Archives of Virology

, Volume 107, Issue 3–4, pp 307–313 | Cite as

Langerhans cells in vaccinia virus infection in mouse skin

  • Y. Becker
  • E. Sprecher
Brief Report
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Accepted:

Summary

Langerhans cells function as potent antigen-presenting cells in the epidermis. They were shown to play an essential role in the mechanisms of defense of the skin against viral infections. In the present study, the response of Langerhans cells to infection of the skin with vaccinia virus was investigated. Decrease in Langerhans cell density in the skin was accompanied by an increase in the pathogenicity of the WR and Noguchi but not of the Lister strain of vaccinia virus. Langerhans cell density was shown to increase rapidly at the site of inoculation with the two pathogenic strains of vaccinia virus.

Keywords

Infectious Disease Viral Infection Cell Density Essential Role Vaccinia Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Y. Becker
    • 1
  • E. Sprecher
    • 1
  1. 1.Department of Molecular Virology, Faculty of MedicineHebrew UniversityJerusalemIsrael

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