Klinische Wochenschrift

, Volume 55, Issue 6, pp 247–258 | Cite as

Kinetik und Regulation der Granulopoese

  • P. Forrer
Übersichten

Zusammenfassung

Die vorliegende Übersicht über die Granulocytenentwicklung gliedert sich in zwei Teile. Im ersten werden die einzelnen Stufen der Granulopoese unter besonderer Berücksichtigung des Stammzellproblems besprochen.

Der zweite Teil, die Regulation der Granulopoese, untersucht die einzelnen Faktoren, die an der peripheren Granulocytenhomeostase beteiligt sind. Im Vordergrund steht hier die „colony stimulating activity“ (CSA), die schon in den verschiedensten Streßsituationen des granulopoetischen Systems getestet wurde.

In einem besonderen Kapitel werden einige markante klinische Syndrome, die mit einer Störung der Granulocytenhomeostase einhergehen, im Rahmen der Granulocytenkinetik untersucht. Bei dieser Gelegenheit wird die Pathogenese der Leukämie eingehend diskutiert.

Schlüsselwörter

Granulocyten Kinetik Regulation Funktion Kulturen in vitro Neutropenie Granulocytose 

Kinetics and regulation of granulocytopoiesis

Summary

The present survey of the development of the granulocytes consists of two parts. In the first section the different stages of granulopoiesis are discussed with special regard to the stem cells.

In the second one the regulation of the granulopoiesis and the different factors taking part in the homeostasis of the granulocytes are examined. Emphasis is placed upon the “colony stimulating activity” (CSA) previously tested in different situations of stress in relationship to the granulopoietic system.

In a separate chapter some marked clinical syndromes are discussed which accompany disorders of granulocyte-homeostasis. The pathogenesis of leukaemia is reviewed.

Key words

Granulocytes Kinetics Regulation Function Cultures in vitro Neutropenic disorders Granulocytosis 

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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • P. Forrer
    • 1
  1. 1.Medizinische Klinik des Stadtspitals Waid ZürichSwitzerland

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