Sozial- und Präventivmedizin

, Volume 46, Issue 3, pp 182–185 | Cite as

Risk factors for cholangiocarcinoma in a low risk Caucasian population

  • Hannah Kuper
  • Pagona Lagiou
  • Lorelei A. Mucci
  • Rulla Tamimi
  • Vassiliki Benetou
  • Dimitrios Trichopoulos
Original Articles



Little is known about the etiology of cholangiocarcinoma, apart from its association with liver fluke infestation.


A case-control study was conducted in Athens and included six cholangiocarcinoma cases, 333 hepatocellular carcinoma cases and 360 controls with minor ailments or injuries. All subjects were interviewed and tested for hepatitis B and C infection. For all six cholangiocarcinomas, 97 hepatocellular carcinomas and 129 controls, sex steroids were determined in the blood.


Hepatitis B or C viruses, tobacco smoking, alcohol drinking and diabetes mellitus were not related to cholangiocarcinoma, but history of thyroid disease was. Estradiol levels were higher among cholangiocarcinoma cases than among the other two groups.


This study provides evidence that endocrine and autoimmune factors are important in the etiology of cholangiocarcinoma.


Cholangiocarcinoma Etiology Estradiol Thyroid disease Liver disease 



Es ist wenig bekannt über die Ätiologie des Cholangiokarzinoms, ausser dem Zusammenhang mit einer Leberegelinfektion.


Eine Fall-Kontroll-Studie mit sechs Fällen von Cholangiokarzinom, 333 von hepatozellulärem Karzinom und 360 Kontrollfällen mit kleineren Leiden und Verletzungen wurde in Athen durchgeführt. Alle Befragten wurden auf Hepatitis B und C getestet. Bei den sechs Cholangiokarzinom-Fällen, bei 97 Fällen mit hepatozellulärem Karzinom und bei 129 Kontrollfällen wurden die Geschlechtshormone im Blut gemessen.


Während zwischen Hepatitis B oder C, Rauchen, Alkohol, Diabetes Mellitus und dem Cholangiokarzinom kein Zusammenhang bestand, wurde ein solcher zwischen Schilddrüsenerkrankungen und dem Cholangiokarzinom festgestellt. Bei den Fällen mit Cholangiokarzinom war der Oestradiolwert höher als in den zwei anderen Fall-Gruppen.


Diese Studie zeigt, dass endokrine und autoimmune Faktoren wichtig für die Ätiologie des Cholangiokarzinoms sind.



On connaît très peu dé choses sur l'étiologie du cholangiocarcinome hormis son association avec la douve du foie.


Une étude cas témoins, menée à Athènes, incluait 6 cas de cholangiocarcinome, 333 carcinomes hépatocellulaires et 360 témoins souffrant d'affections bénignes ou de traumatisme. Tous les sujets interviewés ont été testés pour l'hépatite B et C. Les stéroides sexuels ont été mesurés dans le sang des 6 cas de cholangiocarcinome, 97 carcinomes hépatocellulaires et 129 témoins.


Les virus de l'hépatite B ou C, le tabagisme, la consommation d'alcool et le diabète sucré n'étaient pas associès au cholangiocarcinome, mais l'histoire de maladie thyroidienne l'était. Les taux d'estradiol étaient plus élevés parmi les cas de cholangiocarcinome que parmi les deux autres groupes.


Cette étude démontre l'importance des facteurs endocrines et auto-immuns pour l'étiologie du cholangiocarcinome.


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Copyright information

© Birkhäuser Verlag 2001

Authors and Affiliations

  • Hannah Kuper
    • 1
  • Pagona Lagiou
    • 1
    • 2
  • Lorelei A. Mucci
    • 1
  • Rulla Tamimi
    • 1
  • Vassiliki Benetou
    • 2
  • Dimitrios Trichopoulos
    • 1
    • 2
  1. 1.Department of EpidemiologyHarvard School of Public HealthBostonUSA
  2. 2.Department of Hygiene and EpidemiologyUniversity of Athens Mecial SchoolAthens

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