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Archives of Virology

, Volume 85, Issue 3–4, pp 305–311 | Cite as

Recent H1N1 viruses (A/USSR/90/77, A/Fiji/15899/83, A/Firenze/13/83) replicate poorly in ferret bronchial epithelium

  • C. Sweet
  • R. A. Bird
  • D. M. Coates
  • H. A. Overton
  • H. Smith
Brief Report

Summary

Three recent wild-type H1N1 influenza virus isolates (A/USSR/90/77, A/Fiji/15899/83 and A/Firenze/13/83) replicated poorly in organ cultures of ferret bronchial tissue compared with the replication of an H3N2 wild-type virus (A/England/939/69). All four viruses replicated well in nasal turbinate tissue. Examination of one H1N1 virus (A/USSR/90/77)in vivo showed heavy infection in the upper respiratory tract of ferrets but little in the lower respiratory tract. These results raise the possibility that the mildness of human influenza arising from the H1N1 strains may be due to lack of capacity to attack the lower respiratory tract as well as the presence of antibody in previously exposed persons.

Keywords

Influenza Influenza Virus Lower Respiratory Tract H1N1 Virus H1N1 Influenza 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • C. Sweet
    • 1
  • R. A. Bird
    • 1
  • D. M. Coates
    • 1
  • H. A. Overton
    • 1
  • H. Smith
    • 1
  1. 1.Department of MicrobiologyUniversity of BirminghamBirminghamUnited Kingdom

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