Clinical outcome and cognitive impairment in patients with severe head injuries treated with barbiturate coma
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This study reports on clinical outcome in 38 patients with severe head injuries (posttraumatic coma for 6 hours or more) treated with barbiturate coma because of intracranial hypertension. Eighteen patients died, 4 patients remained in a severely disabled or a chronic vegetative state, and 16 patients reached the levels good recovery/ moderate disability. Six of these patients returned to work or school full time, 4 for half time and 3 were in a rehabilitation program. Fourteen patients were subjected to a comprehensive neuropsychological assessment. All patients except one exhibited varying degrees of cognitive dysfunction and 6 patients had signs of personality change. The quality of life for the majority of surviving patients was relatively good but the positive effects of barbiturate coma therapy in the age groups over 40 years appeared to be limited.
KeywordsHead injury barbiturate therapy outcome cognitive impairment
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- 1.Benton AL (1974) The revised visual retention test: clinical and experimental applications, 4th Ed. Psychological Corp., New York, pp 1–92Google Scholar
- 2.Bond MR, Brooks DN (1976) Understanding the process of recovery as a basis for the investigation of rehabilitation for the brain injured. Scand J Rehabil Med 8: 127–133Google Scholar
- 4.Carlsson C-A, von Essen C, Löfgren J (1968) Factors effecting the clinical course of patients with severe head injuries. Part 1: Influence of biological factors. Part 2: Significance of posttraumatic coma. J Neurosurg 69: 242–251Google Scholar
- 6.Desantis A, Laiacona M, Barbarotto R, Basso A, Villani R, Spagnoli D, Capitani E (1989) Neuropsychological outcome of patients operated upon for an intracranial aneurysm: analysis of general prognostic factors and of the effects of the location of the aneurysm. J Neurol Neurosurg Psychiatry 52: 1135–1140PubMedGoogle Scholar
- 7.Dureman I, Kebbon L, Österberg E (1971) A manual to the DS-battery. Psykologiförbundet AB, Stockholm, pp 1–104Google Scholar
- 9.Graham FK, Kendall BS (1960) Memory-for-Design: revised general manual. Percept Mot Skills 11: 147–188Google Scholar
- 13.Levin HS, Goldstein FC, High WM, Eisenberg HM (1988) Disproportionately severe memory deficit in relation to normal intellectual functioning after closed head injury. J Neurol Psychiatry 51: 1294–1301Google Scholar
- 19.Reitan RM (1966) Diagnostic interference of brain lesions based on psychological results. Can Psychol 7: 368–383Google Scholar
- 28.Watson CW, Kennard MA (1945) The effect of anticonvulsant drugs on recovery of function following cerebral cortical lesions. J Neurophysiol 8: 221–231Google Scholar
- 29.Wechsler D (1958) The measurements and appraisal of adult intelligence. Williams and Wilkins, BaltimoreGoogle Scholar