Archives of Virology

, Volume 140, Issue 11, pp 2011–2026 | Cite as

Coding strategy of the S and M genomic segments of a hantavirus representing a new subtype of the Puumala serotype

  • A. Reip
  • B. Haring
  • C. Sibold
  • R. Stohwasser
  • E. K. F. Bautz
  • G. Darai
  • H. Meisel
  • D. H. Krüger
Original Papers


The hantavirus strain Vranica was previously reported to have been isolated from a bank vole in Bosnia-Hercegovina and associated with the occurrence of hemorrhagic fever with renal syndrome (HRFS) in humans. The complete cDNA nucleotide sequences of the small (S) and medium (M) genomic RNA segments of this virus were determined. Major open reading frames were found in the S and M segment between nucleotide positions 43 and 1341 coding for a polypeptide of 433 amino acid residues and between nucleotide positions 41 and 3 484 coding for 1 148 amino acid residues, respectively. The analysis and the alignment of the nucleotide and the derived amino acid sequences with known sequences of other hantavirus strains demonstrate that Vranica resembles Swedish strains and represents a new virus subtype of the Puumala serotype distinct from the subtypes represented by virus strains CG18–20 and Sotkamo.


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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • A. Reip
    • 1
  • B. Haring
    • 1
  • C. Sibold
    • 1
  • R. Stohwasser
    • 2
  • E. K. F. Bautz
    • 2
  • G. Darai
    • 3
  • H. Meisel
    • 1
  • D. H. Krüger
    • 1
  1. 1.Institut für Medizinische VirologieUniv.-Klinikum Charité der Humboldt UniversitätBerlinFederal Republic of Germany
  2. 2.Institut für Molekulare Genetik der Ruprecht Karls UniversitätHeidelbergFederal Republic of Germany
  3. 3.Institut für Medizinische Virologie der Ruprecht Karls UniversitätHeidelbergFederal Republic of Germany

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