Archives of Virology

, Volume 140, Issue 10, pp 1763–1773 | Cite as

Antigenic relationships of hantavirus strains analysed by monoclonal antibodies

  • T. Dzagurova
  • E. Tkachenko
  • R. Slonova
  • L. Ivanov
  • E. Ivanidze
  • S. Markeshin
  • A. Dekonenko
  • B. Niklasson
  • Å. Lundkvist
Original Papers

Summary

The antigenic relationships among 71 hantavirus strains, isolated from rodent species or humans in several geographic regions, were examined by immunofluorescence assay (IFA) using human patient sera and a panel of 22 monoclonal antibodies prepared against Hantaan, Seoul, and Puumala viruses. The study included virus strains, mainly from the former USSR, for which little or no serological data were available. Fifty-nine of the 71 isolates could be placed into five antigenic groups of hantaviruses, Hantaan (HTN), Puumala (PUU), Seoul (SEO), Prospect Hill (PH), Dobrava/Belgrade (DOB). Twelve isolates were found antigenically closely related to, but distinct from, HTN (2 strains), PUU (4 strains) and PH (6 strains), respectively. The antigenic characteristics of these 12 isolates suggested two supplementary antigenic subgroups of HTN, one of PUU, and two of PH. The two antigenic subgroups of HTN included strains isolated in the Far-East of Russia. The PUU subgroup included strains isolated in European Russia as well as strains isolated in Far-Eastern Russia. The PH group comprised two subgroups, both represented by strains isolated fromM. fortis in Far-Eastern Russia. The results showed that the PUU and PH antigenic groups are more complex than previously known and that PH-like virus strains isolated in Russia are antigenically more closely related to PUU virus when compared to prototype PH virus isolated in the USA.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Brummer-Korvenkontio M, Henttonen H, Vaheri A (1982) Hemorrhagic fever with renal syndrome in Finland: ecology and virology of nephropathia epidemica. Scand J Infect Dis [Suppl] 36: 88–91Google Scholar
  2. 2.
    CDC (1993) Hantavirus pulmonary syndrome — United States. CDC Update 42: 816–820Google Scholar
  3. 3.
    Chu YK, Rossi C, LeDuc JW, Lee HW, Schmaljohn CS, Dalrymple JM (1994) Serological relationships among viruses in theHantavirus genus, familyBunyaviridae. Virology 198: 196–204PubMedGoogle Scholar
  4. 4.
    Dzagurova TK, Tkachenko EA, Petrov VA (1988) Effectiveness of tissue culture antigens for serodiagnosis of HFRS by IFA test. Vopr Virusol 1: 71–75 [in Russian]Google Scholar
  5. 5.
    Elliott RM (1990) Molecular biology of the Bunyaviridae. J Gen Virol 71: 501–522PubMedGoogle Scholar
  6. 6.
    Hjelle B, Jenison S, Torrez-Martinez N, Yamada T, Nolte K, Zumwalt R, MacInnes K, Myers G (1994) A novel hantavirus associated with an outbreak of fatal respiratory disease in the southwestern United States: evolutionary relationships to known hantaviruses. J Virol 68: 592–506PubMedGoogle Scholar
  7. 7.
    Lee HW, Lee PW, Johnson KM (1978) Isolation of the etiologic agent of Korean hemorrhagic fever. J Infect Dis 137: 298–308PubMedGoogle Scholar
  8. 8.
    Lee HW, Baek LJ, Johnson KM (1982) Isolation of Hantaan virus, the etiologic agent of Korean hemorrhagic fever, from wild urban rats. J Infect Dis 146: 638–644PubMedGoogle Scholar
  9. 9.
    Lee PW, Amyx HL, Gajdusek DC, Yanagihara RT, Goldgaber D, Gibbs CJ Jr (1982) New haemorrhagic fever with renal syndrome-related virus in indigenous wild rodents in the United States. Lancet ii: 1405Google Scholar
  10. 10.
    Lee PW, Gibbs CJ, Gajdusek DC, Yanagihara R (1985) Serotypic classification of hantaviruses by indirect immunofluorescent antibody and plaque reduction neutralization tests. J Clin Microbiol 22: 940–944PubMedGoogle Scholar
  11. 11.
    Lundkvist Å, Niklasson B (1992) Bank vole monoclonal antibodies against Puumala virus envelope glycoproteins: identification of epitopes involved in neutralization. Arch Virol 126: 93–105PubMedGoogle Scholar
  12. 12.
    Lundkvist Å, Niklasson B (1994) Haemorrhagic fever with renal syndrome and other hantavirus infections. Rev Med Virol 4: 177–184Google Scholar
  13. 13.
    Nichol ST, Spiropoulou CF, Morzunov S, Rollin PE, Ksiazek TG, Feldmann H, Sanchez A, Childs J, Zaki S, Peters CJ (1993) Genetic identification of a hantavirus associated with a outbreak of acute respiratory illness. Science 262: 914–917PubMedGoogle Scholar
  14. 14.
    Plyusnin A, Vapalahti O, Lankinen H, Lehväslaiho, Apekina N, Myasnikov Y, Kallio-Kokko H, Henttonen H, Lundkvist Å, Brummer-Korvenkontio M, Gavrilovskaya, Vaheri A (1994) Tula virus: a newly detected hantavirus carried by European common voles. J Virol 68: 7833–7839PubMedGoogle Scholar
  15. 15.
    Schmaljohn CS, Hasty SE, Dalrymple JM, LeDuc JW, Lee HW, von Bonsdorff C-H, Brummer-Korvenkontio M, Vaheri A, Tsai TF, Regnery HL, Goldgaber D, Lee PW (1985) Antigenic and genetic properties of viruses linked to hemorrhagic fever with renal syndrome. Science 227: 1041–1044PubMedGoogle Scholar
  16. 16.
    Sheshberadaran H, Niklasson B, Tkachenko EA (1988) Antigenic relationship between Hantaviruses analysed by immunoprecipitation. J Gen Virol 69: 2645–2651PubMedGoogle Scholar
  17. 17.
    Sugiyama K, Morikawa S, Matsuura Y, Tkachenko EA, Morita C, Komatsu T, Akao Y, Kitamura T (1987) Four types of haemorrhagic fever with renal syndrome viruses identified by polyclonal and monoclonal antibodies. J Gen Virol 68: 979–987PubMedGoogle Scholar
  18. 18.
    Tkachenko EA, Bashkiritsev VN, van der Groen G, Dzagurova TK, Ivanov AP, Ryltseva EV (1984) Isolation in Vero E6 cells of hantavirus fromClethrionomys glareolus captured in Bashkiria area of the USSR. Ann Soc Belg Med Trop 65: 121–135Google Scholar
  19. 19.
    Vapalahti O, Kallio-Kokko H, Salonen E-M, Brummer-Korvenkontio M, Vaheri A (1992) Cloning and sequencing of Puumala virus Sotkamo strain S and M RNA segments: evidence for strain variation in hantaviruses and expression of the nucleocapsid protein. J Gen Virol 73: 829–838PubMedGoogle Scholar
  20. 20.
    Xiao S-Y, LeDuc JW, Chu YK, Schmaljohn CS (1994) Phylogenetic analysis of virus isolates in the genusHantaviruses, familyBunyaviridae. Virology 198: 295–217Google Scholar
  21. 21.
    Yamanishi K, Dantos F, Takahashi M, Yamanouchi T, Domae K, Takahashi Y, Tanishita O (1984) Antigenic differences between two viruses isolated in Japan and Korea, that cause HFRS. J Virol 52: 231–237PubMedGoogle Scholar
  22. 22.
    Yan DY, Xie YJ, Zhang CA, McCormick JB, Sanchez A (1986) New isolates of HFRS viruses in Sichuan, China and characterisation of antigenic differences by monoclonal antibodies. Lancet i: 203Google Scholar
  23. 23.
    Yanagihara R, Gajdusek DC (1988) Hemorrhagic fever with renal syndrome: a historical perspective and review of recent advances. In: Gear JHS (ed) Handbook on viral and rickettsial hemorrhagic fevers. CRC Press, Boca Raton, pp 151–188Google Scholar

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • T. Dzagurova
    • 1
  • E. Tkachenko
    • 1
  • R. Slonova
    • 2
  • L. Ivanov
    • 3
  • E. Ivanidze
    • 4
  • S. Markeshin
    • 5
  • A. Dekonenko
    • 1
  • B. Niklasson
    • 6
    • 7
  • Å. Lundkvist
    • 6
    • 8
  1. 1.Institute of Poliomyelitis and Viral EncephalitidesAcademy of Medical ScienceMoscow
  2. 2.Institute of Epidemiology and MicrobiologyAcademy of Medical ScienceVladivostok
  3. 3.Anti-plague StationKhabarovskRussia
  4. 4.Anti-plague StationGeorgia
  5. 5.Anti-plague StationSimferopolUkraine
  6. 6.Swedish Institute for Infectious Disease ControlStockholm
  7. 7.National Defense Research EstablishmentUmeå
  8. 8.Karolinska InstituteStockholmSweden

Personalised recommendations