Archives of Virology

, Volume 140, Issue 12, pp 2243–2254 | Cite as

Spread of Venezuelan equine encephalitis virus in mice olfactory tract

  • A. B. Ryzhikov
  • E. I. Ryabchikova
  • A. N. Sergeev
  • N. V. Tkacheva
Original Papers


Spread of Venezuelan equine encephalitis (VEE) virus and damage of the central nervous system (CNS) in mice infected by respiratory route was studied. Virus concentration in organs and blood, “dose-effect” relationships, and ultrastructural lesions in various tissues were examined in immune and normal mice. We showed, via three independent methods — characteristic curve investigations, tissue virus concentration dynamics, and ultrastructural methods — the spread of VEE virus through the olfactory tract into the brain of immune mice. From these experiments it was concluded that in case of respiratory challenge VEE virus can enter the CNS of normal mice by both vascular and olfactory pathways, while in immune mice the main route is olfactory.


Central Nervous System Infectious Disease Encephalitis Characteristic Curve Normal Mouse 
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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • A. B. Ryzhikov
    • 1
  • E. I. Ryabchikova
    • 1
  • A. N. Sergeev
    • 1
  • N. V. Tkacheva
    • 1
  1. 1.State Research Center of Virology and Biotechnology “Vector”, Kol'tsovoResearch Institute of Molecular BiologyNovosibirsk RegionRussia

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