholar
  12. 14.
    Kanner, L. Autistic disturbances of affective contact.Nervous Child, 1943,2, 217–250.Google Scholar
  13. 15.
    Knobloch, H., & Pasamanick, B. Some etiologic and prognostic factors in early infantile autism and psychosis.Pediatrics, 1975,55, 182–191.PubMedGoogle Scholar
  14. 16.
    Kolvin I., Ounsted, C., & Roth, M. Studies in the childhood psychoses—V. Cerebral dysfunction and childhood psychoses.British Journal of Psychiatry, 1971,118, 407–414.PubMedGoogle Scholar
  15. 17.
    Lobascher, M., Kingerlee, P., & Gubbay, S. Childhood autism: Aetiological factors in 25 cases.British Journal of Psychiatry, 1970,117, 525–529.PubMedGoogle Scholar
  16. 18.
    Michaelis, R., Haug, S., Majewski, F., Bierich, J. R., & Dopfer, R. Obstetrische und postnatale Komplikationen bei Kindern mit einer Alkoholembryopathie.Monatsschrift für Kinderheilkunde, 1980,128, 21–26.Google Scholar
  17. 19.
    Michaelis, R., Rooschüz, B., & Dopfer, R. Prenatal origin of congenital spastic hemiparesis.Early Human Development, 1980,4(3), 243–255.PubMedGoogle Scholar
  18. 20.
    Prechtl, H. F. R. Neurological findings in newborn infants after pre- and paranatal complications. In J. H. P. Jonxis, H. K. A. Visser, & J. A. Troelstra (Eds.),Aspects of prematurity and dysmaturity: A Nutrica Symposium. Leiden: Stenfert Kroesse, 1968. Pp. 306–309.Google Scholar
  19. 21.
    Prechtl, H. F. R. The optimality concept.Early Human Development, 1980,4(3), 201–205.PubMedGoogle Scholar
  20. 22.
    Rutter, M. Diagnosis and definition. In M. Rutter & E. Schopler (Eds.),Autism: A reappraisal of concepts and treatments. New York: Plenum Press, 1978.Google Scholar
  21. 23.
    Rutter, M., & Lockyer, L. A five- to fifteen-year follow-up study of infantile psychosis: I. Description of the sample.British Journal of Psychiatry, 1967,113, 1169–1182.PubMedGoogle Scholar
  22. 24.
    Rutter, M., & Schopler, E. (Eds.).Autism: A reappraisal of concepts and treatment. New York: Plenum Press, 1978.Google Scholar
  23. 25.
    Small, J. G. EEG and neurophysiological studies of early infantile autism.Biological Psychology, 1975,10, 385–397.Google Scholar
  24. 26.
    Student, M., & Sohmer, H. Evidence from auditory nerve and brainstem-evoked responses for an organic brain lesion in children with autistic traits.Journal of Autism and Childhood Schizophrenia, 1978,8, 13–20.PubMedGoogle Scholar
  25. 27.
    Torrey, E. F., Hersh, S. P., & McCabe, K. D. Early childhood psychosis and bleeding during pregnancy: A prospective study of gravid women and their offspring.Journal of Autism and Childhood Schizophrenia, 1975,5, 287–297.PubMedGoogle Scholar
  26. 28.
    Touwen, B. C. L., Huishes, H. J., Jurgens-v.d.Zee, A. D., Bierman-van Eendenburgh, M. E. C., Smrkovsky, M., & Olinga, A. A. Obstetrical condition and neonatal neurological morbidity. An analysis with the help of the optimality concept.Early Human Development, 1980,4(3), 207–228.PubMedGoogle Scholar
  27. 29.
    Wing, L.Early childhood autism (2nd ed.). Oxford: Pergamon Press, 1980.Google Scholar

Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • Christopher Gillberg
    • 1
  • I. Carina Gillberg
    • 1
  1. 1.Barn-och ungdomspsykiatriska klinikenGöteborgs UniversitetGöteborgSweden

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