Clinical Rheumatology

, Volume 17, Issue 4, pp 271–276 | Cite as

Urinary excretion of the pyridinium cross-links of collagen in systemic lupus erythematosus

  • Y. Kipen
  • R. Will
  • B. J. G. Strauss
  • E. F. Morand
Original Article


The aim of this study was to measure the urinary excretion of the pyridinium cross-links of collagen and to determine their usefulness as markers of reduced bone mineral density in systemic lupus erytgematosus (SLE). All female SLE patients managed at a single centre were invited to participate in a cross-sectional study of urinary pyridinium cross-links excretion (HPLC), bone mineral density (DXA), and SLE-related variables. Ninety-one women with SLE were studied, 35 of whom were postmenopausal. Pyridinoline/Creatinine (Pyd/Cr) and deoxypyridinoline/Cr (Dpd/Cr) levels in postmenopausal women were significantly increased compared with premenopausal values (p=0.010 andp=0.004, respectively). Univariate linear regression analysis revealed a significant association of Dpd/Cr with reduced femoral neck and lumbar spine BMD (p=0.001,p<0.001), and of Pyd/Cr with reduced femoral neck BMD (p=0.020). In addition, the association of Pyd/Cr with reduced lumbar spine BMD approached significance (p=0.055). Stepwise multiple linear regression analysis adjusting for other variables confirmed a significant association of Dpd/Cr with reduced lumbar spine BMD (p=0.006), and a significant association of both Pyd/Cr and Dpd/Cr with postmenopausal status (p=0.003,p<0.001). It was concluded that in this SLE population, the urinary excretion of Dpd/Cr was a useful marker of reduced BMD at the lumbar spine. Menopausal status was a major predictor of cross-links excretion in SLE.


Bone mineral density Pyridinium crosslinks Systemic lupus erythematosus 


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Copyright information

© Clinical Rheumatology 1998

Authors and Affiliations

  • Y. Kipen
    • 1
  • R. Will
    • 4
  • B. J. G. Strauss
    • 2
  • E. F. Morand
    • 3
  1. 1.Department of RheumatologyMonash Univesity Department of Medicine, Monash Medical CentreMelbourneAustralia
  2. 2.Body Composition LaboratoryMonash University Department of Medicine, Monash Medical CentreMelbourneAustralia
  3. 3.Centre for Inflammatory DiseasesMonash University Department of Medicine, Monash Medical CentreMelbourneAustralia
  4. 4.Department of RheumatologyRoyal Perth Rehabilitation HospitalPerthAustralia

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