European Archives of Oto-Rhino-Laryngology

, Volume 254, Issue 2, pp 95–100 | Cite as

Neuronal responses to vestibular stimulation in the guinea pig hypothalamic paraventricular nucleus

  • F. Liu
  • A. Inokuchi
  • S. Komiyama
Original Paper
Received:
Accepted:

Abstract

We investigated the effects of caloric stimulation on neuronal activity in the hypothalamic paraventricular nucleus (PVN) in anesthetized guinea pigs. Hot water stimulation of the contralateral labyrinth produced excitation in 29.4% of the PVN neurons tested, while cold water produced excitation in 22.2% of the neurons. Hot water resulted in inhibition of 22.4% of the neurons and cold water inhibition of 24.7% of the neurons. Intracranial vestibular nerve section greatly reduced responsiveness of the PVN neurons to caloric stimulation, indicating that the majority of the responses observed were vestibular in origin. The response pattern of the individual PVN neurons was similar following hot and cold water stimulation and after stimulation of the contralateral and ipsilateral labyrinths. These results suggest that the PVN neurons receive vestibular afferents bilaterally according to the intensity of vestibular stimulation, with the information received probably integrated in the hypothalamus to participate in vestibulo-autonomic reflexes.

Key words

Hypothalamic paraventricular nucleus Caloric stimulation Vestibulo-autonomic reflex Guinea pig 
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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • F. Liu
    • 1
  • A. Inokuchi
    • 1
  • S. Komiyama
    • 1
  1. 1.Department of Otorhinolaryngology, Faculty of MedicineKyushu UniversityFukuokaJapan

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