The genetic aspects of influenza virus filamentous particle formation
- 68 Downloads
We analysed the genetic content of reassortants between parent viruses differing in their ability to form filaments. The results suggest that primarily HA, M, and NP genes are involved in the control of the filament forming ability. A lower buoyant density of the filamentous forms as compared to spherical particles allowed us to obtain a sufficiently pure population of filaments. A difference in the UV-inactivation kinetics between filaments and spherical virions suggests that the infectious filamentous forms are probably represented by multigenomic particles or partial heterozygotes.
Unable to display preview. Download preview PDF.
- 1.Choppin PW, Compans RW (1975) The structure of influenza virus. In: Kilbourne ED (ed) The influenza viruses and influenza. Academic Press, New York, pp 15–51Google Scholar
- 2.Kaverin NV, Rudneva IA, Smirnov YA, Finskaya NN (1988) Human-avian influenza virus reassortants: effect of reassortment pattern on multi-cycle reproduction in MDCK cells. Arch Virol 103:117–126Google Scholar
- 3.Ruigrok RWH, Krijgamen PC, de Roude-Verlop FM, de Jong JC (1985) Natural heterogenicity of shape, infectivity and protein composition in an influenza A (H3N2) virus preparation. Virus Res 3:69–76Google Scholar