Acta Neurochirurgica

, Volume 118, Issue 3–4, pp 130–136 | Cite as

A primate model for acute and late cerebral vasospasm: Angiographic findings

  • T. J. Delgado-Zygmunt
  • M. A. -R. Arbab
  • Y. Shiokawa
  • N. -A. Svendgaard
Experimental Research


A subarachnoid haemorrhage (SAH) in the squirrel monkey was produced by injection of blood via a permanently implanted catheter connected to the cisterna magna and a cannula stereotactically inserted into the interpeduncular cistern. Repeated angiographic examinations of the vertebro-basilar and right internal carotid arteries revealed a biphasic vasospasm with a maximal acute spasm at ten minutes and maximal late spasm at six days after blood injection. The present study has shown that a reproducible biphasic vasospasm can be produced in the squirrel monkey and evaluated by repeated angiographic examinations. The model is suitable in the study of basic mechanisms underlying vasospasm in a primate and, due to the size of the animal, autoradiographic evaluation of the cerebral blood flow and metabolism can be performed at an acceptable cost.


Angiography squirrel monkey subarachnoid haemorrhage vasospasm 


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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • T. J. Delgado-Zygmunt
    • 1
  • M. A. -R. Arbab
    • 1
  • Y. Shiokawa
    • 2
  • N. -A. Svendgaard
    • 2
  1. 1.Neurosurgical Research DepartmentUniversity HospitalLundSweden
  2. 2.Neurosurgical DepartmentKarolinska SjukhusetStockholmSweden

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