Klinische Wochenschrift

, Volume 61, Issue 6, pp 277–283 | Cite as

Der Tryptophan-Belastungstest als Funktionsparameter bei Lebererkrankungen

  • M. Rössle
  • R. Herz
  • W. Hiss
  • W. Gerok

Oral tryptophan loading test: A specific and quantitative test of hepatic function


Because of its specific hepatic degradation tryptophan was orally administered (50 mg/kg) to patients with various chronic liver diseases (n=30) and to healthy volunteers (n=8) as a test for hepatic function. The plasma half life of tryptophan was determined between 4 and 8 h after the amino acid load. It was found that in patients with cirrhosis (n=25) the half life of tryptophan was prolonged to 4.7±0.4 h (x±SD), compared to 2.0±0.1 h in the controls. The tryptophan half life also correlated with the plasma concentration of albumin, bilirubin, cholinesterase and prothrombin time in these patients. In addition a significant correlation was observed with the galactose elimination capacity and the 45 min retention of BSP. Thus, the oral tryptophan loading test may be suitable for a more specific determination of functional impairment of the liver in chronic liver disease. In decompensated cirrhotic patients alterations of the tryptophan metabolism seen to be related to indicators of hepatic encephalopathy. The test may therefore be used to assess the degree and risk of hepatic encephalopathy in such patients.

Key words

Tryptophan loading test Liver function 


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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • M. Rössle
    • 1
  • R. Herz
    • 1
  • W. Hiss
    • 1
  • W. Gerok
    • 1
  1. 1.Med. Univ.-KlinikFreiburgBundesrepublik Deutschland

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