Clinical Rheumatology

, Volume 17, Issue 4, pp 329–332

Granulomatous amoebic encephalitis caused byAcanthamoeba in a patient with systemic lupus erythematosus

  • J. Koide
  • E. Okusawa
  • T. Ito
  • S. Mori
  • T. Takeuchi
  • S. Itoyama
  • T. Abe
Case Report

Abstract

A 25-year-old chronically immunosuppressed woman with systemic lupus erythematosus (SLE) died after developing subacute granulomatous encephalitis caused byAcanthamoeba. Amoebic trophozoites were also found in the lung, suggesting a primary pulmonary focus of infection. The infectious encephalitis was difficult to differentiate from a flare-up of central nervous system lupus. This case illustrates thatAcanthamoeba can cause fatal encephalitis in lupus patients, as well as in patients with acquired immunodeficiency syndrome as previously reported. To our knowledge, this is the first reported case of granulomatous amoebic encephalitis due toAcanthamoeba in a patient with SLE.

Keywords

Acanthamoeba Granulomatous amoebic encephalitis Opportunistic Infection Systemic lupus erythematosus 

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Copyright information

© Clinical Rheumatology 1998

Authors and Affiliations

  • J. Koide
    • 1
  • E. Okusawa
    • 3
  • T. Ito
    • 1
  • S. Mori
    • 1
  • T. Takeuchi
    • 1
  • S. Itoyama
    • 2
  • T. Abe
    • 1
  1. 1.Second Department of Internal MedicineSaitama Medical Centre, Saitama Medical School, SaitamaSaitama 350Japan
  2. 2.Department of PathologySaitama Medical Centre, Saitama Medical SchoolSaitama 350Japan
  3. 3.Department of Parasitology, School of MedicineKeio UniversityTokyoJapan

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