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Archives of Virology

, Volume 116, Issue 1–4, pp 107–118 | Cite as

VP4 relationships between porcine and other rotavirus serotypes

  • H. S. Nagesha
  • I. H. Holmes
Original Papers

Summary

VP4 relationships of Australian porcine rotaviruses were identified using genetic reassortants and MAbs. All porcine virus isolates except BEN-144 appeared to share VP4 antigenicity with OSU virus. VP4 of BEN-144 virus (Gottfried-like virus) showed some antigenic relationships with the human neonatal viruses ST-3 and RV-3. In addition, VP4 of porcine CRW-8 showed antigenic relationships with simian SA-11, RRV and also canine K9 viruses, while that of porcine TFR-41 showed at least one way VP4 antigenic relatedness with UK bovine rotavirus. Furthermore, BMI-1 virus which is antigenically similar to an American virus SB1-A (a naturally occurring reassortant) may have arisen similarly by gene reassortment in nature in Australia.

Keywords

Infectious Disease Virus Isolate Antigenic Relatedness Antigenic Relationship Genetic Reassortants 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Albert MJ, Unicomb LE, Tzipori SR, Bishop RF (1987) Isolation and serotyping of animal rotaviruses and antigenic comparison with human rotaviruses. Arch Virol 93: 123–130Google Scholar
  2. 2.
    Andrew ME, Boyle DB, Coupar BEH, Whitfield PL, Both GW, Bellamy AR (1987) Vaccinia virus recombinants expressing the SA11 rotavirus VP7 glycoprotein gene induce serotype-specific neutralizing antibodies. J Virol 61: 1054–1060Google Scholar
  3. 3.
    Beards GM, Brown DWG (1988) The antigenic diversity of rotaviruses: significance to epidemiology and vaccine strategies. Eur J Epidemiol 4: 1–11Google Scholar
  4. 4.
    Clark HF, Hoshino Y, Bell M, Groff J, Hess G, Bachman P, Offit PA (1987) Rotavirus isolate WI61 representing a presumptive new human serotype. J Clin Microbiol 25: 1757–1762Google Scholar
  5. 5.
    Dyall-Smith ML, Azad AA, Holmes IH (1983) Gene mapping of rotavirus double-stranded RNA segments by Northern blot hybridization: application to segments 7, 8, and 9. J Virol 46: 317–320Google Scholar
  6. 6.
    Estes MK, Cohen J (1989) Rotavirus gene structure and function. Microbiol Rev 53: 410–449Google Scholar
  7. 7.
    Gombold JL, Ramig RF (1986) Analysis of reassortant of genome segments in mice mixedly infected with rotaviruses SA-11 and RRV. J Virol 57: 110–116Google Scholar
  8. 8.
    Gorziglia M, Nishikawa K, Hoshino Y, Taniguchi K (1990) Similarity of the outer capsid protein VP4 of the Gottfried strain of porcine rotavirus to that of asymptomatic human rotavirus strains. J Virol 64: 414–418Google Scholar
  9. 9.
    Greenberg HB, Kalica AR, Wyatt RG, Jones RW, Kapikian AZ, Chanock RM (1981) Rescue of noncultivable human rotaviruses by gene reassortment during mixed infection with ts mutants of a cultivable bovine rotavirus. Proc Natl Acad Sci USA 78: 420–424Google Scholar
  10. 10.
    Holmes IH (1983) Rotaviruses. In: Joklik W (ed) The Reoviridae. Plenum, New York, pp 359–423Google Scholar
  11. 11.
    Hoshino Y, Saif LJ, Sereno MM, Chanock RM, Kapikian AZ (1988) Infection immunity of piglets to either VP3 or VP7 outer capsid protein confers resistance to challenge with a virulent rotavirus bearing the corresponding antigen. J Virol 62: 744–748Google Scholar
  12. 12.
    Hoshino Y, Sereno MM, Midthun K, Flores J, Chanock RM, Kapikian AZ (1987) Analysis by plaque reduction neutralization assay of intertypic rotavirus suggests that gene reassortment occurs in vivo. J Clin Microbiol 25: 290–294Google Scholar
  13. 13.
    Hoshino Y, Sereno MM, Midthun K, Flores J, Kapikian AZ, Chanock RM (1985) Independent segregation of two antigenic specificities (VP3 and VP7) involved in neutralization of rotavirus infectivity. Proc Natl Acad Sci USA 82: 8701–8704Google Scholar
  14. 14.
    Hoshino Y, Wyatt RG, Greenberg HB, Flores J, Kapikian AZ (1984) Serotypic similarity and diversity of rotaviruses of mammalian and avian origin as studied by plaque-reduction neutralization. J Infect Dis 149: 694–702Google Scholar
  15. 15.
    Huang J, Nagesha HS, Dyall-Smith ML, Holmes IH (1989) Comparative sequence analysis of VP7 genes from five Australian porcine rotaviruses. Arch Virol 109: 173–183Google Scholar
  16. 16.
    Johnson MA, Misra RM, Lardelli M, Messina M, Ephraums C, Reeves PR, Bolcevic Z, Noel JS, Hum CP, Mai HV, Dyall-Smith ML, Holmes IH (1989) Synthesis inEscherichia coli of the major glycoprotein of human rotavirus: analysis of the antigenic regions. Gene 84: 73–81Google Scholar
  17. 17.
    Kalica AR, Flores J, Greenberg HB (1983) Identification of the rotaviral gene that codes for hemagglutination and protease-enhanced plaque formation. Virology 125: 194–205Google Scholar
  18. 18.
    Kalica AR, Greenberg HB, Wyatt RG, Flores J, Sereno MM, Kapikian AZ, Chanock RM (1981) Genes of human (strain Wa) and bovine (strain UK) rotavirus that code for neutralization and subgroup antigens. Virology 112: 385–390Google Scholar
  19. 19.
    Mackow ER, Barnet JW, Chan H, Greenberg HB (1989) The rhesus rotavirus outer capsid protein VP4 functions as a haemagglutinin and is antigenically conserved when expressed by a baculovirus recombinant. J Virol 63: 1661–1668Google Scholar
  20. 20.
    Mackow ER, Shaw RD, Matsui SM, Vo PT, Dang M, Greenberg HB (1988) The rhesus rotavirus genes encoding protein VP3: location of amino acids involved in homologous and heterologous rotavirus neutralization and identification of a putative fusion region. Proc Natl Acad Sci USA 85: 645–649Google Scholar
  21. 21.
    Matsuno S, Hasegawa A, Kalica AR, Kono R (1980) Isolation of a recombinant between simian and bovine rotaviruses. J Gen Virol 48: 253–256Google Scholar
  22. 22.
    Midthun K, Greenberg HB, Hoshino Y, Kapikian AZ, Wyatt RG, Chanock RM (1985) Reassortant rotaviruses as potential live vaccine candidates. J Virol 53: 949–954Google Scholar
  23. 23.
    Nagesha HS, Brown LE, Holmes IH (1989) Neutralizing monoclonal antibodies against three serotypes of porcine rotaviruses. J Virol 63: 3445–3549Google Scholar
  24. 24.
    Nagesha HS, Holmes IH (1988) New porcine rotavirus serotype antigenically related to human rotavirus serotype 3. J Clin Microbiol 26: 171–174Google Scholar
  25. 25.
    Nagesha HS, Huang J, Hum CP, Holmes IH (1990) A porcine rotavirus strain with dual VP7 serotype specificity. Virology 175: 319–322Google Scholar
  26. 26.
    Nishikawa K, Fukuhara N, Liprandi F, Green K, Kapikian AZ, Chanock RM, Gorziglia M (1989) VP4 protein of porcine rotavirus strain OSU expressed by a baculovirus recombinant induces neutralizing antibodies. Virology 173: 631–637Google Scholar
  27. 27.
    Offit PA, Blavat G (1986) Identification of two rotavirus genes determining neutralization specificities. J Virol 57: 376–378Google Scholar
  28. 28.
    Offit PA, Clark HF, Blavat G, Greenberg HB (1986) Reassortant rotaviruses containing structural proteins VP3 and VP7 from different parents induce antibodies protective against each parental serotype. J Virol 60: 491–496Google Scholar
  29. 29.
    Ruiz AM, Lopez IV, Lopez S, Espejo RT, Arias CF (1988) Molecular and antigenic analysis of porcine rotavirus YM, a possible new rotavirus serotype. J Virol 62: 4331–4336Google Scholar
  30. 30.
    Shaw RD, Vo PT, Offit PA, Coulson BS, Greenberg HB (1986) Antigenic mapping of the surface proteins of rhesus rotavirus. Virology 155: 434–451Google Scholar
  31. 31.
    Taniguchi K, Morita Y, Urasawa T, Urasawa S (1987) Cross-reactive neutralization epitopes on VP3 of human rotavirus: analysis with monoclonal antibodies and antigenic variants. J Virol 61: 1726–1730Google Scholar
  32. 32.
    Ward RL, Knowlton DR, Schiff GM, Hoshino Y, Greenberg HB (1988) Relative concentrations of serum neutralizing antibody to vp3 and vp7 proteins in adults infected with a human rotavirus. J Virol 62: 1543–1549Google Scholar

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • H. S. Nagesha
    • 1
  • I. H. Holmes
    • 1
  1. 1.School of MicrobiologyUniversity of MelbourneParkvilleAustralia

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