Calcified Tissue International

, Volume 53, Issue 5, pp 362–364

Interleukin-11 inhibits bone formation in vitro

  • Francis J. Hughes
  • Gareth L. Howells
Rapid Communication


The effects of interleukin-11(IL-11) on the differentiation of osteoblast precursors was tested using a bone nodule forming assay in rat calvaria cell cultures. IL-11 caused a dose dependent inhibition of nodule formation, with 500U/ml IL-11 resulting in complete inhibition of nodule formation. IL-11 also caused a reduction in alkaline phosphatase expression in these cultures. These effects are similar to, but more potent than, the actions of IL-6 on these cells. These results indicate that IL-11 is an osteotropic cytokine and suggest that IL-11 may be an important inhibitor of bone formation in health and disease.


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Copyright information

© Springer-Verlag New York Inc. 1993

Authors and Affiliations

  • Francis J. Hughes
    • 1
  • Gareth L. Howells
    • 2
  1. 1.Department of Oral Medicine and PeriodontologyThe London Hospital Medical CollegeLondonUK
  2. 2.Department of Oral PathologyThe London Hospital Medical CollegeLondonUK

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