Cytological alterations in alumina cream experimental epilepsy
- 27 Downloads
- 8 Citations
Summary
The cellular changes in the neighbourhood of an alumina cream epileptogenic focus and in the mirror focus in chronic experiments in cats have been studied. According the neuroglial morphology, four layers are described around the alumina cream lesion. At an ultrastructural level, an increase in gap junctions with a great amount of gliofilaments in astroglial processes are observed.
There is a decrease in the number of neurons in the vicinity of the alumina cream. Some are coated by glial processes filled with gliofilaments.
The dendrites of the pyramidal neurons in the mirror focus show long mitochondria.
The possible significance of these data, in relation with the current theories about epileptogenicity, are discussed.
Key words
Alumina cream epilepsy Experimental epilepsy Neuron NeurogliaPreview
Unable to display preview. Download preview PDF.
References
- Baleydier, C., Etude ultrastructurale des modifications du cortex cérébral au voisinage d'un foyer épileptogène à la crême d'alumine. Acta neuropath. (Berl.)20 (1972), 11–21.Google Scholar
- Delgado, J. M. R., Evaluation of permanent implantation of electrodes within the brain. EEG. Clin. Neurophysiol.7 (1955), 637–644.Google Scholar
- Fischer, J., Electron microscopic alterations in the vicinity of epileptogenic cobalt-gelatine necrosis in the cerebral cortex of the rat. Acta neuropath. (Berl.)14 (1969), 201–214.Google Scholar
- Glötzner, F. L., Membrane properties of neuroglia in epileptogenic gliosis. Brain Res.55 (1973), 159–171.PubMedGoogle Scholar
- Harris, A. B., Cortical neuroglia in experimental epilepsy. Exp. Neurol.49 (1975), 691–715.PubMedGoogle Scholar
- Kopeloff, L. M., Barrera, S. E., Kopeloff, N., Recurrent convulsive seizures in animals produced by immunologic and chemical means. Amer. J. Psychiat.98 (1942), 881–902.Google Scholar
- Mayman, C. I., Manlapaz, J. S., Ballantine, H. T., A neuropathological study of experimental epileptogenic lesions in the cat. J. Neuropathol. exp. Neurol.24 (1965), 502–511.Google Scholar
- Pollen, D. A., Trachtenberg, M. C., Neuroglia: gliosis and focal epilepsy. Science167 (1970), 1252–1253.PubMedGoogle Scholar
- Reynolds, E. S., The use of lead citrate at high pH as an electron opaque stain in electron microscopy. J. Cell. Biol.17 (1963), 208–215.PubMedGoogle Scholar
- Stercova, A., Dynamics of neurohistopathologycal changes in an epileptogenic focus produced by alumina cream in the rat, pp. 247–257. In: Comparative and Cellular Pathophysiology of Epilepsy. Z. Servit. Ed. Proceeding of a Symposium. Prague: House of the Czechoslovak Academy of Sciences. Amsterdam: Excerpta Medica Foundation. 1965.Google Scholar
- Vaquero, C. J., Glioarquitectonia de la médula espinal. Invest. Clin. (Maracaibo)13 (1972), 15–27.Google Scholar
- Westrum, L. E., White, L. E., Ward, A. A., jr., Morphology of the experimental epileptic focus. J. Neurosurg.21 (1964), 1033–1046.PubMedGoogle Scholar
- Wisniewski, H., Karczewski, W., Wisniewska, K., Neurofibrillary degeneration of nerve cells after intracerebral injections of aluminium cream. Acta neuropath. (Berl.)6 (1966), 211–219.Google Scholar