Acta Neurochirurgica

, Volume 87, Issue 3–4, pp 129–133 | Cite as

Stable-Xenon-CT: Effects of Xenon inhalation on EEG and cardio-respiratory parameters in the human

  • K. Holl
  • N. Nemati
  • E. Kohmura
  • M. R. Gaab
  • M. Samii


The effects of inhalation of a 33% Xenon-O2 mixture over a period of 5 minutes on EEG and cardio-respiratory parameters were studied in 18 human volunteers. This dosage is similar to that used clinically in Xenon-CT studies. In 4 cases no EEG power change was observed during the study. In the 14 other subjects EEG variations were seen. The most prominent change was an increase in Β EEG power. No change was observed in θ and δ EEG power. The findings seem to correlate with the early induction (excitation) phase of an anaesthetic. Hyperventilation was observed before the study and increased during the Xenon inhalation. Blood pressure remained stable while the heart rate tended to decrease a little. All these changes disappeared rapidly following the termination of the Xenon inhalation. The effects are minimal and should not reduce the clinical value of CBF measurement using the Xenon-CT method.


Cerebral blood flow computed tomography electroencephalography stable xenon 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Clark DL, Rosner BS (1973) Neurophysiologic effects of general anesthetics: I. The Electroencephalogram and sensory evoked responses in man. Anesthesiology 38: 564–582PubMedGoogle Scholar
  2. 2.
    Gündling P, Haneder J, Gaab MR (1985) Correlation between CBF and pCO 2, pO 2, pH, hemoglobin, blood pressure, age, and sex. In: Hartmann A, Hoyer E (eds) Cerebral blood flow and metabolism measurement. Springer, Berlin Heidelberg New York, pp 51–55Google Scholar
  3. 3.
    Gur D, Yonas H, Jackson DL, Wolfson SK Jr, Rockette H, Good WF, Maitz GS, Cook EE, Arena VC (1985) Measurement of cerebral blood flow during Xenon inhalation as measured by the microspheres method. Stroke 16: 871–874PubMedGoogle Scholar
  4. 4.
    Junck L, Dhawan V, Thaler HT, Rottenberg DA (1985) Effects of Xenon and Krypton on regional cerebral blood flow in the rat. J CBF Metabol 5: 126–132Google Scholar
  5. 5.
    Kohmura E, Gürtner P, Holl K, Nemati N, Stoppe G, Lerch KD, Samii M (1986) Erfahrungen mit der Inhalation eines 33%igen Xenon-(stable-)Sauerstoffgemisches im Zusammenhang mit einer neuen Methode zur lokalen Hirndurchblutungsmessung. RöFo 144: 531–536Google Scholar
  6. 6.
    Martin JT, Faulconer A Jr, Bickford RG (1959) Electroencephalography in anesthesiology. Anesthesiology 20: 359–376PubMedGoogle Scholar
  7. 7.
    Morris LE, Knott JR, Pittinger CB (1955) Electroencephalographic and blood gas observations in human surgical patients during Xenon anesthesia. Anesthesiology 16: 312–319PubMedGoogle Scholar
  8. 8.
    Pittinger CB, Moyens J, Cullen SC, Featherstone RM, Gross G (1953) Clinicopathologic studies associated with Xenon anesthesia. Anesthesiol 14: 10–17Google Scholar
  9. 9.
    Segawa H, Wakai S, Tamura A, Yoshimasu N, Nakamura O, Ohta M (1983) Computed tomographic measurement of local cerebral blood flow by Xenon enhancement. Stroke 14: 356–362PubMedGoogle Scholar
  10. 10.
    Yonas H, Grundy B, Gur, Shabason L, Wolfson SK Jr, Cook EE (1981) Side effects of Xenon inhalation. J Comput Assist Tomogr 5: 591–592PubMedGoogle Scholar
  11. 11.
    Yonas H, Wolfson SK Jr, Gur D, Latchaw RE, Good WF, Leanza R, Jackson DL, Jannetta PJ, Reinmuth OM (1984) Clinical experience with the use of Xenon-enhanced CT blood flow mapping in cerebral vascular disease. Stroke 15: 443–450PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • K. Holl
    • 1
  • N. Nemati
    • 1
  • E. Kohmura
    • 1
  • M. R. Gaab
    • 2
  • M. Samii
    • 1
  1. 1.Department of NeurosurgeryNordstadt HospitalHannoverGermany
  2. 2.Department of NeurosurgeryMedical School HannoverHannoverGermany

Personalised recommendations