The lectin properties of gluten as the basis of the pathomechanism of gluten-sensitive enteropathy
- 32 Downloads
The pathogenesis of gluten-sensitive enteropathy is as yet unknown. According to one theory gluten may act as a lectin with toxic properties for the intestinal cells.
We can now confirm this theory by laser nephelometric measurements and demonstrate the oligomannosyl specificity of this lectin-like protein gluten. Furthermore, we demonstrate the highly more intensive binding capacity of gluten for the glycoproteins of the immature crypt cells of the intestinal brush border compared to those from the mature villous zone. It is discussed that gluten-sensitive enteropathy is caused by a genetically determined defect-glycosylation of intestinal glycoproteins with the synthesis of more mannosylated glycoproteins.
Key wordsLectin Gluten-sensitive enteropathy High-mannose type glycoproteins
- 1.Falchuk ZM, Nelson DL, Katz AJ, Bernardin JE, Kaasarda DD (1980) Gluten-sensitive enteropathy. J Clin Invest 66:227–233Google Scholar
- 2.Frazer AC, Fletcher RF, Ross CAC, Shaw B, Sammons HG, Schneider R (1959) Gluten-induced enteropathy. The effect of partially digested gluten. Lancet 2:252–255Google Scholar
- 3.Köttgen E, Bauer Ch, Gerok W (1979) Laser nephelometry of lectin-glycoprotein complexes: A new method for their quantitation and differentiation. Analyt Biochem 96:391–394Google Scholar
- 4.Köttgen E, Bauer Ch, Ehlerding U, Gerok W (1981) Concanavalin A, a receptor protein with apparently co-operative binding characteristics. Biochem J 193:659–662Google Scholar
- 5.Kornfeld S (1982) Glycoprotein biosynthesis. In: M.I. Horowitz (ed) The glycoconjugates, vol III. Academic Press, New York, pp 3–23Google Scholar
- 7.Schachter H (1978) Glycoprotein biosynthesis. In: Horowitz MI, Pigman W (eds) The glycoconjugates, vol II. Academic Press, New York, pp 87–181Google Scholar
- 8.Sharon N, Lis H (1973) The biochemistry of plant lectins. Ann Rev Biochem 42:541–575Google Scholar
- 10.Weiser MM (1973) Intestinal epithelial cell surface membrane glycoprotein synthesis, an indicator of cellular differentiation. J Biol Chem 248:2536–2541Google Scholar
- 11.Weiser MM, Douglas AP (1976) An alternative mechanism for gluten toxicity in coeliac disease. Lancet 2:567–569Google Scholar