Archives of Virology

, Volume 140, Issue 12, pp 2123–2133 | Cite as

Host dependent variation of hepatitis C virus: phylogenetic analyses

  • S. Maekawa
  • N. Enomoto
  • M. Kurosaki
  • F. Marumo
  • C. Sato
Original Papers

Summary

Hepatitis C virus quasispecies in six patients from three families were separated by single strand conformation polymorphism analysis and by determination of nucleotide sequences of envelope regions containing the E1 gene segment and hypervariable region-1 of each quasispecies. Four of the six patients had multiple quasispecies. Phylogenetic analyses indicated that all quasispecies from one individual were highly homologous to each other. The homology was higher in the E1 gene segment than in hypervariable region-1. Furthermore, all quasispecies found in members of one family (husband and wife) were also highly homologous, suggesting direct intrafamilial transmission. The direction of hepatitis C virus variation in hypervariable region-1, however, seems to differ depending on the host in intrafamilial transmission.

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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • S. Maekawa
    • 1
  • N. Enomoto
    • 1
  • M. Kurosaki
    • 1
  • F. Marumo
    • 1
  • C. Sato
    • 1
    • 2
  1. 1.Second Department of Internal MedicineTokyo Medical and Dental UniversityTokyoJapan
  2. 2.Division of Health Science, Faculty of MedicineTokyo Medical and Dental UniversityTokyoJapan

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