Klinische Wochenschrift

, Volume 61, Issue 14, pp 715–717 | Cite as

Effect of dehydroepiandrosterone on hereditary angioedema

  • E. Koó
  • K. G. Fehér
  • T. Fehér
  • G. Füst
Originalien

Summary

Hereditary angioneurotic edema (HAE) is a complement-related clinical disorder with a deficiency of the C1 esterase inhibitor protein. Eight patients with severe attacks of the disease were treated with the adrenal “androgen” dehydroepiandrosterone sulphate (DS). Steroid therapy for 3–28 months resulted in dramatic improvement in their clinical state and a moderate increase in the serum concentration of C1 inhibitor. There was a significant increase in the serum level of either unconjugated dehydroepiandrosterone (D) or of DS during treatment.

Key words

Hereditary angioedema C1 esterase inhibitor deficiency Dehydroepiandrosterone therapy 

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Copyright information

© Springer-Verlag GmbH & Co KG 1983

Authors and Affiliations

  • E. Koó
    • 1
  • K. G. Fehér
    • 1
  • T. Fehér
    • 2
  • G. Füst
    • 3
  1. 1.Natl. Inst. of Rheumatology and PhysiotherapyBudapest 114Hungary
  2. 2.First Department of MedicineSemmelweis University Medical SchoolBudapest
  3. 3.National Institute of Hematology and Blood TransfusionBudapest

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