Prevention of vasospasm in subarachnoid haemorrhage. A controlled study with nimodipine
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A prospective randomized double blind study was conducted in 70 patients suffering from subarachnoid haemorrhage, due to aneurysm rupture, to determine if the use of nimodipine reduces the severity of ischaemic deficits secondary to vasospasm.
At the end of the study, two patients had severe deficit or died in the treated group, while 10 had a bad outcome in the placebo group. Angiographic vasospasm was not significantly different in its frequency or its severity between the two groups. However, the association of extensive and diffuse vasospasm was less frequent in the nimodipine group.
This study confims the effectiveness of Nimodipine in reducing the occurrence of neurological deficit due to vasospasm, even if this action is not observed in all cases.
KeywordsSubarachnoid haemorrhage aneurysms cerebral vasospasm nimodipine
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- 1.Allen GS, Gross CJ, Henderson LM, Chou SN (1976) Cerebral arterial spasm, 4. In vitro effects of temperature serotonin analogues, large non-physiological concentration of serotonin and extra cellular calcium and magnesium on serotonin-induced contractions of the canine basilar artery. J Neurosurg 44: 585–593PubMedGoogle Scholar
- 2.Allen GS, Bahr AL (1979) Cerebral arterial spasm, 10. Reverse of acute and chronic spasm in dogs with orally administered nifedipine. Neurosurgery 4: 43–47Google Scholar
- 3.Allen GS, Ahn H, Preziosi T et al (1983) Cerebral arterial spasm. A controlled trial of nimodipine in patients with subarachnoid haemorrhage. New England Med 308: 619–624Google Scholar
- 4.Auer LM (1982) Pial arterial and venous reaction to intravenous infusion of nimodipine in cats. J Neurol Sci 26: 213–218Google Scholar
- 5.Auer LM, Ito H, Suzuki H, Ohta (1982) Prevention of symptomatic vasospasm by topically applied nimodipine. Acta Neurochir (Wien) 63: 297–302Google Scholar
- 9.Fischer CM, Kistler JP, Davis JM (1983) Relation of cerebral vasospasm to subarachnoid haemorrhage visualized by computerized tomographic scanning Neurosurgery 6: 1–8Google Scholar
- 10.Kazda S, Hoffmeister F, Garthoff B, Towart R (1979) Prevention or the post ischaemic impaired reperfusion of the brain by nimodipine. Acta Neurol Scand [Suppl] 72: 358–359Google Scholar
- 11.Kazda S, Towart R (1982) Nimodipine: a new calcium antagonist drug with a preferential cerebro-vascular action. Acta Neurochir (Wien) 63: 259–265Google Scholar
- 16.Vermeulen M, Lindsay W, Murray D (1984) Antifibrinolytic treatment in subarachnoid haemorrhage. New England J Med 311: 432–437Google Scholar
- 17.Voldby B, Buhl OF, Petersen S (1981) Modification of cerebral vasospasm by intraventricular administration of a calcium antagonist in the dog. Acta Neurochir (Wien) 59: 287Google Scholar