Klinische Wochenschrift

, Volume 53, Issue 9, pp 403–417 | Cite as

Carcinofetale Antigene

III. Andere carcinofetale Antigene
  • R. Lamerz
  • A. Fateh-Moghadam
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Zusammenfassung

Es wird über Vorkommen und Bedeutung der wichtigsten anderen carcinofetalen Antigene außer AFP und CEA berichtet. Dazu zählen das Alpha-2-H-Protein, das in der Leber gebildet wird und bei verschiedenen Tumoren im Serum vermehrt auftritt; das fetale Sulphoglykoprotein-Antigen (FSA) aus dem Magensaft von Magenkrebskranken; die carcinoplacentale alkalische Phosphatase im Serum (REGAN-Isoenzym), die sich u.a. bei Bronchial-, Mamma-, Urogenital- und Gastrointestinal-Carcinomen nachweisen läßt; das wahrscheinlich mit CRP identische Beta-S-Fetoprotein; Gamma-Fetoprotein; das carcinofetale Glia-Antigen (CFGA) aus Gliablastomen und Astrocytomen; ektope Placenta-Hormonbildung (Gonadotropin, HPL, Plasminogen-Aktivatoren); leukämie-assoziierte Antigene. Ferner wird auf weitere weniger bekannte carcinofetale Antigene hingewiesen.

Schlüsselwörter

Tumorimmunologie carcinofetale Antigene Alpha 2 H-Protein fetales Sulphoglykoprotein Antigen FSA REGAN-Isoenzym carcinofetales Glia-Antigen (CFGA) 

Carcinofetal antigens. III. Further carcinofetal antigens

Summary

The occurrence and significance of important carcinofetal antigens other than AFP and CEA are reported. These include the alpha 2 H-protein which is produced in the liver and increases in serum of patients with various tumors, the fetal sulphoglycoprotein antigen FSA from the gastric juice of patients with gastric cancer, the carcinoplacental alkaline phosphatase (REGAN-isoenzyme) which is found in the serum of patients suffering from e.g. bronchogenic, mammary, urogenital and gastrointestinal carcinomas, the beta-S-fetoprotein which is most likely to be identical with C-reactive protein, gamma-fetoprotein, the carcinofetal antigen in glial tumors (CFGA); ectopic production of placental hormones like human gonadotropin, placental lactogen, plasminogen-activators; leukemia-associated antigens. Furthermore, some other less known carcinofetal antigens are mentioned.

Key words

Tumor immunology carcinofetal antigens alpha 2-H protein fetal sulphoglycoprotein antigen FSA REGAN-isoenzyme) carcinofetal glial antigen (CFGA) 

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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • R. Lamerz
    • 1
  • A. Fateh-Moghadam
    • 1
  1. 1.I. Medizinische Klinik der Universität MünchenGermany

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