Archives of Virology

, Volume 61, Issue 3, pp 245–250 | Cite as

The effect of pyrophosphate analogues on influenza virus RNA polymerase and influenza virus multiplication

  • S. Stridh
  • E. Helgstrand
  • B. Lannerö
  • A. Misiorny
  • G. Stening
  • B. Öberg
Brief Report
Received:
Accepted:

Summary

Analogues of pyrophosphate have been tested as inhibitors of influenza virus RNA polymerase activity in cell-free assays. The most active compound, phosphonoformic acid (PFA), reduced the polymerase activity to 50 per cent at a concentration of 20 µm. The inhibition was dependent on the type of divalent cation present in the assay. PFA at a concentration of 400 µm also inhibited the influenza virus plaque formation by 90 per cent.

Keywords

Infectious Disease Influenza Influenza Virus Active Compound Pyrophosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • S. Stridh
    • 1
  • E. Helgstrand
    • 1
  • B. Lannerö
    • 1
  • A. Misiorny
    • 1
  • G. Stening
    • 1
  • B. Öberg
    • 1
  1. 1.Research and Development LaboratoriesAstra Läkemedel ABSödertäljeSweden

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