, Volume 8, Issue 3, pp 225–229

The functions of saliva

  • Mitchell D. Kaplan
  • Bruce J. Baum


Oral health is determined to a considerable extent by our ability to produce saliva. Not only must adequate amounts be produced, but a large number of specific proteins also must be secreted for the mouth to function properly. This brief review is directed at describing (1) how saliva is secreted, (2) the consequences of decreased salivary function, (3) the components necessary for oral homeostasis, and (4) the common causes of salivary hypofunction.

Key words

Salivary secretion Oral function Alimentary process Deglutition Deglutition disorders 


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  1. 1.
    Baum BJ: Salivary gland fluid secretion during aging.JAGS 37:453–458, 1989Google Scholar
  2. 2.
    Baum BJ: Saliva secretion and composition.Front Oral Physiol 6:126–134, 1987Google Scholar
  3. 3.
    Mandel ID: Sialochemistry in diseases and clinical situations affecting salivary glands.Crit Rev Clin Lab Sci 12:321–366, 1980Google Scholar
  4. 4.
    Fox PC, van der Ven PF, Sonies BC, Weiffenbach JM, Baum BJ: Xerostomia: evaluation of a symptom with increasing significance.JADA 110:519–525, 1985Google Scholar
  5. 5.
    Ship JA, Fox PC, Baum BJ: How much saliva is enough? ‘Normal’ function defined.JADA 122:63–69, 1991Google Scholar
  6. 6.
    Dawes C: Physiological factors affecting salivary flow rate, oral sugar clearance, and the sensation of dry mouth in man.J Dent Res 66:648–653, 1987Google Scholar
  7. 7.
    Moreno EC, Varughese K, Hay DI: Effect of human salivary proteins on the precipitation kinetics of calcium phosphate.Calcif Tissue Int 28:7–16, 1979Google Scholar
  8. 8.
    Schlesinger DH, Hay DI: Complete covalent structure of a proline-rich phosphoprotein, PRP-2, an inhibitor of calcium phosphate crystal growth from human parotid saliva.Int J Peptide Res 27:373–379, 1986Google Scholar
  9. 9.
    Levine MJ, Reddy MS, Tabak LA, Loomis RE, Bergey EJ, Jones PC, Cohen RE, Stinson MW, Al-Hashimi I: Structural aspects of salivary glycoproteins.J Dent Res 66:436–441, 1987Google Scholar
  10. 10.
    Mandel ID: The functions of saliva.J Dent Res 66:623–627, 1987Google Scholar
  11. 11.
    Bradway SD, Bergey EJ, Jones PC, Levine MJ: Oral mucosal pellicle: adsorption and transpeptidation of salivary components to buccal epithelial cells.Biochem J 261:887–896, 1989Google Scholar
  12. 12.
    Bradway SD, Scannapieco FA, Zawacki S, Rama Subbu N, Levine MJ: Mode of interaction of salivary proteins with mucosal epithelium.J Dent Res 69:319, 1990Google Scholar
  13. 13.
    Marti U, Burwen SJ, Jones AL: Biological effects of epidermal growth factor, with emphasis on the gastrointestinal tract and liver: an update.Hepatology 9:126–138, 1989Google Scholar
  14. 14.
    Valdez IH, Fox PC: Interactions of the salivary and gastrointestinal systems: I. The role of saliva in digestion.Dig Dis 9:125–131, 1991Google Scholar
  15. 15.
    Royce LS, Baum BJ: Physiologic levels of salivary epidermal growth factor stimulate migration of an oral epithelial cell line.Biochim Biophys Acta 1092:401–403, 1991Google Scholar
  16. 16.
    Wang S-L, Milles M, Wu-Wang C-Y, Liu J, Slomiany A, Slomiany BL: Identification of epidermal growth factor receptor in human buccal mucosa.Arch Oral Biol 35:823–828, 1990Google Scholar
  17. 17.
    Gray MR, Donnelly RJ, Kingsworth AN: Role of salivary epidermal growth factor in the pathogenesis of Barrett's columnar lined oesophagus.Br J Surg 78:1461–1466, 1991Google Scholar
  18. 18.
    Mandel ID: Relation of saliva and plaque to dental caries.J Dent Res 53:246–266, 1974Google Scholar
  19. 19.
    Helm IF: Role of saliva in esophageal function and disease.Dysphagia 4:76–84, 1989Google Scholar
  20. 20.
    McGee JR, Mestecky J, Dertzbaugh MT, Eldridge JH, Hirasawa M, Kiyono H: The mucosal immune system: from fundamental concepts to vaccine development.Vaccine 10:75–88, 1992Google Scholar
  21. 21.
    Yeh C-K, Handelman B, Fox PC, Baum BJ: Further studies of salivary inhibition of HIV-1 infectivity.J AIDS 5:898–903, 1992Google Scholar
  22. 22.
    Xu T, Levitz SM, Diamond RD, Oppenheim FG: Anticandidal activity of major human salivary histatins.Infect Immun 59:2549–2554, 1991Google Scholar
  23. 23.
    Kanehisa J, Doi S, Yamanaka T, Takeuchi H: Salivary fibronectin in man: an immunoblotting, radioimmunoassay and immunohistochemical study.Arch Oral Biol 36:265–272, 1991Google Scholar
  24. 24.
    Simpson WA, Beachey EH: Adherence of group A streptococci to fibronectin on oral epithelial cells.Infect Immun 39:275–279, 1983Google Scholar
  25. 25.
    Simpson WA, Hasty DL, Beachey EH: Binding of fibronectin to human buccal epithelial cells inhibits the binding of type 1 fimbriatedEscherichia coli.Infect Immun 48:318–323, 1985Google Scholar
  26. 26.
    Weiffenbach JM, Fox PC, Baum BJ: Taste and salivary function.Proc Natl Acad Sci USA 83:6103–6106, 1986Google Scholar
  27. 27.
    Fox PC, Busch KA, Baum BJ: Subjective reports of xerostomia and objective measures of salivary gland performance.JADA 115:581–584, 1987Google Scholar
  28. 28.
    Hughes CV, Baum BJ, Fox PC, Marmary Y, Yeh C-K, Sonies BC: Oral-pharyngeal dysphagia: a common sequela of salivary gland dysfunction.Dysphagia 1:173–177, 1987Google Scholar
  29. 29.
    Main BE, Calman KC, Ferguson MM, Kaye SB, MacFarlane TW, Mairs RJ, Samaranayake LP, Willox J, Welsh J: The effect of cytotoxic therapy on saliva and oral flora.Oral Surg 58:545–548, 1984Google Scholar
  30. 30.
    Valdez IH, Atkinson JC, Ship JA, Fox PC: Major salivary gland function in patients with radiation-induced xerostomia: flow rates and sialochemistry.Int J Radiat Oncol Biol Phys 25:41–47, 1992Google Scholar
  31. 31.
    Atkinson JC, Fox PC: Salivary gland dysfunction.Clin Geriatr Med 8:499–511, 1992Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1993

Authors and Affiliations

  • Mitchell D. Kaplan
    • 1
  • Bruce J. Baum
    • 1
  1. 1.CIPCB/NIDR/NIHBethesdaUSA

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