Colloid and Polymer Science

, Volume 266, Issue 9, pp 832–835 | Cite as

Interaction of opioid molecules with PS, PC and PS/PC monolayers

  • M. A. Alsina
  • C. Mestres
  • G. Valencia
  • J. M. García Antón
  • F. Reig
Colloid Science


The interaction between opiate molecules and phosphatidylserine (PS) or phosphatidylcholine (PC) has been studied on compression isotherms and penetration kinetics. Phosphatidylcholine-opiate interactions are weak and similar in magnitude for all opiate molecules. On contrary, PS and PS/PC interact strongly and differently with opiate molecules. The differences in penetration are not directly related to the pKa or hydrophobicity of the molecules.

Key words

Opiates phosphatidylserine phosphatidylcholine penetration kinetics monolayers 


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Copyright information

© Steinkopff 1988

Authors and Affiliations

  • M. A. Alsina
    • 1
  • C. Mestres
    • 1
  • G. Valencia
    • 2
  • J. M. García Antón
    • 2
  • F. Reig
    • 2
  1. 1.Physicochemical Department, Faculty of PharmacyUniversity of BarcelonaSpain
  2. 2.Peptide Laboratory, C.I.D.C.S.I.C.BarcelonaSpain

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