Response properties of neurons in nuclei of the mouse inferior colliculus
- 140 Downloads
Extracellular recordings were obtained from 414 single-units in the inferior colliculi (IC) of tranquilized inbred C57BL/6J mice.
Spontaneous activity was encountered in 48% of units in the ventrolateral nucleus (ICVL), in 47% of units in the pericentral and external nuclei (ICP-ICX), and in 39% of units in the dorsomedial nucleus (ICDM).
PSTH response patterns typical of IC neurons of other species were found in the mouse (Figs. 2 and 3). These included phasic on and or bursts, off-, sustained excitation, “pauser,” “chopper,” and sustained inhibition of spontaneous activity. Despite the mouse's poor low-frequency hearing, phase-locked responses also occurred. Responses with latencies of up to 100–200 ms which were only driven by relatively long-duration tones were also observed. Other units showed off-suppression of spontaneous activity which could last for several seconds following long-duration tones (Fig. 3).
Sustained responses (excitatory and inhibitory) were most prominent in ICVL units, phasic responses in ICP-ICX units, and long-latency and off-responses in ICDM units. Habituation and “sluggish” responses were often found in ICP-ICX units, but rarely were seen in ICVL units.
Threshold tuning curves for ICVL units were typified by sharpness and low thresholds, whereas tuning curves of ICP-ICX units were often broad, had higher thresholds, and were difficult to obtain (Figs. 6 and 7). Suprathreshold response ranges of ICVL units strongly represented frequencies of 10–25 kHz, the mouse's most sensitive frequency range. Distributions of response ranges for units in other IC nuclei were more evenly distributed and included more low frequencies (Fig. 8).
KeywordsSpontaneous Activity Inferior Colliculus Tuning Curve Response Range Sustained Inhibition
Unable to display preview. Download preview PDF.
- Adams, J.C., Teas, D.C.: Organization of the posterior colliculus. J. Acoust. Soc. Amer.53, 361(A) (1973)Google Scholar
- Aitkin, L.M., Fryman, S., Blake, D.W., Webster, W.R.: Responses of neurons in rabbit inferior colliculus. I. Frequency-specificity and topographic arrangement. Brain Res.47, 77–90 (1972)Google Scholar
- Aitkin, L.M., Webster, W.R., Veal, J.L., Crosby, D.C.: Inferior colliculus. I. Comparison of response properties of neurons in central, pericentral, and external nuclei of adult cat. J. Neurophysiol.38, 1196–1207 (1975)Google Scholar
- Alford, B.R., Ruben, R.J.: Physiological, behavioral, and anatomical correlates of the development of hearing in the mouse. Ann. Otol. Rhinol. Laryngol.72, 237–247 (1963)Google Scholar
- Berlin, C.I.: Hearing in mice via GSR audiometry. J. Speech Hear. Res.6, 359–368 (1963)Google Scholar
- Birch, L.M., Warfield, D., Ruben, R.J., Mikaelian, D.O.: Behavioral measurements of pure tone thresholds in normal CBA-J mice. J. Aud. Res.8, 459–468 (1968)Google Scholar
- Bock, G.R., Webster, W.R., Aitkin, L.M.: Discharge patterns of single units in inferior colliculus of the alert cat. J. Neurophysiol.35, 265–277 (1972)Google Scholar
- Brown, A.M.: High levels of responsiveness from the inferior colliculus of rodents at ultrasonic frequencies. J. comp. Physiol.83, 393–406 (1973)Google Scholar
- Clopton, B.M., Winfield, J.A.: Tonotopic organization in the inferior colliculus of rat. Brain Res.56, 355–358 (1973)Google Scholar
- Deol, M.S.: Anatomy and development of mutants pirouette, shaker-1, and waltzer in the mouse. Proc. R. Soc. Lond. (Biol.)145, 206–213 (1956)Google Scholar
- Drager, U.C.: Receptive fields of single cells and topography in the mouse visual cortex. J. Comp. Neurol.160, 269–290 (1975)Google Scholar
- Ehret, G.: Age-dependent hearing loss in normal hearing mice. Naturwissenschaften61, 506–507 (1974)Google Scholar
- Erulkar, S.D.: Physiological studies of the inferior colliculus and medial geniculate complex. In: Handbook of sensory physiology, Vol. 5 (eds. W.D. Keidel, W.D. Neff) Berlin-Heidelberg-New York: Springer 1975Google Scholar
- Finck, A., Berlin, C.I.: Comparison between single unit responses in the auditory nerve and GSR determined thresholds in mice. J. Aud. Res.5, 1–9 (1965)Google Scholar
- Hack, M.H.: The developmental Preyer reflex in the sh-1 mouse. J. Aud. Res.8, 449–457 (1968)Google Scholar
- Henry, K.R.: Audiogenic seizure susceptibility induced in C57BL/6J mice by prior auditory exposure. Science158, 938–940 (1967)Google Scholar
- Hind, J.E., Goldberg, J.M., Greenwood, D.D., Rose, J.E.: Some discharge characteristics of single neurons in inferior colliculus of Cat. II. Timing of the discharges and observations on binaural stimulation. J. Neurophysiol.26, 321–341 (1963)Google Scholar
- Kelly, J.B., Masterton, B.: Auditory sensitivity of the albino rat. J. Comp. Physiol. Psychol.91, 930–936 (1977)Google Scholar
- Mast, T.E., Chung, D.Y.: Functional organization of inferior colliculus of chinchilla. J. Aud. Res.13, 289–295 (1973)Google Scholar
- Merzenich, M.M., Reid, M.D.: Representation of the cochlea within the inferior colliculus of the cat. Brain Res.77, 397–415 (1974)Google Scholar
- Morest, D.K.: Noncortical neuronal architecture of the inferior colliculus of cat. Anat. Rec.154, 447(A) (1966)Google Scholar
- Pfeiffer, R.R.: Classification of response patterns of spike discharges for units in the cochlear nucleus: Tone-burst stimulation. Exp. Brain Res.1, 220–235 (1966)Google Scholar
- Ralls, K.: Auditory sensitivity in mice:Peromyscus andMus musculus. Anim. Behav.15, 123–128 (1967)Google Scholar
- Reale, R.A., Glaser, E.M.: Tone burst and sweep tone responses of single units in the inferior colliculus of the unanesthetizedparalyzed albino rat. New York: Society for Neuroscience 1975Google Scholar
- Robards, M.J., Watkins, O.W. III, Masterton, R.B.: An anatomical study of some somesthetic afferents to the intercollicular terminal zone of the midbrain of the opossum. J. Comp. Neurol.170, 499–524 (1976)Google Scholar
- Rockel, A.J., Jones, E.G.: The neuronal organization of the inferior colliculus of the adult cat. J. Comp. Neurol.147, 11–60 (1973a)Google Scholar
- Rockel, A.J., Jones, E.G.: Observations on the fine structure of the central nucleus of the inferior colliculus of the cat. J. Comp. Neurol.147, 61–92 (1973b)Google Scholar
- Saunders, J.C., Hirsch, K.A.: Changes in cochlear microphonic sensitivity after priming C57BL/6J mice at various ages for audiogenic seizures. J. Comp. Physiol. Psychol.90, 212–220 (1976)Google Scholar
- Sher, A.E.: The embryonic and postnatal development of the inner ear of the mouse. Acta Otolaryngol. Suppl.285, 1–77 (1971)Google Scholar
- Sidman, R.L., Angevine, J.B., Pierce, E.T.: Atlas of the mouse brain and spinal cord. Cambridge, Massachusetts: Harvard University Press 1971Google Scholar
- Sidman, R.L., Green, M.C., Appel, S.H.: Catalog of the Neurological Mutants of the Mouse. Cambridge, Massachusetts: Harvard University Press 1965Google Scholar
- Suga, N.: Feature extraction in the auditory system. In: Basic mechanisms in hearing (ed. A.R. Moller). New York: Academic Press 1973Google Scholar
- Willott, J.F., Urban, G.P.: Auditory neurons of the mouse selectively responsive to long duration stimuli. Anaheim, California: Society for Neuroscience 1977Google Scholar