Russian Chemical Bulletin

, Volume 45, Issue 11, pp 2602–2609 | Cite as

Synthesis of biologically active compounds based on 2-ferrocenylmethylene-3-quinuclidone

  • E. I. Klimova
  • L. Ruiz Ramirez
  • M. Martinez Garcia
  • R. G. Espinosa
  • N. N. Meleshonkova
Organometallic Chemistry

Abstract

Biologically active nitrogen heterocycles (1–7) containing ferrocene and quinuclidine fragments were synthesized. 3-Methylene-2-ferrocenylmethylenequinuiclidine forms adducts withN-phenylimides of azodicarboxylic (the structure was established by X-ray structural analysis) and malefic acids. 3-Methylene-2-fer-rocenylmethylenequinticlidine also undergoes [4+2]-cyclodimerization when heated and adds salts of the 3-methyl-2-ferrocenylmethyleneI-azoniabicyclo[2.2.2]oct-3-yl cation at the terminal methylene group to form a linear addition product.

Key words

ferrocene quinuclidine pyrazoline pyrimidine ferrocenyl-1,3-dime [4+2]cycloaddition carbocations alkylation dimerization X-ray structural analysis 

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Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • E. I. Klimova
    • 1
    • 2
  • L. Ruiz Ramirez
    • 1
  • M. Martinez Garcia
    • 3
  • R. G. Espinosa
    • 3
  • N. N. Meleshonkova
    • 4
    • 2
  1. 1.Department of ChemistryMexico National Autonomic UniversityMexico D. F.Mexico
  2. 2.Institute of ChemistryMexico National Autonomic UniversityMexico D. F.Mexico
  3. 3.Department of ChemistryM. V. Lomonosov Moscow State UniversityMoscowRussian
  4. 4.Facultad de QuimicaUniversidad Nacional Autonoma de Mexico (UNAM), Departamento de Quimica Inorganica Nuclear, Circuito Interior Ciudad UniversitariaCoyoacan

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