Gastroduodenal inflammation in patients with nonulcer dyspepsia
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Proper control and quantitation are important in the accurate evaluation of gastroduodenal inflammation in dyspeptic patients without ulcers or erosions as proved by endoscopy. The endoscopic findings and the gastroduodenal mucosal inflammatory cell count in 31 patients with nonulcer dyspepsia were compared with an age-matched group of 32 healthy controls. Endoscopy revealed similar mucosal changes and in similar frequency in both groups. Differential mucosal inflammatory cell count showed a statistically significant (P<0.001) increase in the neutrophil count in the gastric body, antrum, and duodenal cap of the dyspeptic group, as well as a slight but significant (P<0.05) increase in the round cell and eosinophil count of the duodenal mucosa alone. No correlation was found between the endoscopic changes and an increase in neutrophil count above a normal level determined by the healthy controls. However, an endoscopically normal mucosa was more likely to be associated with a normal neutrophil count. Active inflammation of the gastroduodenal mucosa likely accounts for the symptoms in patients with nonulcer dyspepsia.
KeywordsDyspepsia Neutrophil Count Normal Mucosa Round Cell Eosinophil Count
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- 2.Gear MWL, Barnes RJ: Endoscopic studies of dyspepsia in general practice. Br Med J 2:1136–1137, 1980Google Scholar
- 4.Sturdevent RAL, Walsh JH: Duodenal ulcer.In Gastrointestinal Disease. MH Sleisenger, JS Fordtran, (eds). Philadelphia, WB Saunders, 1978, pp 840–860Google Scholar
- 12.Shiner M, Doniach I: A study of x-ray-negative dyspepsia with reference to histologic changes in the gastric mucosa. Gastroenterology 3:313–324, 1957Google Scholar
- 16.Oddsson E, Vibeke Binder, Thorgeirsson T, Jonasson TA, Gunnlaugsson O, Marion Wulff, Jónasson K, Wulff HR, Bjarnason O, Riis P: A prospective comparative study of clinical and pathological characteristics in Icelandic and Danish patients with gastric ulcer, duodenal ulcer, and x-ray-negative dyspepsia. II. Histological results. Scand J Gastroenterol 13:489–495, 1978PubMedGoogle Scholar
- 17.Holdstock GE, Smith CL, Isaacson P: Prevalence and significance of chronic gastritis in patients undergoing endoscopy. Gut 20:A901, 1979Google Scholar
- 19.Kreuning J, Bosman FT, Kuiper G, v d Wal AM, Lindeman J: Gastric and duodenal mucosa in “healthy” individuals. An endoscopic and histopathological study of 50 volunteers. J Clin Pathol 3:69–77, 1978Google Scholar
- 20.Holdstock GE, Smith CL, Isaacson P: Prevalence and significance of duodenitis in patients undergoing endoscopy. Gut 20:A902, 1979Google Scholar
- 38.Wellbrock WLA: Duodenitis and duodenal ulcer. Ann Surg 9:533–539, 1930Google Scholar
- 40.Fitzgibbon JH, Long GB: A gastroscopic study of healthy individuals: A preliminary report. Gastroenterology 1:67–71, 1943Google Scholar
- 43.McCallum RW, Sing D, Wollman J: Endoscopic and histological correlations of the duodenal bulb. Arch Pathol Lab Med 103:169–172, 1979Google Scholar
- 48.DeLuca VA, Winnan GG, Sheahan DG, Sanders FJ Jr, Greenlaw R, Marignani P, Gorelick FS, Bhalotra R, Goldblatt RS: Is gastroduodenitis part of the spectrum of peptic ulcer disease? J Clin Gastroenterol 3:17–22, 1981Google Scholar