Advertisement

Archives of Virology

, Volume 59, Issue 3, pp 269–274 | Cite as

Antiviral activity of virus-like particles fromLentinus edodes (Shiitake)

  • M. Takehara
  • K. Kuida
  • K. Mori
Brief Report

Summary

Interferon (IF) induction and antiviral activity by purified spherical (S) or filamentous (F) virus-like particles and S-derived RNA was studied. A single administration of S particles prior to virus challenge reduced significantly the mortality of mice infected with western equine encephalitis (WEE) virus.

Keywords

Infectious Disease Interferon Encephalitis Antiviral Activity Single Administration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Banks, G. T., Buck, K. W., Chain, E. B., Himmelweit, F., Marks, J. E., Tyler, J. M., Hollings, M., Last, F. T., Stone, O. M.: Viruses in fungi and interferon stimulation. Nature218, 542–545 (1968).Google Scholar
  2. 2.
    Dieleman-van-Zaayen, A.: Virus-like particles in a weed mould growing on mushroom trays. Nature216, 595–596 (1967).Google Scholar
  3. 3.
    Hollings, M.: Virus associated with a die-back disease of cultivated mushroom. Nature196, 962–965 (1962).Google Scholar
  4. 4.
    Inoue, T.: Virus-like particles fromL. edodes. Mushroom2, 18–22 (1970).Google Scholar
  5. 5.
    Ishida, N.: A mushroom extract as an interferon inducer. In:Nagano, Y., Levy, H. B. (eds.), Interferon, 156–164. Tokyo: Igaku Shoin 1970.Google Scholar
  6. 6.
    Kleinschmidt, W. J., Ellis, L. F., van Frank, R. M., Murphy, E. B.: Interferon stimulation by a double-stranded RNA of a mycophage in statolon preparations. Nature220, 167–168 (1968).Google Scholar
  7. 7.
    Lampson, G. P., Tytell, A. A., Field, A. K., Nemes, M. M., Hillemann, M. R.: Inducers of interferon and host resistance. I. Double-stranded RNA from extracts ofPenicillium funiculosum. Proc. Nat. Acad. Sci. U.S.A.58, 782–789 (1967).Google Scholar
  8. 8.
    Lemke, P. A., Nash, C. H.: Fungal viruses. Bacteriol. Rev.38, 29–56 (1974).Google Scholar
  9. 9.
    Lowry, O. H., Rosebrough, N. J., Farr, A. L., Randall, R. J.: Protein mesurement with the Folin phenol reagent. J. biol. Chem.193, 265–275 (1951).Google Scholar
  10. 10.
    Merigan, T. C.: Non-viral substance which induce interferon. In: Finter, N. B. (ed.), Interferons and Interferon Inducers, 45–72. Amsterdam-London: North-Holland Publish. Co. 1973.Google Scholar
  11. 11.
    Mori, K., Mori, K.: Studies on virus-like particles inLentinus edodes (Shii-ta-ke). Mushroom Sci.IX (Part I), 541–556 (1974).Google Scholar
  12. 12.
    Takehara, M., Suzuki, N.: Interferon induction by rice dwarf virus RNA. Antiviral activityin vitro and its stability. Arch. ges. Virusforsch.40, 291–299 (1973).Google Scholar
  13. 13.
    Takehara, M.: Interferon inducing capacity and antiviral action of double-stranded RNA from rice dwarf virusin vitro. Kobe J. med. Sci.21, 33–41 (1975).Google Scholar
  14. 14.
    Takehara, M.: Antiviral effects of double-stranded RNA from rice dwarf virus on infection of mice with western equine encephalitis virus. Microbiol. Immunol.21, 309–315 (1977).Google Scholar
  15. 15.
    Tsunoda, A., Ishida, N.: A mushroom extract as an interferon inducer. Ann. N.Y. Acad. Sci.173, 719–726 (1970).Google Scholar
  16. 16.
    Ushiyama, R., Nakai, Y., Ikegami, M.: Evidence for double-stranded RNA from polyhedral virus-like particles inLentinus edodes (Berk.) Sing. Virology77, 880–883 (1977).Google Scholar
  17. 17.
    Yamashita, S.: Fungal viruses. Chemistry and Biology12, 2–14 (1974). (In Japanese.)Google Scholar

Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • M. Takehara
    • 1
  • K. Kuida
    • 2
  • K. Mori
    • 2
  1. 1.Department of MicrobiologyKobe University School of MedicineKobeJapan
  2. 2.Mushroom Research Institute in JapanKiryuJapan

Personalised recommendations