Archives of Virology

, Volume 119, Issue 1–2, pp 37–42 | Cite as

Replication of avian influenza viruses in humans

  • A. S. Beare
  • R. G. Webster
Original Papers


Volunteers inoculated with avian influenza viruses belonging to subtypes currently circulating in humans (H1N1 and H3N2) were largely refractory to infection. However 11 out of 40 volunteers inoculated with the avian subtypes, H4N8, H6N1, and H10N7, shed virus and had mild clinical symptoms: they did not produce a detectable antibody response. This was presumably because virus multiplication was limited and insufficient to stimulate a detectable primary immune response. Avian influenza viruses comprise hemagglutinin (HA) subtypes 1–14 and it is possible that HA genes not so far seen in humans could enter the human influenza virus gene pool through reassortment between avian and circulating human viruses.


Immune Response Influenza Clinical Symptom Influenza Virus Antibody Response 
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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • A. S. Beare
    • 1
  • R. G. Webster
    • 2
  1. 1.Clinical Research CentreHarvard HospitalSalisburyU.K.
  2. 2.Department of Virology and Molecular BiologySt. Jude Children's Research HospitalMemphisUSA

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