Immune abnormalities in patients with autism

  • Reed P. Warren
  • Nadine C. Margaretten
  • Nancy C. Pace
  • Ann Foster

Abstract

We have begun an investigation on the immune systems of patients with autism in attempt to determine if immune mechanisms are involved in the development of this severe developmental disorder. A study of 31 autistic patients has revealed several immune-system abnormalities, including reduced responsiveness in the lymphocyte blastogenesis assay to phytohemagglutinin, concanavalin A, and pokeweed mitogen; decreased numbers of T lymphocytes; and an altered ratio of helper to suppressor T cells. Immune-system abnormalities may be directly related to underlying biologic processes of autism, or these changes may be an indirect reflection of the actual pathologic mechanism.

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References

  1. Coffey, C. E., Sullivan, J. L., & Rice, J. R. (1983). T lymphocytes in schizophrenia.Biological Psychiatry, 18, 113–119.PubMedGoogle Scholar
  2. DeLisi, L. E., Goodman, S., Neckers, L. M., & Wyatt, R. J. (1982). An analysis of lymphocyte subpopulations in schizophrenic patients.Biological Psychiatry, 17, 1003–1009.PubMedGoogle Scholar
  3. Nyland, H., Ness, A., & Lunde, H. (1980). Lymphocyte subpopulations in peripheral blood from schizophrenic patients.Acta Psychiatrica Scandinavica, 61, 313–318.PubMedGoogle Scholar
  4. Renoux, G. (1984). Brain neocortex and the immune system.Immunology Today, 5, 218.Google Scholar
  5. Ritvo, E. R., Yuwiler, A., Geller, E., Ornitz, E. M., Saeger, K., & Plotkin, S. (1970). Increased blood serotonin and platelets in early infantile autism.Archives of General Psychiatry, 23, 566–572.PubMedGoogle Scholar
  6. Schleifer, S. J., Keller, S. E., Siris, S. G., Davis, K. L., & Stein, M. (1985). Depression and immunity: Lymphocyte function in ambulatory depressed patients, hospitalized schizophrenic patients and patients hospitalized for herniorrhaphy.Archives of General Psychiatry, 42, 129–133.PubMedGoogle Scholar
  7. Slauson, D. O., Walker, C., Kristensen, F., Wang, Y., & DeWeck, A. L. (1984). Mechanisms of serotonininduced lymphocyte proliferation inhibition.Cellular Immunology, 84, 240–252.PubMedGoogle Scholar
  8. Stubbs, E. G. (1976). Autistic children exhibit undetectable hemagglutination-inhibition antibody titers despite previous rubella vaccination.Journal of Autism and Childhood Schizophrenia, 6, 269–274.PubMedGoogle Scholar
  9. Stubbs, E. G., Crawford, M. L., Burger, D. R., & Vandenbark, A. A. (1977). Depressed lymphocyte responsiveness in autistic children.Journal of Autism and Childhood Schizophrenia, 7, 49–55.PubMedGoogle Scholar
  10. Thomas, Y., Rogozinski, L., Irgoyen, O. H., Friedman, S. H., Kung, P. C., & Schess, L. (1981). Functional analysis of human T cell subsets defined by monoclonal antibodies. IV. Induction of suppressor cells within the OKT4 + population.Journal of Experimental Medicine, 154, 459–467.PubMedGoogle Scholar
  11. Waksman, B. H. (1981). Current trends in multiple sclerosis research.Immunology Today, 2, 87–93.Google Scholar
  12. Warren, R. P., Stembridge, A. M., & Gardner, E. J. (1985). Deficient immune function of peripheral blood mononuclar cells from patients with Gardner syndrome.Clinical and Experimental Immunology, 60, 525–531.PubMedGoogle Scholar
  13. Weizman, A., Weizman, R., Szekely, G. A., Wijsenbeek, H., & Livni, E. (1982). Abnormal immune response to brain tissue antigen in the syndrome of autism.American Journal of Psychiatry, 139, 1462–1465.PubMedGoogle Scholar
  14. Yates, A. (1984). Autism: The case for left hemispheric damage.Arizona Medicine, 16, 395–397.Google Scholar
  15. Zarrabi, M. H., Zucker, S., Miller, F., Derman, R. M., Romano, G. S., Harnett, J. A., & Varma, A. O. (1979). Immunologic and coagulation disorders in chlorpromazine treated patients.Annals of Internal Medicine, 91, 194–199.PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • Reed P. Warren
    • 2
  • Nadine C. Margaretten
    • 2
  • Nancy C. Pace
    • 2
  • Ann Foster
    • 1
  1. 1.Primary Children's Medical CenterSalt Lake City
  2. 2.Utah State UniversityLogan

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