Acta Neurochirurgica

, Volume 73, Issue 1–2, pp 13–23 | Cite as

Single agent therapy of interferon for brain tumours: Correlation between natural killer activity and clinical course

  • Sh. Otsuka
  • H. Handa
  • J. Yamashita
  • K. Suda
  • J. Takeuchi


The anti-tumour effect of mouse interferon (IFN) on an intracranially transplanted 203-glioma in C 57 BL mice and the natural killer (NK) activity of spleen cells were studied. As a clinical trial, five patients with glioblastomas were treated with human fibroblast IFN and the anti-tumour effect of IFN and the NK activity of peripheral blood lymphocytes were also studied. The NK activity increased after the beginning of IFN therapy but there was no remarkable antitumour effect of IFN in both mouse and human studies. There was no marked correlation between the increased NK activity and the anti-tumour effect of IFN in this study.


Brain tumour interferon natural killer 


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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Sh. Otsuka
    • 1
  • H. Handa
    • 1
  • J. Yamashita
    • 1
  • K. Suda
    • 1
    • 2
  • J. Takeuchi
    • 1
  1. 1.Department of NeurosurgeryKyoto University Medical SchoolJapan
  2. 2.Department of NeurosurgeryShiga Medical SchoolJapan

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