Klinische Wochenschrift

, Volume 39, Issue 4, pp 165–173 | Cite as

Fragen der Blutgerinnung bei extrakorporalem Kreislauf mit der Herz-Lungen-Maschine

  • R. Gross
  • R. Holemans
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Literatur

  1. 1.
    Allen, J. G., P. V. Moulder, R. E. Elghammer, B. J. Grossmann, G. L. McKen, M. H. Sanderson, W. Egner andJ. M. Crosbie: Protamine titration as an indication of a clotting defect in certain hemorrhagic states. J. Lab. clin. Med.43, 473 (1949).Google Scholar
  2. 1a.
    Alagille, D., R. Heim de Balsac, J. Guéry, J. Passelecq, P. Blondeau etCh. Dubot: Les thrombopathias associees aux cardiopathies congénitales. Rev. franç. clin. biol.3, 322 (1958).Google Scholar
  3. 2.
    Amery, T.: Hemostasestoornissen van algemene oorsprong in de verloskundige praktijk. Belg. T. Geneesk.15, 853 (1959).Google Scholar
  4. 3.
    Astrup, T.: Fibrinolysis. Acta haemat. (Basel)7, 271 (1952).Google Scholar
  5. 4.
    Beer, R., u.G. Loeschcke: Probleme bei Operationen mit extrakorporalem Kreislauf unter besonderer Berücksichtigung der Anaesthesie. Anaesthesist8, 70 (1959).Google Scholar
  6. 5.
    Beller, F. K.: Zur Frage des Blut- bzw. Flüssigkeitsersatzes sowie der Fibrinogeninfusion bei Gerinnungsstörungen als geburtshilfliche Komplikation. Ergebn. Bluttransfusionsforsch.3, 140 (1957).Google Scholar
  7. 6.
    Binder, L. S., V. Ginsberg andM. H. Harmel: Incompatible blood transfusions during operation. Brit. J. Anaesth.31, 217 (1959).Google Scholar
  8. 7.
    Blombäck, B., M. Blombäck, P. Olsson, G. William-Olsson andA. Senning: Determination of heparin level of the blood. Acta chir. scand. Suppl.254, 259 (1959).Google Scholar
  9. 8.
    Bounameaux, Y.: L'Accollement des plaquettes à une surface étrangère. Thromb. diat. haemorrhag.1, 209 (1957).Google Scholar
  10. 9.
    Brom, A. G., andJ. Nauta: First experiences in the clinical use of extracorporeal circulation. Thorax13, 277 (1958).Google Scholar
  11. 10.
    Brown, I. W., andW. W. Smith: Hematologic problems associated with the use of extracorporeal circulation for cardiovascular surgery. Ann. intern. Med.49, 1035 (1958).Google Scholar
  12. 11.
    Bücherl, E. S., G. Horkenbach u.K. J. Schmutzer: Probleme des Säure-Basenhaushaltes während extrakorporaler Zirkulation. Thoraxchirurgie6, 505 (1959).Google Scholar
  13. 12.
    Buluk, K., u.T. Januszko: Heparyna a fibrynoliza. Pat. Pol.8, 107 (1957).Google Scholar
  14. 13.
    Bunker, J. P., J. B. Stetson, R. C. Coe, H. C. Grillo andA. J. Murphy: Citric acid intoxication. J. Amer. med. Ass.157, 1361 (1955).Google Scholar
  15. 13a.
    Cho, M., andL. B. Jaques: Heparinase. Preparation and properties of the enzyme. Canad. J. Biochem.34, 799 (1956).Google Scholar
  16. 14.
    Clauss, A.: Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens. Acta haemat. (Basel)17, 237 (1957).Google Scholar
  17. 15.
    Cleland, W. P., A. J. W. Beard, H. H. Bentall, M. B. Bishop, M. V. Brainmbridge, L. L. Bromberg, J. F. Goodwin, A. Hollman, W. F. Kerr, E. B. Lloyd-Jones, D. G. Melrose andL. J. Telivro: The treatment of ventricular septal defect. Brit. med. J.1958 I, 1369.Google Scholar
  18. 16.
    Clowes, G. H. A., W. E. Neville, A. Hopkins, J. Anzola andF. A. Simeone: Factors contributing to success or failure in the use of a pump oxygenator for complete cardiac by-pass of the heart and lung. Surg.36, 557 (1954).Google Scholar
  19. 17.
    Conley, C. L., C. R. Hartmann andJ. S. Lalley: Relation of heparin activity to platelet concentration. Proc. Soc. exp. Biol. (N.Y.)69, 28 (1948).Google Scholar
  20. 18.
    Cooley, D. A., B. A. Belmonte, M. E. de Bakey andJ. R. Latson: Temporary extracorporeal circulation in the surgical treatment of cardiac and aortic disease. Ann. Surg.145, 898 (1957).Google Scholar
  21. 19.
    Crafoord, C.: Some aspects of the development of intrathoracic surgery. Surg. Gynec. Obstet.89, 629 (1949).Google Scholar
  22. 20.
    Crafoord, C., B. Norberg andA. Senning: Clinical studies in extra-corporeal circulation with a heart-lung-machine. Acta chir. scand.112, 220 (1957).Google Scholar
  23. 21.
    Crafoord, C.: Operationen am offenen Herzen mit Herz-Lungen-Maschine. Langenbecks Arch. klin. Chir.289, 257 (1958).Google Scholar
  24. 22.
    Dahlbäck, O., L. T. Delaney, L. E. Gelin, J. Kugelberg, E. Linder andS. E. H. Nilsson: A plasma substitute in extra-corporeal circulation: an attempt to minimize the damage to the blood. A preliminary experimental report. Acta chir. scand. Suppl.245, 265 (1959).Google Scholar
  25. 23.
    Geeter, L. de, etA. Dumont: La fibrinolyse et les modifications de quelques facteurs de la coagulation au cours des interventions de chirurgie thoracique. Acta med. Belg.3, 324 (1955).Google Scholar
  26. 24.
    Desmet, V., M. Verstraete etJ. Vandenbroucke: Propriétés coagulantes d'hémolysats erythrocytaires. Thromb. diath. haemorrhag.1, 459 (1957).Google Scholar
  27. 25.
    Deutsch, E.: Die Blutgerinnung. InNaegeli, Matis, Gross, Runge, Sachs: Handbuch der thromboembolischen Erkrankungen. Stuttgart: Schattauer 1960.Google Scholar
  28. 26.
    Deutsch, E.: Blutgerinnungsfaktoren. Wien: Deuticke 1955.Google Scholar
  29. 27.
    Deutsch, E., E. Wawersich u.G. Franke: Über das Vorkommen eines Antiheparinfaktors in Thrombocyten und Geweben. Thromb. diath. haemorrhag.1, 397 (1957).Google Scholar
  30. 28.
    Didisheim, P., K. Hattori andJ. Lewis: Hematologic and coagulation studies in various animal species. J. Lab. clin. Med.53, 866 (1959).Google Scholar
  31. 29.
    Wall, R. A. de, H. E. Wander andC. W. Lillehei: The helix reservoir bubble oxygenator and its clinical application in extracorporeal circulation, p. 41. edit.J. C. Alle. Springfield, Ill.: Thomas 1958.Google Scholar
  32. 30.
    Dittrich, H., E. Puffer u.E. Seifert: Klinische Untersuchungen über die Hitzefibrinbestimmung nachSchulz. Medizinische25, 1202 (1959).Google Scholar
  33. 31.
    Dodrill, F. D., E. Hill andR. Gerisch: Some physiologic aspects of the artificial heart problem. J. thorac. Surg.24, 134 (1952).Google Scholar
  34. 32.
    Dodrill, F. D., N. Marshall, J. Nyboer, C. H. Hughes, A. J. Derbyshire andA. B. Stearns: The use of the heart-lung apparatus in human cardiac surgery. J. thorac. Surg.33, 60 (1957).Google Scholar
  35. 33.
    Donald, D. E., G. Harshbarger, P. S. Hetzel, R. T. Patrick, E. H. Wood, andJ. W. Kirklin: Experiences with a heart-lung-bypass (Gibbon type) in the experimental laboratory. Proc. Mayo Clin.30, 113 (1955).Google Scholar
  36. 34.
    Eerland, L. D.: Intrakardialer Verschluß isolierter Ventrikelseptumdefekte mit Hilfe einer Herz-Lungen-Maschine. Thoraxchirurgie6, 277 (1959).Google Scholar
  37. 35.
    Effler, D. B., W. J. Kolff, L. K. Groves andF. M. Jones: Disposable membrane oxygenator (heart-lung-machine) and its use in experimental surgery. J. thorac. Surg.32, 620 (1956).Google Scholar
  38. 35a.
    Egli, H., u.K. Kessler: Über die Anwendung der Plasmafraktion I bei unstillbaren Blutungen. Dtsch. med. Wschr.81, 875 (1956).Google Scholar
  39. 36.
    Fantl, P., andB. A. Everard: The action of protamine on blood plasma. Aust. J. exp. Biol. med. Sci.28, 253 (1950).Google Scholar
  40. 36a.
    Favre-Cilly, J.: Les difficultés d'estimation du faux de la prothrombine chez les polyglobuliques. Sang27, 788 (1955).Google Scholar
  41. 36b.
    Frick, P. G.: Pseudohyperkaliämie bei Thrombocytose. Schweiz. med. Wschr.90, 433 (1960).Google Scholar
  42. 37.
    Friesen, S. R., W. Harsha andC. H. McCroskey: Massive generalized wound bleeding during operation with clinical and experimental evidence of blood transfusion reactions. Surgery32, 620 (1952).Google Scholar
  43. 37a.
    Gerock, W.: Eine Methode zur Mikrobestimmung der Fibrinogenkonzentration im Blutplasma. Klin. Wschr.31, 135 (1953).Google Scholar
  44. 38.
    Geszti, O., Ts'ao Wei-chi andLi Thien-Huang: Experimental data about heparin neutralizing effect of intravenous administered calcium. Acta physiol. Acad. Sci. hung.13, 341 (1958).Google Scholar
  45. 39.
    Giacomazzi, G.: Influence de l'Heparine sur la fibrinolyse activée par la streptokinase. Sang29, 614 (1958).Google Scholar
  46. 40.
    Gianelli, S., M. Molthan, R. Best, J. Dull andC. K. Kirly: The effect produced by various types of pump oxygenators during two-hour partial perfusion in dogs. J. thorac. Surg.34, 563 (1957).Google Scholar
  47. 41.
    Gibbon, J. H.: Maintenance of cardiorespiratory functions by extracorporeal circulation. Circulation19, 646 (1959).Google Scholar
  48. 42.
    Gibbon, J. H., B. J. Miller, A. R. Bobell, H. C. Engell andG. B. Voigt: The closure of intraventricular septal defects in dogs during open cardiotomy with maintenance of the cardiorespiratory functions by a pump-oxygenator. J. thorac. Surg.28, 235 (1954).Google Scholar
  49. 43.
    Gross, R.: Hämorrhagische Diathesen. Klin. Gegenw.9, 161 (1959).Google Scholar
  50. 43a.
    Gross, R.: Pathogenese und Klinik der Thrombocytopathien. Verh. dtsch. Ges. inn. Med.66 (1960).Google Scholar
  51. 44.
    Gross, R.: Unveröffentlichte Untersuchungen 1957.Google Scholar
  52. 45.
    Gross, R., J. Heuer u.K. Solth: Quantitative Beziehungen zwischen Heparin und Thrombocyten. Acta haemat. (Basel)16, 147 (1956).Google Scholar
  53. 45a.
    Gross, R., u.E. Staufenberg: Über den Einfluß von 5-Hydroxytryptamin (Serotonin), 5-Hydroxytryptophan und Serotoninantagonisten auf die Retraktion von Blutgerinnseln. Thromb. diath. haemorrhag.2, 125 (1958).Google Scholar
  54. 46.
    Gross, R. E.: Open-heart surgery for repair of congenital defects. New Engl. J. Med.260, 1047 (1959).Google Scholar
  55. 47.
    Guastavino, G. N., J. A. Wikinski u.R. H. André: Untersuchungen über Physiologie und Physiopathologie des extrakorporalen Kreislaufs mit künstlichem Herzen und Lunge. Sem. méd. (B.Aires)66, 521 (1959).Google Scholar
  56. 48.
    Hässig, A.: Vollblut, Plasma und Plasmafraktionen. Ther. Umsch.17, 39 (1960).Google Scholar
  57. 49.
    Halse, Th.: Das fibrinolytische Potential. Medizinische50/51, 1 (1958).Google Scholar
  58. 50.
    Hardawey, R. M., andD. G. McKay: Production of lower nephron nephrosis in dogs by means of an episode of intravascular clotting. Surg. Forum9, 134 (1958).Google Scholar
  59. 51.
    Hardaway, R. M., andD. G. McKay: Production of acute hemorrhagic pancreatitis in dogs by means of an episode of intravascular clotting in the pancreas. Surgery45, 557 (1959).Google Scholar
  60. 52.
    Hardaway, R. M., andD. G. McKay: Disseminated intravascular coagulation: a cause of shock. Ann. Surg.149, 462 (1959).Google Scholar
  61. 53.
    Harders, H.: Zur diätetisch induzierten und postoperativen Thromboseneigung. Thromb. diath. haemorrhag.1, 482 (1957).Google Scholar
  62. 54.
    Hardisty, R. M., andJ. Margolis: The role of Hageman factor in the initiation of blood coagulation. Brit. J. Haemat.5, 203 (1959).Google Scholar
  63. 55.
    Hartert, H.: Thrombelastographische Untersuchungen zur Fibrinolyse. Klin. Wschr.28, 78 (1950).Google Scholar
  64. 56.
    Helmsworth, J. A., L. C. Clark, S. Kaplan, R. T. Sherman andT. Langer: Artificial oxygenation and circulation during complete bypass of the heart. J. thorac. Surg.24, 117 (1952).Google Scholar
  65. 57.
    Hidalgo, J., A. F. Fowell andR. J. Ralls: Effect of tissue damage on the plasma fibrinogen level. Surg. Gynec. Obstet.95, 661 (1952).Google Scholar
  66. 58.
    Holemans, R.: Proefondervindelijke studie von de invloed van enkele anticoagulantia van het heparinoide type op de bloed-stolling. Proefschrift Wedstr. Reisbeurzen Belg. Staat, 1957.Google Scholar
  67. 59.
    Holemans, R., A. Amery andM. Verstraete: Clotting deviations during complete cardiac by-pass in dogs with a heart-lung-apparatus Crafoord-Senning. Cardiologia (Basel)37, 193 (1960).Google Scholar
  68. 60.
    Holemans, R., C. Vermylen etM. Verstraete: Etudes experimentales des quelques problemes de la coagulation sangiune en rapport avec la circulation extracorporale. Méd. exp.2, 294 (1960).Google Scholar
  69. 61.
    Hougie, C., M. E. Garrard, W. D. Warren, F. Damman andW. H. Muller: Coagulation problems relating to the use of the extracorporeal circulation in man. Proc. 7th Congr. Intern. Soc. Blood Transf., Rome 1958, p. 28. Basel: S. Karger.Google Scholar
  70. 62.
    Howland, W. S.: Cardiovascular and clotting disturbances during massive blood replacement. Anesthesiology19, 140 (1958).Google Scholar
  71. 63.
    Ibring, G.: Extracorporeal circulation and postoperative erythrocyte destruction. Acta chir. scand.116, 79 (1959).Google Scholar
  72. 64.
    Isliker: Diskussion zuWinterstein in „Heparin“, vorgetragen auf der 8. Tagg der Dtsch. Ges. Bluttransfusion, Salzburg, Sept. 1959.Google Scholar
  73. 65.
    Jaques, L. B.: Heparinase. J. biol. Chem.133, 445 (1940).Google Scholar
  74. 66.
    Jaques, L. B.: The reaction of heparin with proteins and complex bases. Biochem. J.37, 189 (1949).Google Scholar
  75. 67.
    Jaques, L. B.: A study of the toxicity of the protamine, salmine. Brit. J. Pharmacol.4, 135 (1949).Google Scholar
  76. 68.
    Jaques, L. B., u.F. C. Monkhouse: Zit. nachWinterstein in „Heparin“, vorgetragen auf der 8. Tagg der Dtsch. Ges. Bluttransfusion, Salzburg, Sept. 1959.Google Scholar
  77. 69.
    Johnson, S. A., andC. L. Schneider: The existence of antifibrinolysin acitivity in platelets. Science117, 229 (1953).Google Scholar
  78. 70.
    Jones, D. E., E. E. Donald, J. H. Swan, H. C. Harshbarger, J. W. Kirklin andE. H. Wood: Apparatus of the Gibbon type for mechanical bypass of the heart and lung. Preliminary report. Proc. Mayo Clin.30, 105 (1955).Google Scholar
  79. 71.
    Jürgens, J., u.F. K. Beller: Klinische Methoden der Blutgerinnungsanlayse. Stuttgart: Georg Thieme 1959.Google Scholar
  80. 72.
    Kaulla, K. N. v., etR. della Santa: Fibrinolyse thérapeutique sans choc. C.R. 3ieme Congr. Soc. Intern. Europ. Hématol. Rome 1951. Ediz. Med. Scientif. Rome 1952, p. 778.Google Scholar
  81. 73.
    Kaulla, K. N. v.: Sang22, 720 (1951).Google Scholar
  82. 74.
    Kaulla, K. N. v., u.W. Henkel: Heparinadsorption durch Erythrocyten. Schweiz. med. Wschr.82, 1128 (1952).Google Scholar
  83. 75.
    Kaulla, K. N. v., B. S. McDonald andC. Taylor: The effect of heparin on fibrinolysis. J. Lab. clin. Med.48, 952 (1956).Google Scholar
  84. 76.
    Kaulla, K. N. v., andR. L. Schultz: Methods for evaluation of human fibrinolysis. Studies with two combined technics. Amer. J. clin. Path.29, 104 (1958).Google Scholar
  85. 77.
    Kaulla, K. N. v., andH. Swan: Clotting deviations in man during cardiac bypass: Fibrinolysis and circulating anticoagulant. J. thorac. Surg.36, 519 (1958).Google Scholar
  86. 78.
    Kay, J. H., andR. A. Gaertner: A simplified pump-oxygenator with flow equal to normal cardiac output. Surg. Forum7, 267 (1957).Google Scholar
  87. 79.
    Keats, A. S., D. A. Cooley andJ. Telford: Relative antiheparin potency of polyprene and protamine in patients undergoing extracorporeal circulation. J. thorac. Surg.38, 362 (1959).Google Scholar
  88. 80.
    Keller, R.: Antagonismus zwischen Heparin und 5-hydroxytryptamin (Serotonin) in vitro. Experientia (Basel)13, 112 (1957).Google Scholar
  89. 81.
    Kirklin, J. W., D. E. Donald, H. G. Harshbarger, P. S. Hetzel, R. T. Patrick, H. J. C. Swan andE. H. Wood: Studies in extracorporeal circulation. I. Applicability of Gibbon-type pump oxygenator to human intracardiac surgery. Ann. Surg.144, 2 (1956).Google Scholar
  90. 81a.
    Koller, F.: Fibrinolyse. Schweiz. med. Wschr.90, 1233 (1960).Google Scholar
  91. 82.
    Kowalski, E., M. Kopec andS. Niewiarowski: An evaluation of the euglobulin method for the determination of fibrinolysis. J. clin. Path.12, 215 (1959).Google Scholar
  92. 83.
    Krevans, J. R., andD. P. Jackson: Hemorrhagic disorder following massive whole blood transfusion. J. Amer. med. Ass.159, 171 (1955).Google Scholar
  93. 84.
    Lee, R. I., andP. D. White: A clinical study of the coagulation time of blood. Amer. J. med. Sci.145, 495 (1913).Google Scholar
  94. 85.
    Levowitz, B. S., M. M. Newman, J. K. Stuckey, M. C. Kernan, H. N. Iticovici andC. Dennis: A mechanical pump-oxygenator for direct vision repair of atrial septal defects. J. thorac. Surg.32, 647 (1956).Google Scholar
  95. 86.
    Lincoln, A., J. A. Moorman andR. Schultz: Fibrinolysis following thoracic surgery. Surg. Gynec. Obstet.150, 541 (1957).Google Scholar
  96. 87.
    Löhr, B.: Über Pumpen, Schläuche und Kanülen in heute gebräuchlichen Herz-Lungen-Maschinen. Thoraxchirurgie6, 302 (1959).Google Scholar
  97. 87a.
    Löhr, B.: Persönliche Mitteilung.Google Scholar
  98. 88.
    Loeliger, A.: Persönliche Mitteilung 1959.Google Scholar
  99. 89.
    Ludbrook, J., andV. Wynn: Citrate intoxication: A clinical and experimental study. Brit. med. J.1958 II, 523.Google Scholar
  100. 90.
    MacFarlane, R. G., andR. Biggs: Observations on fibrinolysis: spontaneous activity associated with surgical operations, trauma etc. Lancet1946 II, 862.Google Scholar
  101. 91.
    Marbet, R., A. Studer u.A. Winterstein: Wirkung von Protamin auf die Blutgerinnung, Thrombose und Embolie. 1. Internat. Tagg., Basel 1954, S. 362.Google Scholar
  102. 92.
    Marbet, R., u.A. Winterstein: Probleme der Blutgerinnung. 3. Mitt. Helv. physiol. pharmacol. Acta9, 24 (1951).Google Scholar
  103. 92a.
    Marx, R., P. Clemente, E. Werle u.W. Appel: Zum Problem eines Antidotes in der internen Thrombotherapie mit Fibrinolytica. Blut5, 367 (1959).Google Scholar
  104. 93.
    Matis, P., u.U. Knorr: InNaegeli, Matis, Gross, Runge u.Sachs, Die thromboembolischen Erkrankungen und ihre Behandlung, S. 126. Stuttgart: Schattauer 1955.Google Scholar
  105. 94.
    McKay, D. G., R. M. Hardaway, G. H. Wahle jr.,R. Edelstein andD. E. Tartock: Alterations in blood coagulation mechanism after incompatible blood transfusion. Amer. J. Surg.89, 583 (1955).Google Scholar
  106. 95.
    Melrose, D. G., andI. Aird: A mechanical heart-lung for use in man. Brit. med. J.1953 II, 57.Google Scholar
  107. 96.
    Melrose, D. G., J. W. Bassett, P. Beaconsfield, I. G. Graber andR. Shackman: Experimental physiology of a heart-lung machine in parallel with normal circulation. Brit. med. J.1953 II, 62.Google Scholar
  108. 97.
    Miller, B. J., J. H. Gibbon andC. Fineberg: An improved mechanical heart and lung apparatus. Med. Clin. N. Amer.37, 1603 (1953).Google Scholar
  109. 98.
    Mills, C. A.: Action of tissue extracts in coagulation of blood. J. biol. Chem.46, 167 (1921).Google Scholar
  110. 99.
    Monkhouse, F. C., R. L. MacMillan andK. W. G. Brown: The relation between heparin blood levels and blood coagulation times. J. Lab. clin. Med.42, 92 (1953).Google Scholar
  111. 100.
    Moore, J. M.: Uncontrollable post-operative haemorrhage after incompatible blood transfusion. Brit. med. J.1958 II, 1201.Google Scholar
  112. 101.
    Mondini, P., eP. Ciliotto: Sulla emorragia a nappo dopo ossigenazione e circulazione extracorporea. Minerva chir. (Torino)12, 163 (1958).Google Scholar
  113. 102.
    Mustard, W. T., andA. L. Chute: Experimental intracardiac surgery with extracorporal circulation. Surgery30, 684 (1951).Google Scholar
  114. 103.
    Mylon, E., M. C. Winternitz andG. J. de Suto-Nagy: The determination of fibrinogen with protamine. J. biol. Chem.143, 21 (1942).Google Scholar
  115. 103a.
    Nicola, P. de: Thrombelastography. Springfield: Thomas 1957.Google Scholar
  116. 104.
    Nieth, H., E. Mammen u.R. Gross: Zur Heparinisierung des Blutes bei der extrakorporalen Hämodialyse. Klin. Wschr.36, 372 (1958).Google Scholar
  117. 105.
    Niewiarowski, S., andE. Kowalski: Antithrombin formation during proteolysis of fibringen. Trans. 6th Congr. Europ. Soc. Haematol. Copenhagen 1957, p. 560.Google Scholar
  118. 106.
    Nilsson, I. M., andJ. Svedberg: Coagulation studies in cardiac surgery with extracorporeal circulation using a bubble-oxygenator. Acta chir. scand.117, 47 (1959).Google Scholar
  119. 107.
    Nixon, P. G. F.: A pump for use in open heart surgery Lancet1959 I, 1074.Google Scholar
  120. 108.
    Nolf, P.: Antithrombine et héparine. Arch. Physiol.58, 441 (1951).Google Scholar
  121. 109.
    Norlander, O.: Anaesthesiologische Erfahrungen aus der intrakardialen Chirurgie mit der Crafoord-Senning-Herz-Lungen-Maschine. Thoraxchirurgie7, 149 (1959).Google Scholar
  122. 110.
    Osborn, J. J., F. Gerbode, H. Perkins, M. Brainbridge, D. Melrose andP. Kahn: A disposable filming pump-oxygenator. J. thorac. Surg.37, 472 (1959).Google Scholar
  123. 111.
    Osborn, J. J., R. MacKenzie, A. Shaw, H. Perkins, R. Hurt andF. Gerbode: Cause and prevention of hemorrhage following extracorporeal circulation. Surg. Forum6, 96 (1955).Google Scholar
  124. 112.
    Owren, P. A., andK. Aas: The control of dicoumarol therapy and the quantitative determination of prothrombin. Scand. J. clin. Lab. Invest.3, 201 (1951).Google Scholar
  125. 113.
    Parfentjev, I. A., M. L. Johnson andE. E. Cliffton: The determination of plasma fibrinogen by turbidity with ammonium sulphate. Arch. Biochem. Biophys.46, 470 (1953).Google Scholar
  126. 113a.
    Peden, J. L., andJ. A. McFarland: Use of plasma thrombin time to assess the adequacy of in vitro neutralization of heparin: comparative studies following operations employing extracorporal circulation. Blood15, 1230 (1959).Google Scholar
  127. 114.
    Penick, G. D., H. E. Averette, R. M. Peters andK. M. Brinkhous: The hemorrhagic syndrome complicating extracorporeal shunting of blood: an experimental study of its pathogenesis. Thromb. diath. haemorrhag.2, 218 (1958).Google Scholar
  128. 115.
    Penick, G. D., H. R. Roberts, W. P. Webster andK. M. Brinkhous: Hemorrhagic states secondary to intravascular clotting. A.M.A. Arch. Path.66, 708 (1958).Google Scholar
  129. 116.
    Perkins, H. A., J. J. Osborn andF. Gerbode: Problems in coagulation, extracorporeal circulation. edit.J. G. Allen. Springfield: Thomas 1958.Google Scholar
  130. 117.
    Perkins, H. A., J. J. Osborn andF. Gerbode: The management of abnormal bleeding following extracorporcal circulation. Ann. intern. Med.51, 658 (1959).Google Scholar
  131. 118.
    Perkins, H. A., J. J. Osborn, R. Hurt andF. Gerbode: Neutralisation of heparin in vivo with protamine. A simple method of estimating the required dose. J. Lab. clin. Med.48, 233 (1956).Google Scholar
  132. 119.
    Perlick, E.: Antikoagulantien. Leipzig: Georg Thieme 1960.Google Scholar
  133. 120.
    Phillips, L. L., P. T. Romley andD. V. Habif: Hypofibrinogenemia in surgical patients. Surg. Gynec. Obstet.103, 443 (1956).Google Scholar
  134. 121.
    Phillips, L. L.: Afibrinogenemia in obstetrical and surgical patients. Bull. Sloane Hosp. Women.2, 1 (1956).Google Scholar
  135. 122.
    Portmann, A. F., andW. D. Holden: Protamine (Salmine) sulphate, heparin and blood coagulation. J. clin. Invest.28, 1451 (1949).Google Scholar
  136. 123.
    Poth, E. J., P. Cunningham andJ. V. Meyer: A critical analysis of the problem of extracorporeal oxygenation of the blood. Amer. Surg.23, 1056 (1957).Google Scholar
  137. 124.
    Quick, A. J.: On the factors underlying intravascular clotting. Surg. Clin. N. Amer.38, 1013 (1958).Google Scholar
  138. 125.
    Quick, A. J., J. G. Georgatos andC. V. Hussey: The clotting activities of human erythrocytes: theoretical and clinical applications. Amer. J. med. Sci.228, 207 (1954).Google Scholar
  139. 126.
    Ratnof, O. D., andJ. M. Rosenbaum: Role of Hageman factor in the initiation of clotting by glass. Amer. J. Med.25, 160 (1958).Google Scholar
  140. 127.
    Ratnof, O. D., andG. J. Vosburgh: Observation on the clotting defect in amniotic fluid embolism. New Engl. J. Med.247, 970 (1952).Google Scholar
  141. 128.
    Reid, D. E.: Clinical considerations in hypofibrinogenemia. Ann. N.Y. Acad. Sci.75, 685 (1959).Google Scholar
  142. 129.
    Reid, E. D., A. E. Weiner andC. C. Roby: Intravascular clotting and afibrinogenemia. The presumptive lethal factors in the syndrome of amniotic fluid embolism. Amer. J. Obstet. Gynec.66, 465 (1953).Google Scholar
  143. 130.
    Reid, D. E., A. E. Weiner, D. D. Roby andL. K. Diamond: Maternal afibrinogenemia associated with long-standing intrauterine fetal death. Amer. J. Obstet. Gynec.66, 500 (1953).Google Scholar
  144. 131.
    Reinert, M., andA. Winterstein: Contribution to the study of heparin. Arch. int. Pharmacodyn.57, 47 (1939).Google Scholar
  145. 132.
    Rothnie, N. G., andJ. B. Kinmoth: Bleeding after perfusion for open heart surgery. Brit. med. J.1960, 73.Google Scholar
  146. 133.
    Salisbury, P. F.: Extracorporeal circulation as an aid to cardiac surgery. In Handbuch der Thoraxchirurgie, Bd. 1, S. 695, 1958.Google Scholar
  147. 134.
    Sanger, P. W., F. H. Taylor, F. Robiscek, H. J. Dvorak andE. R. Stan: Experiences with direct-vision repair of congenital cardiovascular disorders using the rotating disc oxygenator. N.C. med. J.20, 88 (1959).Google Scholar
  148. 135.
    Sarajas, H. S. S., R. Kristoffersson andM. M. Frick: Release of adenosine triphosphate and serotonin from injured cellular blood elements in extracorporeal circuits. Nature (Lond.)184, 1127 (1959).Google Scholar
  149. 136.
    Schermer, S.: Die Blutmorphologie der Laboratoriumstiere, S. 85. Leipzig: Johann Ambrosius Barth 1958.Google Scholar
  150. 137.
    Schmutzer, K. J.: Intra- und postoperative Problem bei der Anwendung des extrakorporalen Kreislaufs. Langenbecks Arch. klin. Chir.292, 666 (1959).Google Scholar
  151. 138.
    Schneider, C. L.: Fibrin embolism. (Disseminated intravascular coagulation) with defibrination as one of the end results during placenta abruptio. Surg. Gynec. Obstet.92, 27 (1951).Google Scholar
  152. 139.
    Schneider, D. L.: Release of anticoagulant during shock of experimental embolism. Amer. J. Obstet. Gynec.65, 245 (1953).Google Scholar
  153. 140.
    Schneider, C. L.: Rapid estimation of plasma fibrinogen concentration and its use as a guide to therapy of intravascular defibrination. Amer. J. Obstet. Gynec.64, 141 (1952).Google Scholar
  154. 141.
    Senning, A.: Erfahrungen in der Herzchirurgie mit der Herz-LungenMaschine. Thoraxchirurgie6, 36 (1959).Google Scholar
  155. 142.
    Senning, A.: Plasma-heparin concentration in extracorporeal circulation. Acta chir. scand.117, 55 (1959).Google Scholar
  156. 143.
    Shanberge, J. N., A Barbas andE. E. Regan: The effect of protamine on thromboplastin generation. J. Lab. clin. Med.52, 744 (1958).Google Scholar
  157. 144.
    Shelley, W. B., M. P. Hodgkins andM. B. Visscher: Studies on the toxicity of protamine. Proc. Soc. exp. Biol. (N.Y.)50, 300 (1942).Google Scholar
  158. 145.
    Shellito, J. G., B. H. Buck, E. P. Carreau, R. H. Robinson andA. Aytay: The use of citrated blood in extracorporeal circulation. Amer. Surg.25, 796 (1959).Google Scholar
  159. 146.
    Sherry, S., andN. Alkjaersig: Studies on the fibrinolytic enzyme of human plasma. Thromb. diath. haemorrhag.1, 264 (1957).Google Scholar
  160. 147.
    Shinowara, G. Y.: Enzyme studies on human blood. The isolation and characterisation of the thromboplastic cell and plasm components. J. Lab. clin. Med.38, 11 (1951).Google Scholar
  161. 148.
    Smith, J.: Pulmonary embolism and 5-hydroxytryptamine. Lancet1956 I, 240.Google Scholar
  162. 149.
    Soulier, J. P.: Les modifications du Ca dans les transfusions massives et la circulation extracôrporéale utilisant du sang citraté. Rev. Hémat.13, 437 (1958).Google Scholar
  163. 150.
    Soulier, J. P., J. Matthey, A. G. le Bolloch, Ph. Daumet etH. Fayet: Syndromes hémorrhagiques mortels avec incoagulabilité totale par défibrination et avec fibrinolyse. C.R. 3ieme Congr. Soc. Intern. Europ. Hématol. Rome 1951. Ediz. Med. Scientif. Rome 1952, p. 755.Google Scholar
  164. 151.
    Spohn, K., E. Kolb, R. Heizel, R. Kratzert, W. Wenz, W. Woener, H. G. Lasch, H. H. Sessner, W. Raule, U. Gittstein, E. Kuhn u.K. Schreiner: 30 Ergebnisse mit der Herz-Lungen-Mschine nachCrafoord-Senning. Langenbecks Arch. klin. Chir.289, 705 (1958).Google Scholar
  165. 152.
    Stefanini, M., andI. S. Murphy: Studies on platelets. XIV. Human platelets as source of antifibrinolysin. J. clin. Invest.35, 355 (1956).Google Scholar
  166. 153.
    Thies, H. A., u.J. Lindner: Tierexperimentelle Untersuchungen zur Pathologie und Histochemie der Blutgerinnung. Ergebn. Bluttransfusionsforsch.4, 239 (1959).Google Scholar
  167. 154.
    Thies, H. A.: Vortr. 3. Hamburger Symp. Blutgerinnung.Google Scholar
  168. 155.
    Thompson, W. H.: Die physiologische Wirkung der Protamine und ihrer Spaltungsprodukte. Z. physiol. Chem.29, 1 (1900).Google Scholar
  169. 156.
    Vandendriessche, R.: Dissociatie van de thromboplastische en heparine-neutralisierende werking van bloedplaatjes. Acta clin. belg.13, 583 (1958).Google Scholar
  170. 157.
    Vaysse, J., N. Du Bouchet, Cl. de Gaudart D'Allaines, D. Laurent, J. L. Chlevrier, G. Ricordeau, B. Jaulnes, J. Mirabel, B. J. Latscha, G. Arfel, M. Vallon etJ. de Gaudart d'Allaines: Le coeur-poumon a membrane pulmonaire artificielle deJ. André Thomas. Sem Hôp. Paris35, 722 (1959).Google Scholar
  171. 158.
    Waaler, B. J.: Contact activation in the intrinsic blood clotting system. Scand. J. clin. Lab. Invest.11, Suppl. 37 (1959).Google Scholar
  172. 159.
    Weiner, A. E., D. E. Reid andC. C. Roby: Incoagulable blood in severe premature separation of the placenta. A method of management. Amer. J. Obstet. Gynec.66, 475 (1953).Google Scholar
  173. 160.
    Weiss, W. A., J. S. Gilman, A. J. Catenacci andA. E. Osterberg: Heparin neutralisation with polybrene administered intravenously. J. Amer. med. Ass.166, 603 (1958).Google Scholar
  174. 161.
    Wessler, S., andL. E. Morris: Studies in intravascular coagulation. IV. The effect of heparin and dicumarol on serum-induced venous thrombosis. Circulation12, 553 (1955).Google Scholar
  175. 162.
    Winterstein, A.: Heparin. Vortr. auf der 9. Tagg Dtsch. Ges. für Bluttransfusion, Salzburg, Sept. 1959.Google Scholar
  176. 163.
    Wolf, P.: A modification for routine laboratory use ofStefanini's method of estimating factor V activity in human oxalated plasma. J. clin. Path.6, 34 (1951).Google Scholar
  177. 164.
    Wolldridge, L. C.: Über intravasculäre Gerinnunge. Arch. Anat. u. Physiol. 1886, 397.Google Scholar
  178. 165.
    Wright, T. A., J. Darte andW. T. Mustard: Postoperative bleeding after extracorporeal circulation. Canad. J. Surg.2, 142 (1959).Google Scholar
  179. 166.
    Wulff, H. B., I. M. Nilson u.J. Svedberg: Bekämpfung der postoperativen Blutungsgefahr bei der Anwendung einer Herz-Lungen-Maschine. Thoraxchirurgie7, 140 (1959).Google Scholar
  180. 167.
    Zenker, R.: Ergebnisse experimenteller Untersuchungen während des extrakorporalen Kreislaufs. Langenbecks Arch. klin. Chir.287, 255 (1957).Google Scholar
  181. 168.
    Zenker, R., G. Heberer, H. G. Borsti, H. Gehl, W. Klinner, R. Beer u.M. Schmidt-Mende: Dtsch. med. Wschr.84, 577, 649 (1959).Google Scholar
  182. 169.
    Zucker, M. B.: Serotonin (5-Hydroxytryptamine), hematological aspects. Progr. Haemat.2, 206 (1959).Google Scholar

Copyright information

© Springer-Verlag 1961

Authors and Affiliations

  • R. Gross
    • 1
  • R. Holemans
    • 1
  1. 1.Aus der Medizinischen Univ.-Klinik MarburgGermany

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