Calcified Tissue International

, Volume 53, Issue 1, pp 17–20 | Cite as

A clinical trial on the effects of a combination of elcatonin (Carbocalcitonin) and conjugated estrogens on vertebral bone mass in early postmenopausal women

  • M. Meschia
  • M. Brincat
  • P. Barbacini
  • P. G. Crossignani
  • W. Albisetti
Clinical Investigations

Summary

The study was carried out to determine the effect of a combination regimen of a small dose of calcitonin added to conjugated estrogens with medroxyprogesterone acetate on vertebral bone mass in early postmenopausal women. Comparisons were made with groups of women on calcitonin alone, on conjugated estrogens with medroxyprogesterone acetate alone, or on no treatment. The study was carried out over a 2-year period. The results of the study suggest that the combined regimen of calcitonin and estrogens increased vertebral bone mass in early postmenopausal women to a greater extent than calcitonin alone or estrogen alone. Increases in vertebral bone mass of 11.2% after 1 year and 9.2% after 2 years were demonstrated using the combined regimen. Both estrogens alone and calcitonin alone were, however, very effective in preventing rapid bone loss in the postmenopausal women studied.

Key words

Early postmenopause Vertebral bone mass Combined regimen Calcitonin Estrogen Osteoporosis 

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References

  1. 1.
    Melton LJ, Kan SH, Frye MA, et al (1989) Epidemiology of vertebral fractures in women. Am J Epidemiol 129:1000–1011Google Scholar
  2. 2.
    Cummings SR, Kelsey JL, Nevitt MC, O'Dowd KJ (1985) Epidemiology of osteoporotic fractures. Epidemiol Rev 7:178–208Google Scholar
  3. 3.
    Lindsay R, Cosman F (1990) Epidemiology of osteoporosis. In: Drife JO, Studd JWW (eds) HRT and osteoporosis. Springer-Verlag, London, pp 75–85Google Scholar
  4. 4.
    Melton LJ (1988) Epidemiology of fractures. In: Riggs BL, Melton LJ III (eds) Osteoporosis: etiology, diagnosis and management. Raven Press, New York, pp 133–154Google Scholar
  5. 5.
    Horsman A, Gallagher JC, Simpson M, Nhordin BEC (1977) Prospective trial of oestrogen and calcium in postmenopausal women. Br Med J 2:789–792Google Scholar
  6. 6.
    Ettinger B, Genant HK, Cann CE (1985) Long term estrogen replacement prevents bone loss and fracture. Ann Intern Med 102:319–324Google Scholar
  7. 7.
    Weiss NS, Carol PH, Ure CL, Ballard JC, Williams AR, Darling JR (1980) Decreased risk of fractures of the hip and lower forearm with postmenopausal use of estrogen. N Engl J Med 303:1195–1198Google Scholar
  8. 8.
    Burch JC, Byrd BF, Vaughn WK (1974) The effects of long-term estrogen on hysterectomised women. Am J Obstet Gynecol 118:778–782Google Scholar
  9. 9.
    Lindsay R, Aitken JM, Anderson JB, Hart DM, MacDonald EB, Clark AC (1976) Long term prevention of postmenopausal osteoporosis by oestrogen. Lancet i:1038–1041Google Scholar
  10. 10.
    Lindsay R, Hart DM, Purdie P, Ferguson MM, Clark AC, Kraszewski A (1978) Comparative effects of oestrogen and progestagen on bone loss in postmenopausal women. Clin Sci Molec Med 54:193–195Google Scholar
  11. 11.
    Lindsay R, Hart DM, Clark DM (1984) The minimum effective dose of estrogen for prevention of postmenopausal bone loss. Obstet Gynecol 63:759–763Google Scholar
  12. 12.
    Aitken JM, Hart DM, Lindsay R (1973) Oestrogen replacement therapy for prevention of osteoporosis after oophorectomy. Br Med J 111:515–518Google Scholar
  13. 13.
    Ross RK, Paganini-Hill A, Mach JM (1984) Reduction in fractures and other effects of oestrogen replacement therapy in human population. Osteoporosis proceedings of the Copenhagen International Symposium on Osteoporosis. 1:289–297Google Scholar
  14. 14.
    Stevenson JC, Abysekera G, Hillyard CJ et al (1981) Calcitonin and the calcium regulating hormones in postmenopausal women. Effect of oestrogens. Lancet 1:693–695Google Scholar
  15. 15.
    Overgaard K, Christiansen C (1991) Long term treatment of established osteoporosis with intranasal calcitonin. Calcif Tiss Int 49 Suppl:560–63Google Scholar
  16. 16.
    Gordon GS (1984) Prevention of bone loss and fractures in women. Maturitas 6:225Google Scholar
  17. 17.
    Riggs BL, Wahner HW, Dunn WL, Mazess RB, Offord KP, Melton LJ III (1981) Differential changes in bone mineral density of the appendicular and axial skeleton with aging: relationship to spinal osteoporosis. J Clin Invest 67:328–335Google Scholar
  18. 18.
    Eastell R, Wahner HW, O'Fallon M, Amadio PC, Melton LJ III, Riggs BL (1989) Unequal decrease in bone density of lumbar spine and ultradistal radius in Colles' and vertebral fracture syndromes. J Clin Invest 83:168–174Google Scholar
  19. 19.
    Natchigall LE, Natchigall KH, Natchigall RD, Beckman E (1988) Estrogen replacement therapy. A ten year prospective study in the response to Osteoporosis. Obstet Gynecol 53:277Google Scholar
  20. 20.
    Reginster JT, Denis D, Albert M (1988) Intranasal calcitonin. A new horizon in prevention. In: Gennazani AR, Petragliga F, Volpe A, Facchinetti F (eds) Gynaecological endocrinology. Parthenon Publishing Group, pp 593–601Google Scholar
  21. 21.
    MacIntyre I, Stevenson JC, Whitehead MI, Wimalawansa SJ, Banks LM, Healy MJ (1988) Calcitonin for prevention of postmenopausal bone loss. Lancet 18:900–902Google Scholar
  22. 22.
    Mazzuoli GF, Pacitti MT, Minisola J, Celi FS, Bianchi G (1990) Effects of salmon calcitonin (sCT) on bone loss induced by ovariectomy. In: Christiansen C, Overgaard K (eds) Osteoporosis. Aalbrod Aps Aalborg, Denmark, 2, pp 1255–1257Google Scholar
  23. 23.
    Overgaard K, Hansen MA, Jansen SB, Christiansen C (1992) Effect of salcatonin given intranasally on bone mass and fracture rates in established osteoporosis: a dose response study. Br Med J 305:556–561Google Scholar
  24. 24.
    Savvas M, Studd JWW, Fogelman I, Dooley M, Montgomery J, Murby B (1988) Skeletal effects of oral estrogen compared with subcutaneous oestrogen and testosterone in postmenopausal women. Br Med J 297:331–333Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1993

Authors and Affiliations

  • M. Meschia
    • 1
  • M. Brincat
    • 2
  • P. Barbacini
    • 1
  • P. G. Crossignani
    • 1
  • W. Albisetti
    • 3
  1. 1.IIIrd Department, Obstetrics and GynaecologyUniversity of MilanItaly
  2. 2.Department of Obstetrics and GynaecologyUniversity of MaltaMalta
  3. 3.Department of OrthopaedicsUniversity of MilanItaly

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